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Biomedical subjects

M Gardziejczyk

Publications and source records attributed to M Gardziejczyk.

9 recordsLinked to original sources
PubMed1999

[Serum levels of interleukin 6 (IL-6) and soluble IL-6 receptor (sIL-6R) in children and adolescents with Graves-Basedow disease].

The concentration of interleukin 6 (IL-6), soluble IL-6 receptor (sIL-6R) and intercellular adhesion molecule-1 (sICAM-1) was assayed in 24 children with Graves' disease, aged 6.5-17 years, before treatment with methimazole, during clinical and biochemical remission (8 weeks), and following the eighteen-month therapy with the thyrostatic. ELISA method was used to determine the concentration of interleukin 6, sIL-6R and sICAM-1. An increase was observed in serum concentration of IL-6 and its receptor sIL-6R and soluble intercellular adhesion molecule-1 in the course of Graves' disease. A significant reduction in sIL-6R (8 weeks) and IL-6 (18 months) was noted after therapy with methimazole. A positive correlation was found between microsomal antibodies and the concentration of sICAM-1 and sIL-6R, and between antithyroglobulin antibodies and concentration of sIL-6R in children with fresh hyperthyroidism. No correlation was revealed between the level of thyroid hormones and the concentration of cytokines and adhesion molecules.

English Abstract↗
PubMed1999

[Pseudohypoparathyroidism in a 14-year old girl].

The authors describe the case of a 14-year old girl with pseudohypoparathyroidism, who showed characteristic phenotypic features of Albright's hereditary osteodystrophy (short stature, round face, mild obesity, abnormal position of teeth, lack of canines, limb valgity) and biochemical disturbances--hypocalcemia, hyperphosphatemia. The nature of pseudohypoparathyroidism consists in a lack of response to the parathormone of effector organs, such as kidneys, bones, alimentary tract. The treatment of choice includes active metabolites of vitamin D3, calcium salts, phosphate-binding components. Pseudohypoparathyroidism is a rare disease. Worth noting is the fact that it can occur in a child with height deficiency.

English Abstract↗
PubMed1998

[The analysis of exercise efficiency and autonomic function in children with nontoxic nodular goiter during suppressive L-thyroxine therapy].

UNLABELLED: The aim of the study was the analysis of exercise efficiency and the function of the autonomic system in children with a nontoxic nodular goiter (NNG) subjected to TSH suppression. The study comprised 17 children, aged 11-18 years, with NNG treated with suppressive L-thyroxine doses for 6-36 months (mean 24 months). Exercise efficiency was examined on a moving track according to the protocol of Bruce. Analysis of the autonomic function was based on functional tests of the circulatory system and monitoring of the QTc interval. A group of healthy children with a negative heart and thyroid history served as control. Statistically significant acceleration of the heart rate (p<0.01) was found in NNG patients subjected to TSH suppression, compared with controls. The remaining results included a fall in exercise efficiency parameters:work load (p<0.001) and duration (p<0.003), metabolic equivalent (p<0.005), and the maximal oxygen consumption index Vo2 (p<0.005) at normal values of double product. A significant decrease was revealed in the ejection fraction during exercise (61+/-1.9 vs 67+/-5.9 p<0.001) in the group of children with nontoxic nodular goiter. CONCLUSIONS: 1. In the subclinical state of hyperthyroidism no functional disorders were observed in the autonomic system, which controls the circulatory system. 2. Exercise tolerance was reduced in patients with nontoxic nodular goiter subjected to TSH suppression. 3. A relationship was found between the level of thyroid hormones (TSH, FT4) indicating the subclinical state of hyperthyroidism and the acceleration of heart rate, reduction in the ejection fraction of the left ventricle of the heart after exercise and shortening of load test duration. 4. Higher rest values of heart rate were observed in children treated with suppressive doses of L-thyroxine, compared with controls.

English Abstract↗
PubMed1998

[Polyglandular autoimmune syndrome in 14-year-old boy].

A case of polyglandular autoimmune syndrome (PGA) in a 14-year-old boy presented is. The case syndromes included hyperthyreosis with a high titre of antithyreoglobulin and antimicrosomal antibodies and hypofunction of adrenal glands confirmed by the test with ACTH. The boy was admitted to the clinic in an average general condition. Marked insufficiency of the body mass in comparison to the height, many pigmented moles on the skin and features of thyroid hyperfunction confirmed by laboratory examinations were observed. Thyreostatic and b-blocker were applied for treatment. The boy was discharged in the condition of clinical and biochemical euthyreosis. After two months of follow-up in the Endocrinologic Outpatient Department there was no weight gain, no appetite and general weakness. The anamnesis showed multiple faintings. The boy was hospitalized again. Suspecting adrenal hypofunction, a test with ACTH was carried out but it did not give any result. Substitutive treatment was applied resulting in a gradual improvement of the general condition and disappearance of complaints. The case is presented due to the rare incidence of the syndrome and due to the diagnostic difficulties.

English Abstract↗
PubMedDate not supplied

Serum levels of adhesion molecules in children and adolescents with immune and non-immune thyroid diseases.

Serum levels of sICAM-1, sVCAM-1 and sP-selectin were determined in patients with Graves' disease before and after 8 weeks and 24 months of methimazole therapy, in levothyroxine suppressed patients with non-toxic nodular goiter, and in a group of healthy controls, to elucidate the relationship to circulating antithyroid antibodies and possible role of soluble adhesion molecules as markers of inflammatory activity. sICAM-1, sVCAM-1, and sP-selectin in patients with untreated hyperthyroidism were markedly elevated compared with controls. After 8 weeks of methimazole treatment, the concentrations of these molecules dropped, but were still significantly higher than in healthy children. In patients with clinical and biochemical remission after 24 months of therapy, sICAM-1 values were on the verge of significance, but still higher than in the control group, whereas serum levels of sVCAM-1 and sP-selectin had normalized. Slightly higher serum sICAM-1 values were observed in patients with non-toxic nodular goiter compared with healthy children.

Adolescent↗