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Biomedical subjects

M García Clemente

Publications and source records attributed to M García Clemente.

5 recordsLinked to original sources
PubMed2004

[Metastatic pulmonary angiosarcoma].

Angiosarcoma involving the lung, usually a result of metastatic disease, is a rare disorder. Primary angiosarcoma of the lung is an extremely rare tumor. The lung is one of the most common sites of metastatic involvement, along with liver and lymph nodes. Hemoptysis is the most frequent presenting symptom even with diffuse pulmonary hemorrhage. Chest radiography may reveal a spectrum of findings ranging form normal to bilateral nodular lesions. Early diagnosis is not common because of the rarity of angiosarcoma in the lung and hence, low index of suspicion. The prognosis is generally poor, with a median survival of 9 months after diagnosis.

Atrial Fibrillation↗
PubMed1993

[Tuberculosis and HIV infection. Evaluation of 132 cases].

Tuberculosis is currently one the more frequent opportunistic infections in patients infected by Human Immunodeficiency Virus (HIV) in our setting. Its extrapulmonary localization is considered as diagnostic of the Acquired Immunodeficiency Syndrome (AIDS). We have evaluated the epidemiological, clinical, microbiological, histological and immunological characteristics of 120 patients in the Asturias region who had a tuberculosis diagnosed in any localization, during the period between 1984 and 1991, belonging to a series of 570 patients infected by HIV. Pulmonary types were comparatively analyzed to the extrapulmonary and disseminated ones. Tuberculosis was pulmonary only in 44 occasions (PT), in 36 it was extrapulmonary (EPT) and in 52 disseminated (DT). The more frequent risk factor for the HIV infection was the parenteral consumption of drugs (78.8%). The final diagnosis was microbiologic in 81% of the cases, while bacilloscopia was positive in 62% of the cases. The histologic study showed the presence of granulomas in 86% of the tissues studied and necrosis in 81%. EPT and DT were related with a worse immune situation, bigger mortality rates attributed to tuberculosis and worse survival (p 0.069). Tuberculosis in patients infected by HIV appears mainly in CDVP, being its symptoms the normal ones; but extrapulmonary forms are clearly predominant and within this group those with a ganglionar localization. Normal diagnostic procedures yield a good result. EPT and DT are significantly related to a more severe immunodeficiency in comparison with PT. Survival and prognosis are better in the PT group.

Actuarial Analysis↗
PubMed1990

Cytologic and bacteriologic analysis of fluid and pleural biopsy specimens with Cope's needle. Study of 414 patients.

This article describes the results of a dual diagnostic procedure, thoracentesis and pleural biopsy with a Cope's needle, in 414 patients with pleural effusion of unknown origin. A diagnosis of neoplasia or pleural tuberculosis was obtained in 241 subjects (149 with neoplasias and 92 with pleural tuberculosis). In an additional 55 patients, a diagnosis of tuberculosis or neoplasia was obtained using other procedures (15 with tuberculosis and 40 with neoplasias). In 105 subjects, the effusion was neither tuberculosis nor neoplasia. Thirteen patients were excluded from this study due to the impossibility of follow-up. The diagnostic process was repeated in 64 patients. Complications occurred in 46 patients (11%), of which 42 were pneumothorax. The dual diagnostic sensitivity in our series of thoracenteses and pleural biopsies made with a Cope's needle was 86% in tuberculosis and 79% in neoplasia with 100% specificity. The probability of a case being neither tuberculosis nor pleural neoplasia (negative predictive value) when the liquid and the pleural biopsy specimen are nonspecific (each procedure having been applied only once on each patient) is 56%, although a negative result does not exclude these diagnoses. In our opinion, the repetition of the dual procedure is indicated considering the scant morbidity and zero mortality.

Adolescent↗
PubMed1989

[Characteristics of the incidence of bronchogenic carcinoma in extreme age groups].

The protocols of 852 patients with bronchogenic carcinoma (BC) were reviewed in order to establish its characteristics in the most extreme age groups in which it appears: group I, patients aged 40 years or younger (18 cases), and group II, patients aged 80 or older (19 cases). No differences were found in the relation men/women, time elapsed from the beginning of symptoms to diagnosis, staging and survival. The differentiating characters included the greater incidence of thoracic pain, microcytic carcinoma, surgery possibilities and therapeutic attitude in group I, and the predominance of squamous cell carcinoma in group II. The continuous and intense exposure to tobacco smoke is common to both groups.

Adult↗