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Biomedical subjects

M Gay

Publications and source records attributed to M Gay.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Evolution of the storage site of iron-dextran after retrograde axonal transport in the rat central nervous system (author's transl)].

The uptake, transport, and storage of an iron-dextran complex (used as a neuroanatomical tracer in the nigrostriatal pathway of rat) by neurons of the CNS is described. The complex is taken up by endocytosis and transported by lysosomes. Some iron-containing mitochondria are observed within the nigral cell bodies. The neuronal labelling remains for 10 days. Thereafter, the iron labelling of neurons decreases. No important neuronal degeneration is observed as a result of iron toxicity. The iron lost by neurons is taken up by glial cells. It is converted into ferritin and increases the intracerebral endogenous iron content.

Animals↗
PubMed1979

[Application to the study of connections in the CNS of the retrograde axonal transport of an iron-dextran complex].

The retrograde axonal transport of an iron-dextran complex was observed in neurons of the substantia nigra and of the intralaminar nuclei of the thalamus, after previous injection into the striatum. The histochemical demonstration of iron is simple and rapid, and can be combined with that of horseradish peroxidase, under precise conditions in the sequence of reactions. The iron-dextran complex revealed to be a valuable material for neuronal connectivity studies in the central nervous system.

Animals↗
PubMed1978

[Simple technic for culture of locus coeruleus nucleus in the newborn mouse].

The dissecting procedure and tissue culture technique on collagen coated coverslips in Leighton tubes, of newborn Mouse nucleus locus coeruleus and the regular histofluorescence demonstration of catecholaminergic fibers in the outgrowth zone are described. This simple method allows 10 day--long experiments .

Adrenergic Fibers↗
PubMed1978

Perinatal changes in plasma and adrenal corticosterone and aldosterone concentrations in the mouse.

The concentrations of corticosterone and aldosterone in the plasma and adrenal glands of foetal, newborn and mother mice were estimated during the last 4 days of pregnancy and throughout the perinatal period. The level of corticosterone in the maternal and foetal plasma fell from day 17 of gestation until birth, and then remained stable. Whereas the corticosterone content of the maternal adrenal glands did not change significantly, that of the foetal adrenal glands reached a peak on day 19 of gestation. At every stage of gestation, the level of corticosterone in the maternal plasma was higher than that in the foetus. Changes in the concentration of aldosterone in the foetal plasma and adrenal glands were similar and characterized by peak values at birth. In the mother during the last 4 days of pregnancy, the level of aldosterone in the plasma was higher than in non-pregnant mice, but lower than that in the foetus.

Adrenal Glands↗