DNA-dependent DNA and RNA polymerases and tRNA-methyl-transferases in human leukemia and differentiating Friend virus leukemia cells.
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Animals↗
Biomedical subjects
M Garbrecht
Publications and source records attributed to M Garbrecht.
[Ophthalmological diagnosis of cytomegalic retinitis (author's transl)].
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Anemia, Pernicious↗
[Determination of the DNA-dependent RNA polymerase from human leukocytes in a simple cell-free system (author's transl)].
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Animals↗
[Transfer RNA methyltransferases in different hemoblastoses].
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Humans↗
[DNA directed nucleic acid polymerases in normal and pathologic human leukocytes: differentiation, characterization and purification of DNA polymerases I, II and RNA polymerases A, B and their in vitro influence by cytostatics].
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Animals↗
[DNA directed nucleic acid polymerases in normal and pathologic human leukocytes: increased specific activities and different kinetics of RNA polymerase B in cell nuclei of pathological cells].
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DNA-Directed RNA Polymerases↗
[The pharmacokinetics of doxorubicin].
Doxorubicin serum levels were measured with a highly specific reversed-phase HPLC-method in patients undergoing combination chemotherapy. Serum elimination kinetics of doxorubicin follow a bi- or triphasic first order pattern with a high interpatient variability. T 1/2 of the first distribution phase was 5.4 min. T 1/2 of the terminal steady-state elimination phase was 1273 min. After consecutive bolus application of 15 mg/m2 (4 times per 48 h) cumulation of doxorubicin was found in patient's serum. Serum levels 4 h after bolus injection of doxorubicin were found to be correlated with the area under the elimination curve. Therefore, 4 h serum levels after bolus injection can be used for clinical studies correlating pharmacokinetics with antineoplastic properties of doxorubicin.
Adolescent↗