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M Gen

Publications and source records attributed to M Gen.

10 recordsLinked to original sources
PubMed1995

[Effects of bisphosphonates on vitamin A-induced bone resorption in thyroparathyroidectomized rat].

A bone resorption model in which osteoclasts were selectively activated was made by administering vitamin A--a bone resorption agent--to juvenile thyroparathyroidectomized rat. Inhibition of bone resorption by YM-175--a third generation bisphosphonate--was studied using this model based on bone histomorphometry of the proximal part of the tibia and on biochemical data. Six-week-old male SD rats were thyroparathyroidectomized (TPTX). On the 11th day following TPTX they were treated with vitamin A (etretinate). In the calcitonin group, salmon calcitonin or its vehicle was added, and in the bisphosphonate group, YM-175 or its vehicle was added. They were sacrificed on the 21st day following TPTX. Calcitonin was used to confirm its inhibitory activity of bone resorption in this model. Cancellous bone in the epiphysis was subjected to histomorphometry using tetracycline labeling or TRAP staining, and the number of primary trabeculae at the metaphysis was counted to evaluate bone resorption activity. Serum calcium, phosphorus, urinary calcium, phosphorus, pyridinoline and deoxypyridinoline were measured for biochemical analysis. YM-175 did not change any bone formation parameters in the histomorphometry of the epiphysis, while it significantly decreased resorption parameters both histomorphometrically and biochemically. Primary trabeculae at the metaphysis were found to be longer and denser after administration of YM-175. The effect of YM-175 as a bone resorption inhibitor was observed even in a short duration experiment. There was no damage to mineralization, and no inhibiting effect was observed on bone formation. Similar results were observed by calcitonin. YM-175 was concluded to be an inhibitor of bone resorption caused by vitamin A administration.

Animals↗
PubMed1987

Primary myxoma in the pituitary fossa: case report.

A case of primary myxoma in the pituitary fossa is described. The tumor presented as an intrasellar and suprasellar mass and was successfully removed during a transsphenoidal operation. It was verified as a myxoma by histopathological studies, and there was no evidence that it was a metastasis. This is thought to be the first report of this tumor occurring in the pituitary fossa.

Adult↗
PubMed1984

Necrotic changes in prolactinomas after long term administration of bromocriptine.

Six prolactinoma patients were studied endocrinologically and their tumors were examined histologically after long term bromocriptine therapy. In patient 1 with a large prolactinoma, a marked reduction in size and a remarkable decrease in elevated serum PRL levels occurred after bromocriptine treatment for 8 months. The histological findings consisted of two components, i.e. shrunken island-like cell nests and acellular spaces. Some degenerative and necrotic tumor cells, hyaline substance, and fibrosis were observed with light and electron microscopy in these acellular spaces. Island-like cell nests consisted of atrophic cells having disproportionally scanty cytoplasm. The same histological findings were observed in four other patients. However, in another patient whose tumor decreased in size only slightly during bromocriptine therapy, the specimen had few acellular spaces. Thus, long term bromocriptine treatment of patients with prolactinomas may result in necrosis of some adenoma cells in some patients.

Adolescent↗
PubMed1984

[A case of internal carotid dolichoectasia].

A 50-year-old woman noticed right motor and sensory paralysis in the morning of December 15, 1978, which improved gradually to be able to walk during 20 days. She had recurrence of incomplete paralysis of right extremities with speech disturbance and admitted to our department on April 7. Neurological examination revealed right hemiparesis. Plain skull rentogenorgram showed a calcification extending posteriorly from the left anterior clinoid process. CT scan showed a mass lesion located at the left frontal lobe to the ambient cistern. The mass lesion showed high density, but its midportion was isodensity. The left carotid angiogram demonstrated abnormally curved, tortuous and dilated internal carotid artery at the intracavernous portion (C3) to bifurcation (C1). The cerebral circulation time was greatly delayed, which regained about 6 seconds for the visualization of the distal portion of the middle cerebral artery. On the basis of the above, we considered that the first right hemiparesis was due to emboli produced in the dolichoectasia and the following progressive stroke was attributable to the low perfusion demonstrated by a great delay of circulation time. The operation was performed to trap the dolichoectasia after STA-MCA anastomosis. However, trapping procedure was very difficult because of hardness of the distal portion of the involved artery. Therefore, surgery was concluded with STA-MCA anastomosis and only proximal internal carotid clipping. The postoperative angiography demonstrated well functional anastomosis and obliteration of dolichoectasia. She discharged on improvement of her condition on the 23rd day after operation. CT scan performed 6 months after operations showed the mass lesion to have become definitely reduced in size. The application of bypass surgery to the internal carotid dolichoectasia was reported with review of the literatures.

Brain Ischemia↗
PubMed1982

[A case of aspergillotic meningoencephalitis associated with trigeminal neuralgia].

A case of aspergillotic meningoencephalitis associated with trigeminal neuralgia was reported. The patient, a 41-year-old female, was admitted to our hospital on Nov. 20, 1977 with the chief complaint of right trigeminal neuralgia. On admission right facial paresthesia and right abducens palsy were found. The skull x-ray and tomogram showed enlargement of the right superior orbital fissure. Ct scan revealed an irregular high density around the right superior orbital fissure. The examination of spinal fluid showed 75 mg/dl protein, 72 mg/dl sugar and 11 cells. A biopsy of the mass and trigeminal rhizotomy were performed on Dec. 21, 1977. Microscopically, the specimen was composed of nonspecific granulomatous inflammatory tissue. Thereafter, loss of visual acuity, total ophthalmoplegia and facial paresis gradually appeared on the right side with high fever elevation. Immunologically, peripheral blood lymphocytes responded normally to PHA and PWM, but numbers of lymphocytes showed a tendancy of decrease with deterioration. On the other hand, serum IgG and IgM levels were rather increased. CT scan showed that an irregular high density mass extended to the right orbital apex and the pterygoid fossa. Spinal fluid revealed 260 mmH2O pressure with 76 mg/dl protein, 55 mg/dl sugar and 293 cells, but no organisms were demonstrated. Four months after the operation, swelling of the right subtemporal region became remarkable, in which region a puncture revealed much pus retention, and Aspergillus fumigatus was cultured from the aspirated pus. The patient became comatose and died on May 20, 1978. Autopsy showed thick, yellowish green pseudomembranes covering from the right temporal tip to the basal cistern. The both of cerebral hemispheres were swollen and revealed multiple small softenings all over the brain. Small hemorrhage occupying the right temporal subcortex and microabscess located in the left thalamus were also seen. Microscopical examination disclosed that the pseudomembrane was composed of the necrotizing suppurative inflammation with branched septate hypha of Aspergillus. There have been a few reports of aspergillotic meningoencephalitis associated with trigeminal neuralgia and enlargement of the superior orbital fissure like this case. Some discussion was made on the importance for the diagnosis of aspergillosis to perform fungal culture and histological examination of materials obtained from the inflammatory site, and immunological data of this case was also presented.

Adult↗