Biomedical subjects
Publications and source records attributed to M Grellet.
Results of clinical examination are fundamental for establishment of an etiologic diagnosis, but the additional data provided by paraclinical investigations are essential elements. Adenectomy should be performed when etiology is uncertain.
Treatment of temporomandibular ankylosis complicating masseter muscle cellulitis in three patients, as a result of a dental lesion, required wide excision of bone structure and, in two cases, of adjacent infected soft tissues.
Before loco regional treatment for head and neck cancer forty eight patients received one or the other of the following combined chemotherapy regimens: Regimen A (28 patients): high dosage methotrexate, bleomycin, cis-platin; regimen B (20 patients): common dosage methotrexate, bleomycin, hydroxyurea, vincristin. The effectiveness of regimen A seemed better than that of regimen B (46% responses versus 20%). This assessment must be accepted with caution, since, although the organization of treatment was strictly similar in the two groups, the study was not randomized, and there were noticeable differences between the two groups. Regimen B was associated with no toxicity. Regimen A was responsible for two fatalities. These two cases were linked to high dosage methotrexate. However, a combined chemotherapy regimen of type A with the high dosage methotrexate replaced by intermediate dosage methotrexate, seems feasible to us. Loco regional treatment was not impaired by initial chemotherapy with either regimen.
Fourteen years after the discovery of cherubism a young woman presented reconstructive granulomas of the maxilla and mandible. Her grandmother and father had had giant cell mandibular tumors.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The different types of mucopolysaccharidosis, due to a congenital absence of a lysosomial dehydrolysase acid, are the origin of facial deformities. Precise diagnosis depends on the results of biochemical and histological examinations.
Treatment of basal cell epitheliomas of the labial region is essentially surgical excision. Curietherapy appears to be indicated for sclerodermiform epitheliomas, extensive lesions, and when surgery is contra-indicated.
Recent studies relating to soft tissue lesions following irradiation have been concerned with those involving nerves and arteries: Nerve root myelopathies--Brown-sequard's syndrome--spasmodic paraparesis Peripheral neuropathies--plexal disorders--peripheral lesions Carotid stenosis.
Good morphological and functional results are obtained in lateral osteoradionecrosis after bone resection by the endobuccal route, and this operation should be performed at an earlier stage. Median resections give poor results and in these cases it is reasonable to temporize in the normal manner. Long-term prognosis is only moderate as tumoral recurrences are frequent in these patients.
The authors report a case of parotid lithiasis localized to the deep lobe of the gland, which was discovered only after surgical operation.
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This rare condition associates a Pierre Robin syndrome with costal and intellectual abnormalities. It usually rapidly results in death from pulmonary complications.
Tricho-rhino-phalangeal syndrome, of genetic origin, consists invariably of an association of finger malformations, changes in the hair system and nasal malformations. There may also be other facial abnormalities. Plastic surgery may improve the appearance of these subjects.
The prevalence of orbital fractures by blow out remains open to discussion. Operative decisions are taken after clinical and radiological study, being based above all on evaluation of the forced duction tests and upon frontal tomographies.