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Biomedical subjects

M Ghorbal

Publications and source records attributed to M Ghorbal.

11 recordsLinked to original sources
PubMed1995

[Regressive bilateral retinoblastoma. Clinical and genetic study. Apropos of a case].

The authors report the observation of a 35-year-old patient, mother of 5 children 4 of whom are carriers of bilateral retinoblastomas. Two of these children presented lesions suggestive of retinoma retinoblastoma association. The patient had peripheral retinal lesions evoking the diagnosis of regressive bilateral retinoblastoma. At present, the term retinoma or retinocytoma seems to be more adequate. The genetic study of this family was done with D esterase and DNA molecular biology.

Adult↗
PubMed1994

Three-dimensional planar and vector analysis of brainstem auditory evoked potentials as a function of intensity in guinea pig.

Brainstem auditory evoked potentials (BAEPs) have been studied in guinea pigs as a function of intensity by means of the Three-channel Lissajous' trajectory (3-CLT) method. Data were quantified in terms of duration, orientation of planar segments and orientation of equivalent dipoles. The auditory stimulus was a click varying from 48 dB pSPL to 108 dB pSPL by steps of 10 dB pSPL. A semi-automated procedure was used to identify planar segments, by calculating the curvature (apex) and magnitude curves. Dipole analysis was made at the corresponding magnitude peaks and apices. Taking into account a symmetrical orientation of planar segments and equivalent dipoles, similar results were obtained after right and left stimulation. Six planar segments, A, B, C, D, E, F were analysed as were six equivalent dipoles corresponding roughly to P1, N1, P3, N3, P4 and N4 on a vertical lead. There was a parallel latency shift of the first and last point of planar segments as a function of intensity, accounting for the stable duration of a planar segment. Planar segment D (roughly corresponding to N3 on a vertical lead) disappeared as the intensity decreased. Only planar segments C and F and dipole N3 showed a significant change in their orientation. The stable duration of planar segments suggests that intensity coding in the auditory brainstem, in terms of a global function of a system, involved the same number of synapses in a serial circuit while the activated neurons increase in the in parallel circuitry, as the intensity increases. Similar changes in orientation of planar segments C (including P3 of guinea pig BAEPs) and F (including N4 of guinea pig BAEPs) suggest a possible common source with a depolarization followed by a repolarization.

Acoustic Stimulation↗
PubMed1991

[Familial form of gelatin drop corneal dystrophy].

We report 4 cases of gelatin drop dystrophy corneal amyloidosis in two brothers and two sisters of the same family. The age of onset is between 1 and 10 years. The corneal signs are described at different stages of development. Lesions are initially asymmetrical. The typical is a subepithelial nodule starting in the center and then expanding to involve the whole cornea. There is no relationship between extension and outcome of the disease. Diagnostic is confirmed by histological examination. There was no consanguinity between parents and no other cases were found in the family. An immunological study with HLA typing was performed. All patients were treated with lamellar or transfixing keratoplasty with a follow-up of 2 to 5 years.

Adolescent↗
PubMed1990

[Toxocara canis in apparently bilateral ocular site].

The authors report a rare case of ocular larva migrans lesions due toxocara canis in an 8-year-old child. Lesions were bilateral, consisting of peripheral chorioretinal granuloma, papillitis and vasculitis. Diagnosis was confirmed by eosinophilia (37%), positive serology in blood and aqueous humour and by raised immunoglobulins E in vitreous humour. The presence of vascular and chorioretinal lesions was demonstrated by fluorescein angiography. The patient was treated with antihelminthic drugs, topical and systemic steroids and ocular cryotherapy to the peripheral chorioretinal granuloma. The outcome was good, with lesions stabilised.

Child↗
PubMedDate not supplied

Antiphospholipid syndrome and retinal vein occlusion in adults.

Antiphospholipid antibodies may play and important role in the pathogenesis of retinal vascular occlusions; investigated the prevalence among 33 patients with retinal vein and artery occlusions and 80 controls. Prevalence was 33% and 5% respectively. Ophthalmic examination and fluorescein angiography showed that occlusions were due to ischaemic events. The 11 patients were diagnosed with antiphospholipid syndrome: 9 patients were treated successfully with laser photocoagulation and anticoagulant and anti-aggregant therapy. Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. Our results suggest a correlation between antiphospholipid syndrome and retinal vein occlusions; we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy.

Administration, Oral↗