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Biomedical subjects

M Gargiulo

Publications and source records attributed to M Gargiulo.

69 records · Page 4Linked to original sources

[Incidence of cryoglobulinemia in a series of cases of chronic liver diseases].

The prevalence of cryoglobulinaemia in a series of patients with chronic liver disease from the Campania area has been studied. The series included: 14 cases of chronic persistent hepatitis (CPH), 70 cases of chronic active hepatitis (CAH) and 113 cases of liver cirrhosis. Liver function tests were carried out on the serum of each patient and cryoglobulines were studied. Liver biopsy was carried out when indicated. About a third of the patients were under the effect of previous treatment with anti-inflammatory steroids and-or azathioprine. Cryoglobulines were found in 4 of the 197 patients (2%); of type IgG in 3 cases: 1 of CAH, HBsAg negative and 2 of inactive cirrhosis of which one with HbsAg in the serum; of type IgM in 1 case of CAH, HBsAg negative. The data are discussed on relation to other reported data.

Adolescent↗

Educational benefits of the United States school feeding program: a critical review of the literature.

In the Child Nutrition Act of 1966 it was stated that educational progress was an objective of the United States School Feeding programs. In spite of this fact no serious attempt has ever been made to evaluate whether this objective has been met; the few evaluations that have been conducted lack scientific rigor. As a whole the studies fail to provide a strong basis from which to make valid inferences regarding the long-term effects of the feeding program on school achievement and adaptation. Studies that have focused on the short-term effects of hunger or morning feeding suggest that the provision of breakfast may both benefit the student emotionally and enhance his capacity to work on school type tasks.

Achievement↗

Parietal inflammatory infiltrate in peripheral aneurysms of atherosclerotic origin.

Clinical and histological analyses were made of 18 consecutive cases of peripheral artery atherosclerotic aneurysms (PAAA) (common, deep femoral and popliteal arteries) and compared to a group of 10 specimens obtained from the atherosclerotic, non aneurysmal femoral arteries of 10 cadavers with similar characteristics to the 18 patients. Although neither the clinical nor the macroscopic morphological data indicated the presence of an inflammatory process in the PAAA, the histological examination revealed the presence of a considerable infiltrate (greater than 11 inflammatory cells/2116 microns2) in a surprisingly high percentage of cases (4 cases, 22.8%). In 5 other cases (27.7%) the presence of lymphomonoplasmonocytic cells, although less pronounced, was greater than normally seen in atherosclerotic arterial walls (greater than 4 and less than 11 inflammatory cells/2116 microns2). The median number of inflammatory cells present in the media and adventitia varied from 2.2 +/- 0.3 to 13.2 +/- 0.3 per 2116 microns2. These values are significantly different compared to the results of atherosclerotic arteries at the same level (P less than 0.001 Mann-Whitney's U test). These findings of lymphomonoplasmocytic infiltrates in the absence of other pathology, together with an analysis of the data in the literature, makes it possible to presume that the inflammation present is associated with atherosclerosis and is more common in aneurysmal rather than stenotic forms. The pathogenesis may be determined by immune reaction phenomena.

Aged↗

Inflammatory abdominal aortic aneurysms: does an early stage exist?

Inflammatory aneurysms are characterised by a peculiar clinical (i.e. abdominal-lumbar pain, weight loss and increased ESR) and morphological picture (whitish wall, adhesion to the surrounding organs and thickness greater than 0.5 cm). The lymphomonoplasmacellular infiltrate and the interstitial deposits of collagen define the histological picture of these lesions. The authors describe three abdominal aortic aneurysms macroscopically characterised by parietal edema, hyperemia and hypertrophy of the preaortic lymphnodes. Histological study revealed a conspicuous and widespread lymphomonoplasmacellular infiltrate and interstitial edema. The abdominal-lumbar pain, the increase in ESR and the reactive C protein defined the clinical and laboratory aspects. Serological tests for syphilis, rheumatoid arthritis and lupus erythematosis were negative. The question which arises from these observations is whether these forms represent separate entities or an early stage in the evolution of inflammatory abdominal aortic aneurysms with fibrosis.

Abdominal Pain↗

Inflammatory aspects in atherosclerotic abdominal aortic aneurysms. A case report.

An important inflammatory reaction was histologically observed in the wall of an abdominal aortic aneurysm in a 42 year-old patient suffering from multifocal atherosclerotic lesions. Histochemical and ultrastructural studies showed an active-stage wall lymphomonoplasmacellular component. The histological appearance and biochemical and microbiological studies excluded specific aortitis, a rheumatic disease or concomitant infectious processes. The morphological relationships between the atherosclerotic lesion and the infiltrate together with the immunophenotyping features of the infiltrate suggest the possibility of a close correlation between the inflammatory process and the atherosclerotic lesion of the wall.

Adult↗

Angiosarcoma in a limb with arteriovenous fistulas and elephantiasis.

Angiosarcoma is a rare malignant tumor of the soft tissues (less than 1% of sarcoma). It may affect various parenchymae (bones, liver, breast), the soft tissues or the skin. In the latter case it may be associated with lymphedema. Onset in the arm is typical with postmastectomy lymphedema (Stewart-Treves syndrome). The forms occurring in limbs with chronic lymphedema not associated with mastectomy are much rarer, with a total of 38 cases occurring in patients with an average age of 46.8 years and with lymphedema present for an average of 20 years. The survival rate for 5 years is 16.6%. The case observed by us had the characteristic onset of the malignant neoplasm on a pre-existing "angiomatosis lymphangiomatosis" pattern also featuring angiographycally detected arteriovenous fistula.

Adolescent↗

Angiographic evaluation of the anatomic pattern of arterial obstructions in diabetic patients with critical limb ischaemia.

OBJECTIVE: The present study was undertaken to evaluate, by means of angiography, the anatomic pattern of arterial obstructions in the lower extremities of diabetic patients presenting with critical limb ischaemia. We particularly examined the differences in involvement of the foot arteries between patients with and without diabetes. PATIENTS AND METHODS: A group of 150 patients with limb-threatening ischaemia, manifested by rest pain and/or non-healing ischaemic ulcers or gangrene, underwent angiologic evaluation in prevision of vascular surgery. The patients, of whom 89 were suffering from diabetes, were examined by means of digital subtraction angiography using the Seldinger technique. In each patient, details of arterial tree were obtained from the aortoiliac to the foot arteries and the site and the extent of obstructions were determined blindly with the radiologist unaware of the patient's history of diabetes. RESULTS: Diabetic patients showed significantly more obstructions in the infrapopliteal arteries when compared to the patients without diabetes who had more pronounced involvement of aortoiliac and femoropopliteal arteries. Diabetic patients, moreover, showed a higher prevalence of obstruction in posterior tibial, peroneal and plantar arteries than the non-diabetics. At the time of presentation, the age of patients did not differ between the two groups but diabetic patients had more frequent ischaemic ulcers or gangrene and less rest pain than the non-diabetics. CONCLUSIONS: Our study confirms earlier reports carried out with non-angiographic methods indicating more frequent involvement of calf arteries in diabetic patients but disagrees with those which report that patients with diabetes have less occlusive disease in foot arteries.

Adult↗

[Anomalies of the subrenal inferior vena cava in the surgery of non-specific and inflammatory abdominal aortic aneurysms].

The sub-renal abnormalities of the lower vena cava (LVC) (left LVC, double LVC) are determined by a deterioration of the alteration process of supra-cardinal veins. Though they are rare, it is necessary to look for them during surgery of abdominal aorta in order to lower the risk of iatrogenic venous injuries. You will find below the description of six cases of sub-renal lower vena cava abnormality (3 double LVC, 3 left LVC) associated with an abdominal aorta aneurism (4 non specific aneurisms, 2 inflammations ones) as well as the diagnostic aspects and the technical issues they cause during the reconstruction of a non specific and inflammation aneurism of the abdominal aorta.

Aortic Aneurysm, Abdominal↗

[Paget disease of the jaws. Review of the subject. Clinical-therapeutic considerations].

Clinical and diagnostic findings of Paget's disease of the jaws are reported; up to date etiological and pathogenical hypotheses are presented. Laboratory data of increased P.A. as a marker of disease evolution is pointed out, particularly the relationship increasing hydroxyprolinuria, because the increase of a malignant transformation. Surgery, always modeling, is limited to cases of severe facial dysmorphosis associated or not with the local disturbance due to compression; in any case it is suggested to perform the surgery in the phases of inactivity of disease, to avoid local complications, such as hemorrhage a infection.

Adolescent↗