PubMed Health⌕ Search

Biomedical subjects

M Goldwasser

Publications and source records attributed to M Goldwasser.

3 recordsLinked to original sources

Anatomic studies of the circulation in the region of the vertebral end-plate in adult Greyhound dogs.

In order to study the detailed arrangements of vascular terminations in the region of the vertebral end-plate in adult dogs, infusions of Japanese ink mixed with a suspension of barium sulfate were used to produce filling of the vascular terminations at the vertebral end-plates. Radiographs were made of the decalcified specimens. Photomicrographs were prepared from transparent sections embedded in celloidin. The distribution of the large veins within the vertebral bodies was found to be more complex than described earlier. Over the entire bone-disc interface there is a continuous capillary bed that is most dense in the area related to the nucleus pulposus. These vessels drain either into the subchondral postcapillary venous network or directly into the veins of the marrow spaces in the vertebral bodies.

Animals↗

Analysis of the type of collagen present in osteoarthritic human cartilage.

Abnormal synthesis of type I collagen by fibrocartilage has been suggested as a mechanism involved in degenerative arthritis. Samples of normal and osteoarthritic adult femoral head cartilage were thus studied for histology and collagen composition. The electrophoretic analysis of the cyanogen bromide-derived peptides showed the sole presence of type II collagen in all normal and in all osteoarthritic samples, except those in which fibrocartilage was present. The sensitivity of the technique would not permit, however, the detection of a minute amount (less than 3%) of type I collagen in the samples. The results show that massive deposition of type I collagen occurs only when fibrocartilage is formed. It is suggested that this fibrocartilage is formed when the subchondral bone is damaged.

Aged↗