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Biomedical subjects

M Giffin

Publications and source records attributed to M Giffin.

3 recordsLinked to original sources
PubMed1994

Effect of Nd:YAG laser on wound contraction and epithelial regeneration in rabbits.

This study was undertaken to objectively compare healing rates in wounds produced by the Nd:YAG (Neodymium:Yttrium-Aluminium-Garnet) laser to those caused by steel scalpel, in rabbits. Rates of contraction and epithelialisation in standard wounds were determined by daily measurement of the wound area from the time of wounding until epithelialisation was complete. The wounds were of three types: superficial to the panniculus carnosus, deep to it and ear wounds. Significant delays in both wound contraction (p < 0.0001) and epithelialisation (p < 0.0001) were demonstrated in all Nd:YAG laser wounds. Normal epithelial regenerative capacities were observed. The final appearance of the healed areas was comparable across the laser and scalpel groups.

Aluminum↗
PubMed1988

Lysophosphatidylcholine metabolism and cardiac arrhythmias.

The ability of exogenous lysophosphatidylcholine (LPC) to produce electrophysiological abnormalities in cardiac tissues and cardiac arrhythmias in isolated hearts has been well documented. In this study, the arrhythmogenic nature of LPC in the rat, rabbit, and guinea pig hearts was studied. The rat heart was found to be the most susceptible to LPC-induced arrhythmias, while the guinea pig heart was the least susceptible. Perfusion with labelled LPC revealed that the severity of arrhythmias correlates well with the amount of labelled LPC found in the microsomal membrane. The biochemical basis for the differences in the accumulation of LPC in the microsomal membrane of different animal species was investigated. Our results strongly indicate that the LPC level in the microsomal membrane may be regulated by the activity of microsomal lysophospholipase.

Animals↗