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Biomedical subjects

M Ghiţescu

Publications and source records attributed to M Ghiţescu.

18 recordsLinked to original sources
PubMedDate not supplied

Early prognosis of survival or death after a recent stroke by blood levels of acute-phase proteins.

From 129 patients with a recent stroke 105 survived and 24 died within 3 weeks from stroke-onset. At around 40 hours after the latter, the blood-levels of the acute-phase proteins ceruloplasmin and albumin did not forecast the death of the respective patients, but, in contradistinction, the level of fibrinogen was significantly higher in those who eventually died, than in those who survived. Therefore, a higher level of fibrinogen could be a risk-factor for death after stroke.

Acute-Phase Proteins↗
PubMedDate not supplied

Chlorpromazine-induced decrease of red cell aggregability.

Starting from the assumption that binding of chlorpromazine to the erythrocyte membrane might influence th rheology of these cells, the authors studied erythrocyte aggregability and deformability by means of a filtrability test in 42 neurotics and 16 patients with personality disorders, all males, aged 20 to 27 years, clinically healthy from the somatic view point. Determinations were carried out before and 30 min after a single i.m. dose of 1 mg/kg b.w. chlorpromazine (14 patients) and before and after a 5-day oral treatment with 3 mg/day haloperidol (11 patients) or 75 mg/day chlorpromazine (33 patients). Chlorpromazine induced a significant decrease of erythrocyte aggregability after 5 days of oral treatment (p less than 0.02) the effect being more marked in the patients with relatively high initial values (p less than 0.01). The mechanism of this phenomenon and its possible implications of ESR determination and in the therapy of occlusive vascular diseases are discussed.

Adult↗
PubMedDate not supplied

[Normal values of the neutrophil granulocyte adhesion test in the peripheral blood of adults].

After emphasizing the importance of adhesion of cells to a substrate as fundamental biological phenomenon, the authors discuss recently published data concerning adhesion of human neutrophil granulocytes and the clinical implications of its deficiency, showing the method developed in the Center of Haematology, Bucharest, based upon the Taga-Sturdza procedure and the works of Gifford and Malawista. The study included 82 young healthy subjects. The normal mean adhesion index in women was 5.10 +/- 0.34 and in men 4.61 +/- 0.27; the statistical difference between the sexes is not significant. The proportion of NBT-positive adherent cells was 40--60% in both groups.

Adolescent↗