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M García Fuentes

Publications and source records attributed to M García Fuentes.

11 recordsLinked to original sources
PubMed1992

Interleukin-2 deficit in hemodialysis patients. Role of prostaglandins.

Uremic patients suffer from various immunological alterations, whose pathogenesis is still unknown. Here, we studied 37 hemodialysis patients in order to investigate the role of prostaglandins (PGs) in uremic immunological deficiency, specifically in relation to interleukin-2 (IL-2) synthesis. We confirmed previous published data on deficient response to PHA in chronic renal failure patients (cpm, mean +/- SEM: 15,400 +/- 2,100 in uremics vs. 29,500 +/- 3,380 in controls, p < 0.04) and established a correlation between this deficiency and diminished IL-2 synthesis (r = 0.619, p < 0.05). The direct measurement of PGs in lymphocyte cultures showed greatly increased concentrations in the presence of uremic serum (US). We found that PGs synthesis can be inhibited by up to 80% if cultures are supplemented with indomethacin (IND--a cyclooxigenase inhibitor) or by removal of monocytes (producers of PGs). Both methods situated the uremic proliferative response within the normal range in cultures with FCS, and close to the normal range in cultures with US. We observed a deficit of IL-2 in hemodialysis patients (means +/- SD: 8,940 +/- 6,420 in uremics vs. 16,900 +/- 3,890 in controls). Addition of exogenous IL-2 normalized lymphocyte response even in US cultures, with no additive effect between PGs inhibition and exogenous IL-2 except in US cultures. It is suggested that IL-2 deficit of uremics depends, at least in part, on an increase in PGs synthesis induced by US.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

[Pneumococcal meningitis in the infantile population of Cantabria].

A retrospective study of pneumococcal meningitis was carried out. This study included 22 cases of this illness that occurred in 17 pediatric patients in Cantabria between 1977 and 1990, inclusive. Three children suffered from recurrent meningitis. The age range of the patients was 0.3-14 years, with a mean age of 4 years. Of these cases, 77.4% occurred in the winter or spring. In 14 cases of meningitis (63.6%), corresponding to 9 patients, underlying pathology was observed: cranial fracture, occipital dermoid cyst, splenectomy, congenital cardiopathy, epilepsy and gastroduodenal "situs inversus". The isolated pneumococci were found to be resistant to penicillin and chloramphenicol in 4 cases. One patient suffered from septic shock. The outcome was complete recovery in 19 cases (86.4%), recovery with sequelae (deafness and epilepsy, respectively) in 2 cases (9.1%) and death in another 2 cases. CSF protein levels elevated above 150 mg/dl and the absence of glucose in the CSF were found to be the most useful analytical indicators of the seriousness of the illness.

Adolescent↗
PubMed1991

[Nephrotic syndrome in infancy: clinical, therapeutic and follow up characteristics in 100 cases].

In order to understand the natural history, clinical features, anatomopathological findings and response to the initial treatment with steroids of the nephrotic syndrome (NS) during childhood, a group of 100 children under 14 years (46 with renal biopsy) observed for an average period of 4 years and 8 months, was reviewed retrospectively. The patients were divided into 3 groups: idopathic NC (89), secondary NS (9) and NS in the first six months of life (2). In the group of idiopathic NS, in which the significant predominance of males (2.8/1) was confirmed, in 69% of the patients the diagnosis was made between the ages of 2 and 5 years. Edemas were found, sometimes accompanied by oliguria and weigh gain, in 77% of the cases. The periods of hypertension and hematuria were infrequent and brief. Thirty eight kidney biopsies were carried out and showed: 25 minimal changes NS, 7 diffuse mesangial proliferative glomerulonephritis (DMPGN), 3 membranoproliferative glomerulonephritis (MPGN), 2 membranous glomerulonephritis (MGN) and 1 segmental and focal glomerulosclerosis. Of the 83 patients treated in first instance with corticosteroids, a positive response was obtained in 72 (87%), although 44% of them have shown to be cortico-dependent. After an average follow up period of 4 years and 8 months, only 2 children, one with MPGN and the other with MGN, are now in chronic renal failure (CRF). In 5 ot the 9 patients included in the second group, the NS was secondary to a Henoch Schönlein purpura. The kidney biopsies showed DMPGN in three of them.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Cortex Hormones↗
PubMed1989

[Morbidity caused by accidents in the child population in Cantabria].

This work presents the morbidity by accident which required medical assistance, covering the population from zero-to-nineteen years of the Autonomic Community of Cantabria between the first of October 1986 and the 30th of September 1987. For this study 1610 families chosen at random depending on the zone's population, were interviewed. The number of registered accidents was of 527 and the number of injured children of 453, which represents the 28.14% of the total of children interviewed. A 42.66% required out-patient medical assistance, a 53.82% required medical assistance at the hospital's emergency units and a 3.5% had to enter hospital. A 5.1% of the accidents were considered very serious, no deaths occurred. The circumstances that defined the accidents were analyzed and the facts that conditioned them, subject, agent and mean.

Accidents↗
PubMed1988

[Polyuria].

Explore the source record for details and available documents.

Child↗
PubMed1988

[Idiopathic form of late hemorrhagic disease caused by a deficiency of vitamin K. A presentation of 3 cases].

Three one month old infants with idiopathic late haemorrhagic disease due to vitamin K deficiency are reported. Patients had been exclusively breast fed and had not received vitamin K at birth. Initial symptomatology was typical in the three cases. Two of them had an intracranial haemorrhage with exitus in one of them. Coagulation study showed non measurable levels of PT and PTT and a significant reduction in vitamin K dependent factors. Coagulopathy was corrected with parenteral administration of vitamin K and fresh plasma. Pathogenic factors of this entity are reviewed and present day recommendations to prevent occurrence of this problem are discussed.

Female↗