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Biomedical subjects

M Gille

Publications and source records attributed to M Gille.

25 records · Page 2Linked to original sources
PubMed1993

[Central pontine myelinolysis with cerebellar ataxia and dystonia].

A 46-year-old alcoholic woman presented with dementia, chronic cerebellar ataxia and diffuse dystonia. Neurological examination also demonstrated emotional lability and a pyramidal signs on the four limbs. CT showed mild cerebellar and frontal atrophy. The diagnosis of central pontine myelinolysis was confirmed by MRI. The centropontine lesion gave an hyposignal on T1-weighted sequences and a hypersignal on T2-weighted sequences. It was shaped as a trident and symmetrical, sparing the tegmentum and the ventro-lateral regions of the pons. Cerebellar ataxia was related to cerebellar atrophy and extension of myelinolysis to the middle cerebellar peduncles. Dystonia, rarely reported in central pontine myelinolysis, was not associated with striatal lesions on MRI. The pathophysiology of these movement disorders in central pontine myelinolysis remains unclear. This case shows that central pontine myelinolysis is a rare cause of dystonia and can be diagnosed by MRI.

Alcoholism↗
PubMed1990

[Neurological involvement as manifestation of Behçet's disease. 4 clinical case reports].

We report four patients with Behçet's disease characterized by initial and predominant neurological signs and symptoms. In three cases, a clinical picture of relapsing meningoencephalitis preceded the appearance of the classical signs of the disease for several months or years; in the fourth case, an acute febrile aseptic meningitis coincided with the development of bipolar aphthosis and uveitis. Disease activity was linked to a blood inflammatory syndrome and neutrophilic leucocytosis. Acute phases were associated with CSF mixed pleocytosis and high protein content. Brain CT scans and MRI were very effective to detect lesions which are mainly located in the brain stem and basal ganglia. High-dose corticosteroids and, in cases of relapses, immunosuppressive drugs were required to treat these severe forms of Behçet's disease.

Adult↗
PubMedDate not supplied

Isolated deep cerebral venous thrombosis diagnosed on CT and MR imaging. A case study and literature review.

Cerebral venous thrombosis represents less than 5% of all strokes. Isolated cerebral deep venous thrombosis is very rare. We present a case of isolated thrombosis of the internal cerebral veins and the vein of Galen diagnosed on CT and MRI, and we review the literature. We emphasize the pathognomonic signs on CT and MRI necessary for an early diagnosis obviating conventional angiography. Early diagnosis and treatment may avoid potentially devastating consequences.

Cerebral Veins↗
PubMedDate not supplied

[Vascular headache, thrombopenia and serotonin metabolism].

The role of platelet serotonin in migraine remains a subject of controversy. However, the frequency of association of migraine with antibody-mediated thrombocytopenia would suggest that platelet dysfunction or impaired serotonin metabolism might play a role in migrainous attack. We report three new cases, two involving chronic idiopathic thrombocytopenia and one lupus. The observation of high levels of anti-platelet antibodies in close correlation with the occurrence of attacks suggests that the Serotonin Releasing Factor (SRF) could be concerned. This was suspected previously on the basis of in vitro studies. The hypothesis that other forms of migraine might be linked to an immunopathological process involving other immunoglobulins is proposed (Acta neurol. belg., 1988, 88, 290-296).

Adult↗
PubMedDate not supplied

[Kufs disease with leukoencephalopathy].

We report a case of adult neuronal ceroid lipofuscinosis (Kufs' disease) with leukoencephalopathy on cerebral scan CT and MRI. A 52 year-old woman presented with partial complex epileptic seizure followed by progressive dementia, cerebellar ataxia, pyramidal and akineto-rigid signs and symptoms. After 6 years of evolution, cerebral stereotactic biopsies showed a diffuse gliosis of the white matter, but no clear demyelination. Nerve and glial cells contained numerous PAS+ autofluorescent granules. In the oligodendrocytes and astrocytes of the white matter these granules appeared electronmicroscopically as cytoplasmic osmiophilic lamellar bodies with fingerprint profile combined with some curvilinear and rectilinear aspects. The cortical nerve cells contained granular osmiophilic bodies. This "leukoencephalopathic" variant of Kufs' disease is probably related to the pigmentary type of orthochromatic leukodystrophy, wherein similar inclusions have been only described in the macrophages and glial cells of the white matter.

Biopsy, Needle↗