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Biomedical subjects

M García Martínez

Publications and source records attributed to M García Martínez.

7 recordsLinked to original sources
PubMed2002

Beta-blockade and exercise capacity in patients with mitral stenosis in sinus rhythm.

BACKGROUND AND AIM OF THE STUDY: The study aim was to determine whether beta-blocker treatment (atenolol) improves cardiopulmonary exercise performance and ventilatory response in patients with mitral stenosis in sinus rhythm. METHODS: A prospective study comparing the results of cardiopulmonary exercise tests (CPETs) was performed before and after atenolol therapy in 17 patients in NYHA classes I and II with mitral stenosis in sinus rhythm. Transthoracic echocardiography was performed pre-study, and left ventricular diameters, ejection fraction and mitral valve area monitored. CPETs (Naughton protocol) were performed by two different investigators before and after one-week atenolol therapy (50 mg/day). The second investigator was blinded to the result of the baseline test. O2 consumption, CO2 production, ventilatory parameters and respiratory exchange ratios were measured on line. RESULTS: Maximal O2 uptake (VO2max) did not differ significantly before and after beta-blockade (median 16.8 and 15.0 ml/kg/min, respectively. Median heart rate at rest (72 versus 55 beats/min; p = 0.0003) and during peak exercise (153 versus 105 beats/min; p = 0.0003), and anaerobic threshold (10 versus 8.9 ml/kg/min; p = 0.02) were lower with beta-blockade compared with the baseline state. Minute ventilation at maximum exercise (41 versus 40 l/min) and ventilatory equivalent for CO2 (34 versus 35) were unchanged with atenolol therapy, indicating no improvement in ventilatory performance. When patients were grouped into those in whom VO2max was improved with atenolol therapy (n = 7) and those in whom it was impaired (n = 10), there were no inter-group differences with respect to age, left ventricular function, severity of mitral stenosis, NYHA class and grade of beta-blockade reached. Four patients felt symptomatically worse during atenolol treatment (lower NYHA functional class). CONCLUSION: Beta-blockade does not improve exercise tolerance in patients with mitral stenosis in sinus rhythm. In addition, ventilatory performance does not change with treatment.

Adrenergic beta-Antagonists↗
PubMed1997

[Heart insufficiency as first manifestation of familial primary hypothyroidism].

Heart failure is not a common manifestation of hypothyroidism if there is no underlying heart disease. We report a case of familial primary hypothyroidism in a young male, that clinically onset with dyspnea, hemoptysis and serum CPK elevation, and in which further explorations revealed a dilated cardiomyopathy due to hypothyroidism. Because of its bad prognosis, we underline the need to identify those cases of dilated cardiomyopathy that can be treated with the appropriate therapy.

Adult↗
PubMed1989

[Ovum donation and gamete intrafallopian transfer (GIFT): a new reproduction concept].

Gamete intrafallopian transfer (GIFT) was performed in 11 patients with premature gonadal failure and infertility, with oocyte donation. The sustitutive estrogen therapy with Estradiol Valerinate and Progesterone was maintained up to 100 days after the transfer. In all the cases GIFT was performed between the day 13 and 70 of the cycle. There were 5 pregnancies out of 11 cycles (success rate of 45.4%), one ended with a live child and the four others are on their first, second and third trimester. We are presenting a modified and simplified new protocol for hormonal replacement and our results suggest a new and wide "endometrial window" for the management of this patients. This results offer a promising future for patients with premature gonadal failure.

Adult↗
PubMed1989

[The empty follicle syndrome: a biologic reality].

Two patients were admitted to our Gamete Intrafallopian Transfer (GIF) program, and received and ovulation stimulation protocol with Clomiphene Citrate and human menopausal gonadotropin (hMG). Human chorionic gonadotropin (hCG, 10,000 IU IM) was administered when follicle size achieved 18 mm adn oocyte retrieval was scheduled after 36 hours. The estradiol levels in both patients were 1,127 pg/ml respectively at the time hCG was administered, which demonstrates an excellent response to the stimulation. Follicle aspiration was accomplished by transvaginal ultrasound-guided puncture or laparoscopy, and we were unable to recover oocytes in 17 follicles. Our findings support the existence of the "Empty Follicle Syndrome". This pathology may explain some of the infertility causes of our sterile population.

Adult↗
PubMed1989

[GIFT: reproductive reality for the sterile couple].

From June 1987 thru December 1988, 72 patients entered our gamete intrafallopian transfer (GIFT) program. The average age of our patients was 28 years with of infertility. The causes for being selected to the program were: Unknown (14), Endometriosis (14), Male (13), Ovarian (5), Cervical (9), Tubo-peritoneal (6) and oocyte donation (11). Different follicular stimulation protocols were used, with combinations of clomiphene citrate, human menopausal gonadotropins (hMG) and follicle stimulating hormone (FSH). Monitoring by serial ultrasound scanning until two or more follicles were 16-18 mm and estradiol levels were over 700 pg/ml, after which 10,000 IU of human chorionic gonadotropins (hCG) were injected. After 36 hrs oocyte retrieval was performed. There were 19 clinical pregnancies (26.4%). We feel that this new technique offers a bright and promising future for our infertile population.

Adult↗