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Biomedical subjects

M Gargouri

Publications and source records attributed to M Gargouri.

At least 19 recordsLinked to original sources
PubMed2006

Vibrational study of [(CH3)4N]2Cu0.5Zn0.5Cl4.

[(CH3)4N]2Zn0.5Cu0.5Cl4 shows an orthorhombic system at ambient temperature with P2(1)nb space group. At room temperature, the crystal consists of three sublattices constituted by MCl4 (M=Cu and Zn) and two tetramethylammoniums N1(CH3)4 and N2(CH3)4, which give rise to a total of 372 vibrational modes that transform according to the four irreductible representations of the C2v point group in the following way: Gamma(vib)=93(A1+A2+B1+B2). The infrared and Raman spectra of polycrystalline samples have been investigated at room temperature. The assignment of the observed bands is discussed.

Chlorides↗
PubMed1997

The kinetic behaviour of a two-enzyme system in biphasic media: coupling hydrolysis and lipoxygenation.

Analysis of the kinetic behaviour of a two-enzyme-system carrying out two consecutive reactions was investigated in macroheterogeneous biphasic media (octane/buffer pH 9.6, v/v = 1:1). The lipase-catalysed hydrolysis of trilinolein and the subsequent lipoxygenation of the liberated linoleic acid, were coupled in a modified Lewis cell with a well-defined liquid/liquid interfacial area. Trilinolein was dissolved in the organic phase and hydrolysed in the presence of Mucor javanicus lipase at the organic/aqueous interface. Linoleic acid, liberated after hydrolysis was transferred to the aqueous phase and reacted with lipoxygenase. This reaction consumed linoleic acid and produced hydroperoxides, which favoured the transfer of residual linoleic acid, since they possess surface active properties. Catalysis and transfer influenced each other reciprocally. At low substrate concentrations, cooperativity phenomena were observed in the experimental and also the modelled two-enzyme systems. When the initial substrate concentration was high, the kinetic behaviour of the two-enzyme system in a compartmentalised medium, seemed to be independent of the substrate concentration, unlike that observed in homogeneous monophasic enzymology. The numerical integration program used to model the two-enzyme system was based on results obtained in separate studies of the following three phenomena: (1) trilinolein hydrolysis in biphasic medium. (2) linoleic acid transfer across a liquid/liquid interface and (3) lipoxygenation in an aqueous media. Results obtained by modelling were similar to the results observed experimentally.

Hydrolysis↗
PubMed1986

[Trial therapy of inoperable abdominal hydatid cysts by puncture].

Hydatidosis is a major public health problem in Tunisia. The infection rate in the normal population is over a 100 times higher than in the generally accepted hyperendemicity level (1,720 in 100,000 as against 13 in 100,000!). The use of drugs of benzimidazole derivates prevents the development of scolices into hydatic cysts and allows to try a non-surgical cure by the punction of hydatid cyst of the sheep liver, i.e. aspiration of the cyst fluid and injection of hypertonic salt solution into the drug treated animal. The good results obtained in a group of 16 animals permitted us to apply this method to two patients whose conditions made surgical intervention dangerous. The results although excellent in the case of a secondary peritoneal cyst were less spectacular in the case of secondary liver cyst of whose wall showed signs of involution.

Animals↗
PubMed1985

[Primary, exclusively gastric localization of alpha-chain disease: anatomo-clinical and immunohistochemical study].

We report the first case of heavy alpha-chain disease exclusively located in the stomach and in the perigastric nodes in a thirty year old Tunisian patient. Both the small bowel and the mesenteric nodes were evaluated histologically and immunochemically and were found to be free of disease. Complete remission was obtained using chemotherapy. The reasons for which the small intestinal mucosa and the mesenteric nodes, nearly constantly involved, in alpha-chain disease were spared in our case, are discussed.

Adult↗
PubMedDate not supplied

Percutaneous treatment of hydatid cysts (Echinococcus granulosus).

A new method called PAIR (Puncture-Aspiration of cyst contents--Injection of hypertonic saline solution--Reaspiration) was used as a percutaneous treatment of hydatid cysts. In 37 patients, 120 cysts were punctured. All patients had not been considered surgical candidates. The cysts were localized in the liver, peritoneum, spleen, kidneys, muscles, and bones. In 70% of patients, good results were obtained. Recurrence occurred in 5 of 120 cysts, all at the beginning of our experience when a low concentration of sodium chloride solution was injected. Moderate allergic reactions occurred during seven cyst aspirations. No anaphylactic shock, sudden deaths or dissemination of cyst contents were observed.

Adult↗