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M García González

Publications and source records attributed to M García González.

17 recordsLinked to original sources
PubMed2005

[Nosocomial infection by multiresistant pathogens during one year in a secondary hospital: clinical an epidemiological analysis].

BACKGROUND: Currently growing medical and social significance of nosocomial infection by multiresistant pathogens (NIMP) prompted us to establish its incidence, nosology, presenting forms in admission areas, and mortality in a secondary hospital, Lleida (Spain). METHOD: For that purpose, we analyzed the first year experience of a unit for the control of nosocomial infection (NI) created in our hospital. From January to December 2000, 79 patients with a NIMP admitted to the University Hospital Arnau de Vilanova entered in this prospective, descriptive study. RESULTS: The overall annual incidence of NIMP was 4.0 per 103 patients admitted. Acinetobacter baumannii showed the highest individual rate of incidence, particularly, at the Intensive Care Unit (15.4 per 103 patients admitted; p < 0.001). By nosologies, infection prevailed over colonization (69.6% vs 30.4%; p < 0.001). Mean hospital stay length increased in colonized patients (38.9 days). Finally, overall mortality was high (29.1%); again, A. baumannii was the agent most frequently detected in death cases (66.6%; p < 0.001). CONCLUSIONS: Surveillance and control measures are required for the prevention of NIMP. Incidence studies how this, can be useful to create a database to establish the distribution and occurrence of NI, including the detection of multiresistant pathogen outbreaks.

Adolescent↗
PubMed2002

Prevention of de novo hepatitis B infection in liver allograft recipients with previous hepatitis B infection or hepatitis B vaccination.

OBJECTIVES: To assess de novo hepatitis B virus (HBV) transmission from liver donors with HBV serum markers (HBM) to their recipients and the need for HBV vaccination before liver transplantation. METHODS: A total of 108 orthotopic liver transplantations for nonviral disease and the risk of developing de novo hepatitis B based on HBMs before transplantation have been studied. Of the 108 patients, 94 met the study criteria and were divided into two groups: 27 who had HBMs before transplantation (from past infection or by previous vaccination) and 67 who had no HBM. Development of de novo hepatitis B was determined by analytical, serological, and histological parameters. RESULTS: No case (0%) of de novo hepatitis B was detected in the pretransplantation HBM group, whereas there were 10 cases (14.5%) in the other group (p < 0.005). CONCLUSIONS: The presence of pretransplantation HBM in liver transplant recipients protects these patients against the development of de novo hepatitis B. This is especially important considering that there is a high prevalence of donors with positive hepatitis B core antibody (especially in some countries), and that these donors transmit HBV infection to recipients without HBM in a significant number of cases. Thus, vaccination against HBV in patients who are candidates for liver transplantation is fundamental to avoid cases of de novo hepatitis B.

Adult↗
PubMed1997

[Pharmacologic activity of the aqueous wood extract from Quassia amara (Simarubaceae) on albino rats and mice].

All the assays were done with an aqueous preparation of dry wood from Quassia amara (Simarubaceae). For the hippocratic assay, 12 female SDN rats were used, with an average weight of 144 g and separated in three groups of four individuals each. The dose used were 500 mg/kg and 1,000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration and the observation of the animals were done daily during nine days. Acute toxicity of the preparation was studied with 25 male NGP mice with an average weight of 20.13 g, in groups of five individuals per dose. The oral administration was carry out with the following doses: 250, 500, 750 and 1,000 mg/kg, the control group received 0.5 ml of distilled water. No sign of acute toxicity was observed at any dose. For the toxicity analysis via intraperitoneal injection 15 male NGP mice were assigned to five groups (5 animals each) with doses of 500 and 1,000 mg/kg and a control group with 0.5 ml of distilled water. The group with the dose of 500 mg/kg, presented acute toxicity signs with a 24 hr recovery, and the 1,000 mg/kg dose was lethal to a 100% within 24 hr. The measuring of the peristaltic activity (movement of the intestinal content) were performed on 30 NGP male mice with an average weight of 22 g assigned to three groups of ten individuals each. One dose of 500 mg/kg and 1,000 mg/kg were orally administrated to each experimental group and 0.5 ml of distilled water to the control group. The marker used was activated carbon, orally supplied to every mice 30 min after the administration of the aqueous extract. The animals are decapitated and the measurement of the carbon motion in the small intestine was done after 30 min. Both dose increased the intestinal movement compared to the control group, but only the 1,000 mg/kg dose showed a statistically significant difference (p < or = 0.05).

Animals↗
PubMed1997

[Regression of left ventricular hypertrophy in hypertensive patients].

Left ventricular hypertrophy associated with systemic hypertension differs from left ventricular hypertrophy initiated by other pressure overload diseases. Its development depends not only of hemodynamics aspects but of biochemical factors. Many studies have demonstrated a close link between left ventricular hypertrophy and cardiovascular morbidity and mortality. For that reason the idea of reversal of left ventricular hypertrophy has been a goal of the antihypertensive treatment. From the literature review has been established that the most classes of antihypertensive medications reduce the left ventricular mass, though there is a variation in required duration of treatment. At this point the angiotensin converting enzyme inhibitors, probably because a double effect: hypotensive and blockers of the trophic stimulus of angiotensin II, seemed to be the most potent for reducing the left ventricular mass. Still we don't know if reversal of left ventricular hypertrophy, by the antihypertensive treatment, reduce independently the cardiovascular risk.

Angiotensin II↗
PubMed1996

[Cardiovascular effects of aqueous extracts of the leaves of Clusia coclensis (Guttiferae)].

Aqueous extracts of the leaves of Clusia coclensis, (Guttiferae) injected intravenously to 42 normal Sprague-Dawley rats and to 42 Spontaneous Hypertensive rats, in 7 different doses, induced a rapid and transitory decrease in blood pressure and heart frequency. The magnitude of blood pressure decrease was dose-dependent. The effect was statistically significant (p < or = 0.01), probably due to sympathetic stimuli.

Animals↗
PubMed1994

[Droxicam-induced hepatitis. Description of 3 new cases and review of the literature].

Three new cases of cholestatic hepatitis caused by droxicam are described, along with a revision of the other eight cases published to date. Itching, asthenia, and jaundice were the most common symptoms. Average age was 62.8 years (range: 45-82 years), and the median time of exposition was 22.7 days (range: 5-50 days). Biochemistry of the liver showed primarily cholestasis and in 4/11 cases hypereosinophilia. Two patients presented elevated levels of cholesterol and triglycerides which disappeared within the month. Clinical manifestations persisted in one patient for eight weeks after the cessation of treatment. The three patients presented in the present series presented alteration in the biochemistry of the liver two months after initiation. Liver biopsy in three patients showed centrozonal cholestasis associated with portal inflammatory activity and presence of granulomas consistent with toxic hepatitis.

Aged↗
PubMed1992

[Treatment of residual choledochal calculi in patients with Kehr's T drainage: role and results of endoscopic sphincterotomy].

The results of sphincterotomy in the treatment of residual gallstones after cholecystectomy in a series of 62 patients, bearers of a T tube are reported. The mean time after surgery was 26.4 +/- 19.2 days. The procedure was technically successful in 59/62 (95.1%). Stones were passed spontaneously or were retrieved in 55/62 patients (88.7%). In four patients gallstones persisted in spite of sphincterotomy. All were operated with favorable results. Complications were observed in 4 patients (6.4%), without mortality. Sphincterotomy is a safe and relatively efficient technique in the treatment of cholecystectomized patients with residual gallstones and a T tube drainage.

Adolescent↗
PubMedDate not supplied

[Effects of Casimiroa edulis (Rutacea) on blood pressure and heart rate in albino rats].

Aqueous extracts of Casimiroa edulis leaves injected intravenously to 20 normal Sprague-Dawley rats produced a rapid and transitory increase in blood pressure. The amplitude of the blood pressure rise was dose dependent. The increase was statistically significant (p < or = 0.01) at a concentration of 220 mOsm/l, and was associated with a significant heart rate decrease (p < or = 0.01) probably secondary to barorreceptor stimuli. The application of 130 mOsm/l of the extract did not produce a significant increase in blood pressure, which was followed by a rapid pressure normalization. The slight increase in cardiac rate during the pressure lift was probably due to sympathetic stimuli.

Animals↗