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Biomedical subjects

M Gellért

Publications and source records attributed to M Gellért.

8 recordsLinked to original sources
PubMed1994

[Etiology of epidemic parotitis].

Blood samples of 204 acute parotitis patients in a fifteen month period (1991-1992) were systematically examined for IgM, IgA, IgG antibodies of mumps and parainfluenza-virus 1, 2, 3 (PIV) by immunofluorescent test (IFT) and, in special cases several other virological examinations have been done. The etiological role of mumps-virus, parainfluenza-virus 1, 2, 3, one of the other viruses was confirmed in 76.0%, 1.5%, 6.3%, 1.5%, 4.9% of the cases, respectively. The etiology remained unknown in 9.8%. There were clinical symptoms of meningitis or orchitis in some and lymphadenopathy in several of the parainfluenza-virus caused parotitis patients. The authors conclude, that the parainfluenza-viruses are the second most frequent etiological agents of parotitis next to mumps-virus. They found that the Respiratory Syncytial Virus (RSV) also play etiological role in parotitis. This observation should be confirmed in the future by some other kind of virological tool too. The authors call attention to the difficulties and pitfalls of the virological serology in the infections caused by paramyxoviruses (PMV).

Adolescent↗
PubMed1982

Double labelled T suppressor lymphocytes in the thymus of a patient with myasthenia gravis: morphological and immunological characteristics.

Double labelled lymphocytes were prevalent in the thymus of a 32-year-old woman with myasthenia gravis. The simultaneous presence of both E and C3b surface receptors was demonstrated. Focal paranuclear acid phosphatase activity of the cells supported their T cell origin. Histological analysis revealed a hyperplastic thymus with germinal centres in one lobe and an unusual transition to "thymoma-like" diffuse sheets of thymocytes and large thymic epithelial cells in the other lobe. Immunological studies of isolated cells from the "thymoma-like" region revealed a high percentage of E rosettes (96%), EAC rosettes (87%) and IgG-EA rosettes (60%). The large number of "active" rosettes (94%) indicated high avidity of receptors for sheep red blood cells. The postoperative accumulation of acid phosphatase positive T cells with C3b surface receptors in the peripheral blood was striking. These characteristics suggest that this cell population represents an activated T subset (TG) with a certain degree of immaturity similar to a particular stage of foetal T cell development (prothymocytes).

Adult↗
PubMed1975

[Electron microscopic study of striatodental calcification (Fahr) (author's transl].

In a woman, aged 52, who had impaired phosphate excretion and low serum calcium levels, abundant calcium deposits (Pseudokalk) were found between the basement membranes of blood vessels in the regions of corpus striatum and nucleus dentatus as well as in the subcortical white matter and centrum semiovale. Calcium deposits were found also outside blood vessels but always in the vicinity of the basement membrane. These can be phagocytozed by makrophages or astrocytes. Calcium deposits have a characteristic ultrastructure. They are built up of 140-400 A electron lucent filaments (acid mucopolysaccharid?) within which electron dark segments built up of 40-80 A units (calcium deposits?) are found. The concentric rings of calcified deposits are of reflection of differing density of aggregation of dark filaments. The growth of the deposits takes place by additional precipitation. In the development of calcification of the cerebral blood vessels in Fahr's disease, the role of high serum phosphate levels, the increased permeability and dysfunction of mesenchymal cells of the vessel walls are discussed.

Autopsy↗