Biomedical subjects

M Ganten

Publications and source records attributed to M Ganten.

3 recordsLinked to original sources

PubMed2003

[Follow up of Crohn's disease under therapy with hydro-MRI].

PURPOSE: Evaluation of typical MRI-findings in patients with Crohn's disease receiving therapy. Correlation with the course of disease. PATIENTS AND METHODS: 81 follow-up MRI-studies in 25 patients conducted within a period of 3 weeks to 4 years were evaluated retrospectively. Therapy consisted in various combinations of antibiotics and immunosuppressive agents and if necessary operation. The findings of the MRI-studies were correlated with clinical data (e.g.operation of Crohn's complications) and the subjective perception during therapy. RESULTS: The morphological substrate of Crohn's disease in the Hydro-MRI images is reliably detected. Especially in a delineation of extraluminal changes MRI is superior to endoscopy and enteroclysis. Independent from clinical symptoms short- and mid-term follow-up showed inflammatory changes of the intestinal wall in all 25 patients. In 24/81 studies there was persistence or even progression of Crohn's disease in the MRI-studies, although patients were free of symptoms by the time of image acquisition. CONCLUSION: Hydro-MRI is a modality for the evaluation of inflammatory changes in patients with Crohn's disease. Independent from clinical symptoms persistence of Crohn's disease is detectable.

Adolescent↗

PubMed2002

Aortic elasticity measurement using ECG-gated multi-slice computed tomography.

Vessel elasticity is a functional parameter of the vessel wall which is correlated with cardiovascular disease. Non-invasive measurement of elasticity is difficult. The aim of this project was to develop a method to measure aortic elasticity using multi-slice computed tomography (CT). The method is based on the reconstruction of time-resolved images of the aortic cross-section from CT raw data and ECG data. It can be integrated into a standard CT angiography examination without the need for additional radiation dose. The method was validated using a phantom set-up with porcine aortic specimens. Results show a good agreement between an optical reference and the CT measurement. Patient examinations show that changes in aortic wall distension can be measured and that these changes are reduced in patients with atherosclerosis.

Animals↗

PubMedDate not supplied

[Tenoplasty of the long head of the biceps in massive rotator cuff tear].

AIM: It was the aim of this study to investigate the success of biceps tenoplasty in massive interval rotator cuff tears. METHOD: Fifteen patients, who had a massive rotator cuff tear in the area of the interval and a pathology of the long head of the biceps tendon, were examined clinically and by MRI. A primary reconstruction of the rotator cuff tear was possible in none of the patients. All patients had a secondary reconstruction with a biceps tenoplasty. The Constant Score was determined postoperatively and the satisfaction of the patients was explored. RESULTS: The mean age at the time of the operation was 55 years. The examination was 23 months postoperatively. A simultaneous rupture of the supraspinatus- and subscapularis tendon was seen in 12 patients, an additional rupture of the infraspinatus tendon in 3 patients intraoperatively. The long head of the biceps was dislocated in 10 patients and subluxated in 5 patients. The postoperative determined Constant Score was 82.7 points. The personal satisfaction was investigated by asking for the German schoolmarks, which extend from 1 (excellent) to 6 (not satisfactory). The preoperative schoolmark was 5.2 and the postoperative schoolmark 1.4. In the MRI examination one rerupture could be seen, an atrophy of the supraspinatus tendon was evaluated in four patients. Knowing the postoperative result, all patients would have repeated the operation. CONCLUSION: The biceps tenoplasty is a suitable operative method to achieve a better function and relief of pain in massive interval rotator cuff tears with simultaneous pathology of the long head of the biceps tendon. A high degree of personal satisfaction for the patient can be achieved.

Adult↗