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Biomedical subjects

M Gauthier

Publications and source records attributed to M Gauthier.

136 records · Page 8Linked to original sources
PubMed1968

[A new anesthesia].

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Anesthesia, Dental↗
PubMedDate not supplied

Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization.

Large uniform-sized polymer beads are desirable for "one-bead-one-compound" applications in the combinatorial synthesis of compound libraries. We have developed a technique for the preparation of large polymer spheres with narrow size distributions. Uniform-sized poly(styrene-co-divinylbenzene) beads with diameters in excess of 1 mm have been prepared by free radical polymerization in an ascension process through a heated column. The size of the beads can be adjusted by the diameter of the injection needle and the injection speed. The resin beads can be made porous by the incorporation of a porogen during the preparation; they reach a specific surface area in excess of 200 m(2)/g. The mechanical properties of the spheres and their use in organic synthesis have been studied.

Combinatorial Chemistry Techniques↗
PubMedDate not supplied

Peracute streptococcal pyomyositis: report of two cases and review of the literature.

Pyomyositis occurs infrequently in temperate climates. The fulminating peracute form caused by group A Streptococcus is exceedingly rare. We present two children with streptococcal pyomyositis. One child was admitted in septic shock and required intensive supportive care during the acute stage of his illness. Persistent swelling and tenderness of his left thigh presented a diagnostic problem, which was eventually resolved with the aid of computerized tomography. Despite appropriate antibiotic therapy from the onset of illness, surgical debridement of the affected muscle was necessary. The second child presented with pyomyositis of the left paravertebral muscles and signs of incipient shock but did well on antibiotic therapy alone.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Survey of "Neisseria gonorrhoeae" sensitivity to antibiotics by dilution and diffusion methods using a new medium (author's transl)].

Usual media are not convenient for the determination of minimal inhibitory concentrations (MIC). An agar medium without haemoglobin and seric proteins (ABNG) is proposed. Using the dilution method with less fastidious bacteria, including Neisseria sp., MIC were identical on Mueller-Hinton agar and ABNG. By using diffusion techniques, the correlation was good between MIC and zone diameters; the density of inoculum for gonococci was 2 x 10(6) CFU/ml. Dilution and diffusion techniques were used for penicillin, ampicillin, thiamphenicol, tetracycline and spectinomycin. It appears that the diffusion technique with ABNG medium would simplify the antibiotic sensitivity survey for N. gonorrhoeae, dilution technique remaining the reference method.

Anti-Bacterial Agents↗