Biomedical subjects

M Gjuric

Publications and source records attributed to M Gjuric.

26 records · Page 2Linked to original sources

PubMed1996

Cranial nerve and hearing function after combined-approach surgery for glomus jugulare tumors.

In this retrospective study, oncologic and functional results of 46 patients treated for glomus jugulare tumor are reported. The standard surgical approach was the combined transmastoid-transcervical approach, modified according to the individual tumor growth, and eventually combined with a transtemporal or a suboccipital approach. Complete tumor removal resulted in a cure rate of 90%. New-onset cranial nerve palsies developed in less than 22% of patients. In 54% of cases it was possible to retain middle ear function. From a total of 12 patients with incomplete tumor removal and postoperative irradiation, progressive tumor growth was noted in 4 patients, and was controlled by salvage irradiation or surgery. Radical tumor removal by ablative surgery can be modified by efforts to reduce multilating resections. In their place, individually tailored and combined multidirectional surgical approaches may allow total tumor removal with lower morbidity.

Combined Modality Therapy↗

PubMed1995

Laminin promotes differentiation, adhesion and proliferation of cell cultures derived from human acoustic nerve schwannoma.

The influence of laminin on cell cultures derived from unilateral acoustic nerve schwannomas was investigated. Cell cultures were initiated from 12 schwannomas, removed via the enlarged middle cranial fossa approach. Tumor tissue was dispersed by collagenase treatment and cells seeded in uncoated or laminin-coated culture dishes. Confluent cultures were immunocytochemically characterized with antibodies against S-100, CD 68, factor VIII-related antigen and type IV collagen. Cell adhesion in response to different doses of laminin was evaluated with an electronic cell counter. The effect of laminin on cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxy-uridine (BRDU) into cellular DNA. Cells cultured on laminin as substrate appeared more differentiated with long, fusiform, cytoplasmic processes. Cultured cells stained positive for S-100, not for factor VIII-related antigen or CD 68. Only cells cultured on laminin deposited a dense extracellular network of type IV collagen. When laminin was added to the culture medium, cell attachment and proliferation was stimulated in a dose dependent manner. Maximal stimulation of both was observed with a laminin concentration of 50 micrograms/ml, which induced a nearly 2-fold increase in cell attachment and an approximately 66% increase in DNA content. Since laminin is a major component of the extracellular matrix in schwannomas, the possibility exists that laminin is also mitogenic for human neoplastic Schwann cells in situ.

Adult↗

PubMed1994

Osteoplastic endonasal approach to the maxillary sinus.

A new surgical approach for removal of isolated maxillary sinus pathology, mainly of symptomatic maxillary sinus cysts, is presented. It is based on the principles of osteoplastic sinus surgery and uses the transnasal approach. It allows a safe removal under direct vision or endoscopic control with standard surgical instrumentation. The normal maxillary ostium and healthy ethmoidal cells are not sacrificed and thus the lymphatic pathways as well as the mucociliary transport are not endangered.

Cysts↗

PubMed1993

Comparison of carbon dioxide laser and electrosurgery in the treatment of rhinophyma.

Cosmetic results of rhinophymas treated with carbon dioxide laser or electrosurgery were compared in six patients 2-5 years after surgery. Although the results were comparably good the use of the carbon dioxide laser proved to be more time-consuming and less convenient. Scar formation was observed in both patient groups equally and was related to the depth of tissue removal, independent of the instrument used.

Aged↗

PubMed1992

Selective resection of the semicircular canals of rabbits with preservation of hearing.

The goal of this investigation was to develop a method of surgical removal of the semicircular canals of the rabbit without induction of auditory impairment. Four different surgical techniques were utilized: i) fenestration of the lateral semicircular canal; ii) fibrin glue perfusion of the canal following fenestration; iii) removal of the lateral semicircular canal by drilling after fenestration and fibrin glue perfusion, and iv) removal of all three canals after fenestration and fibrin gluing. Brainstem auditory potentials were recorded repeatedly for up to 3 months after operation and demonstrated preservation of hearing in all rabbits in the first group and in 78% of the second group. In the third group the potentials could be recorded in 67% of the animals and showed a 20 dB deterioration of hearing. After removal of all three semicircular canals residual hearing could be recorded in 50% of the rabbits. These animals regularly showed a 30-40 dB deterioration of hearing. A precise microsurgical technique using fibrin glue and bone chips for interruption of the peri- and endolymph flow proved crucial for hearing preservation.

Animals↗

PubMed1992

[Resection of the semicircular canal system with preserved hearing--an animal experiment study].

In a previous investigation we selectively resected the lateral semicircular canal of the rabbit, preserving the hearing in 67% of the animals. We now report an attempt to remove all three canals in one step with a microsurgical technique using fibrin glue and bone chips. Brain-stem auditory potentials were recorded at intervals up to 3 months after operation. Residual hearing could be recorded in 50% of rabbits. These animals regularly showed a 30-40 dB deterioration of hearing.

Animals↗

PubMed1991

[Selective resection of the lateral semicircular canal with hearing preservation--an animal experiment study].

The goal of our investigation was to develop a method for removing parts of the vestibular labyrinth by surgery without inducing a loss of auditory function. Three different surgical lesions were created in the lateral semicircular canal of the rabbit: (1) fenestration; (2) fibrin glue perfusion of the canal following fenestration; and (3) destruction of the semicircular canal by drilling after fenestration and fibrin glue perfusion. Brain-stem auditory potentials were recorded repeatedly up to 3 months after operation. They demonstrated preservation of hearing in all rabbits in the first group, in 78% of the second and 67% of the third group. In the last group a 20 dB deterioration of hearing was regularly noticed. Histological study revealed the utmost importance of the fibrin glue perfusion of the perilymph space of the semicircular canal inducing an interruption of the peri- and endolymph flow. A precise microsurgical technique was crucial for hearing preservation.

Animals↗

PubMed1990

Microdrill versus perforator for stapedotomy.

The purpose of this study was to compare the hearing results of performing stapedotomy using either a microdrill or a perforator. Two groups of patients, otherwise similar, were followed up for at least 2 years after the stapedotomy. It was possible to create 0.8 mm fenestra in 91.6% of our patients. There was no significant difference between the two groups in hearing results. The results showed a continuous improvement in the first 6 post-operative months after which the hearing stabilized. In our hands, the microdrill has not proved to be more traumatic than the perforator to the inner ear.

Female↗