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Biomedical subjects

M Gafà

Publications and source records attributed to M Gafà.

At least 37 records · Page 2Linked to original sources
PubMed1983

Lipase clearance in experimental acute pancreatitis.

Renal clearance of lipase, expressed as a proportion of simultaneous creatinine clearances was evaluated in an experimental model of acute pancreatitis in the rat. The lipase creatinine clearance ratio resulted very low in normal and control animals, while in rats with acute pancreatitis it increased regularly, significantly and proportionally to the degree of pancreatic damage. These observations indicated that, in this experimental model, the increased lipase creatinine clearance ratio is a sensitive index of acute pancreatitis, providing a basis for using the test in clinical practice.

Acute Disease↗
PubMed1981

[Diagnostic problems in lymphomas of the gastrointestinal tract].

The experience of the Authors refers to 10 cases of gastrointestinal lymphomas which came to our observation for December 1975 to July 1980. Of the 10 cases observed, 7 had a primary representation of the disease, the other 3 showed a generalized ò lymphoma. In 6 patients the stomach was affected and the small intestines in 4. Total or subtotal gastrectomy was carried out in 6 patients, Ileal resections in 3 and right hemicolectomy in 1. There were no post-operative mortalities and after treatment 7 patients survived. The Authors emphasize the difficulty created by the lymphomas of the digestive tract, particularly the primary ones, in as far as an exact preoperative diagnosis is concerned.

Adolescent↗
PubMed1981

[Our experience in the treatment of nonneoplastic obstructive pathology of the common bile duct by papillosphincteroplasty (author's transl)].

Starting from a discussion of the controversial views on the indications and correct execution of papillosphincteroplasty (PSP), the Authors report their own experience with the procedure and their first-hand evaluation of its merits, based on a series of 77 patients treated by PSP over the last 3 years (out of a total of 650 patients treated surgically for nonneoplastic pathology of the biliary tract). Their followup to date (up to 3 years after surgery), based on clinical, biohumoral and radiological findings, shows that the long-term results were excellent in 85%, good in 13%, and poor in 2% of the cases.

Adult↗
PubMed1980

[Cimetidine after operations on Vater papilla (author's transl)].

The effectiveness of Cimetidine in preventing complications, like acute pancreatitis and hemorrhagic gastritis, after operations on Vater papilla (ISP) is studied. In patients treated with Cimetidine the volume of nasogastric secretion was smaller and diastasemia and diastasuria treated values returned to the normal range earlier than in non-treated patients. In the latter group a case of pancreatitis and one of post-operative hemorrhagic gastritis were found. The treated patients, instead, did not suffer these complications. It was concluded that Cimetidine after IPS is useful, because it complies with the request that determined its employ.

Adult↗
PubMed1978

[Experimental study on hepatic encephalopathy: EEG and blood amino acid findings].

The AA. describe a method of gradual occlusion of the portal vein in the rat to induce a hepatic encephalopaty. This method allows to realise a condition of hepatic ischemia and a portal hypertensive state accompanied by spontaneous portal-systemic shunts. These two factors produce a hepatic encephalopaty like in cirrhotic state or in patients after portal systemic anastomosis. A part from similar behavior at the beginning of the encephalopaty it is possible to define two classes of animals: one showing a slow recovery and one showing a transient and slight improvement followed at the end by the death of the animal. The AA. found a definite correlation amoung the clinica, EEG's, serum aminoacids and biochemical data. Probably the different anatomical and phisiological aspects of the induced portal systemic shunts and the different ways of hepatic rivascularization may determine the two different evolutions of the animals.

Amino Acids↗
PubMed1978

[Surgical aspects of thrombosis in the portal system (author's transl)].

The Authors present and discuss clinical and therapeutic aspects of several cases of chronic portal thrombosis, troncular and radicular, either isolated or variously associated. Splenoportography and selective arteriography do not always provide a clear-cut picture of the vascular situation, particularly in the presence of mural thrombi. Surgery may be needed as an emergency measure in cases of hemorrhage, but the best results are obtained if it can be done electively. Indications, however, must be evaluated very carefully in each individual case, especially for thrombosis not associated with cirrhosis of the liver, in which the tendency to a more favorable natural evolution may invite a more conservative approach. The choice of surgical procedures is dictated essentially by the site of obstruction in the portal system. After discussing the indications for various methods, the authors present some cases of thrombosis involving only the superior mesenteric vein, managed successfully by disobliteration and mesenterocaval anastomosis.

Adolescent↗
PubMed1977

[Valvular insufficiency after venous thrombosis. Experimental study].

Venous thrombosis can produce lesions of valvular cusps which are generally ascribe to the phase of thrombus organization. Valvular lesions hold a very important role in the genesis of the post phlebitic chronic venous insufficiency. Experimental thrombosis had been induced in dogs with electrical stimulation of femoral veins to study morphological aspects of valvular cusps in various evolutive phases of thrombosis. Results emphasize too early onset and quick evolution of valvular damage. It can contribute to explain frequent failures of attempted therapy about prevention of post phlebitic syndromes.

Animals↗
PubMedDate not supplied

[Postoperative gastrointestinal hemorrhages after pulmonary resections (author's transly].

Postoperative gastrointestinal hemorrhages are a infrequent complication of pulmonary resections. Nevertheless they are threatening seriously patient's life because a critical illness as gastrointestinal hemorrhage in such casses hit patients whose vital functions are compromised from recent thoracic surgery. The pathogenetic questions, as well critical problems of diagnosis and treatment, are discussed on the basis of three observed cases.

Gastrointestinal Hemorrhage↗
PubMedDate not supplied

[Pelvic recurrences after curative surgery for rectal cancer].

This report updates an experience with local recurrences of rectal cancer after curative surgery. Overall 13 year period (1976-1988) 254 patients were operated on in the II Surgical Clinic of Parma University for rectal cancer. Only 122 patients who underwent potentially curative resection were examined. Approximate recurrence rates according to patients age, site, type and stage of primitive tumour, tumour complications and surgical procedures were evaluated. The overall local failure rate was 17.2% with 12 patients having local failure alone and 9 patients having concurrent local failure and distant metastasis. Local failure occurred predominantly in tumour bed, involving the anastomosis in 2 cases. Relapse developed primarily at colo-rectal anastomosis in only 1 patients, 20% of recurrences were diagnosed within the first postoperative year; 65% within the second and 90% within the third. Stage of primary tumour was the most predictive factor for eventual relapse. Minute foci of tumour not encompassed by the first operation led to local recurrences in most of the cases, but relapses were independent of operative procedures adopted. The authors conclude that surgery, even if correctly performed, is not sufficient to prevent the risk of local recurrence of rectal cancer. They believe that routine adjuvant radiation therapy after surgical treatment of rectal cancer should improve survival rate.

Age Factors↗
PubMedDate not supplied

[Locoregional recurrences following curative surgery for colon cancer].

This study explores the patterns of local recurrence after curative operations for colonic cancer. Over a 13 year period (1976-1988) 486 patients were operated on in the Surgical Clinic of Parma University for colonic cancer, but only 296 patients who underwent potentially curative resection were examined. The influence of patients' age, disease stage, site and grade, presence of obstruction or perforation and type of surgical procedures were examined as prognostic factors for local cancer recurrence. A total of 28 patients (14%) relapsed after surgery and 19 were found to have simultaneous distant metastasis. 86% of recurrences were evident within the first 2 years. Local recurrence rate increased with more advanced Duke's stage and stage of the primary tumour was most predictive for eventual relapse. The recurrences occurred within the operative resection site involving the anastomosis by inward growth at the suture line. Minute foci of adenocarcinoma not encompassed by the first operation might lead to local recurrences; the authors do not rule out, however, the rare possibility of the implantation of exfoliated malignant cells. Despite the attempt to carry out an intensive followup in terms of early diagnosis of recurrence in colonic surgery, the presence of local recurrences is associated with extremely poor prognosis independent of operative procedure performed. The authors believe that routine adjuvant radiation therapy after surgical treatment of locally advanced colonic cancer could improve survival rate.

Age Factors↗
PubMedDate not supplied

[Cancer of the colon and cholelithiasis: bile bacteria, composition of the stones and the bile].

Our recent studies have shown a significant association between lithiasic biliary disease and colorectal cancer. This could be due to the existence of risk factors common to both disease or to a cause-effect correlation between them. This latter hypothesis is supported by the observation in gallstone patients of the increase of biliary and fecal concentrations in secondary biliary acids. These could have co-carcinogenic effect on the colon. With a view to singling out further elements which might help us to understand more clearly the possible cause-effect correlation between cholelithiasis and colon cancer, we examined 12 patients affected by both diseases. In these, we evaluated the composition of the gallbladder stones, by means of spectrophotometry and diffractometry. Bile samples were taken from the gallbladder and used to examine the lipidic composition and the cholesterol saturation index according to Carey. In addition bacteriological examinations were carried out. The results were compared with those of 10 patients with cholelithiasis but not cancer, 10 with cancer but not cholelithiasis and 10 with neither. Analysis of the results did not reveal significant differences in gallstone and bile composition between colon cancer patients with concomitant gallstones and control groups. However, in cancer patients with gallstones a higher incidence of bile bacteria (35.7%) was observed than in the other groups. Bile bacteria were observed more frequently in right colon cancer patients who had pigment stones in 75% of the cases. The results seem to evidence peculiarities in patients with a cancer of right colon.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗