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Biomedical subjects

M Grigoriu

Publications and source records attributed to M Grigoriu.

11 recordsLinked to original sources
PubMed1995

[Paget's disease of breast--a special form of breast cancer].

The incidence of Paget's disease of the breasts (15 cases) among 701 operated breast cancer was 2.1%. All studied cases were women. Over two-thirds of the patients were at menopause at the time of diagnosis. The interval between the clinical onset of disease and the histological diagnosis was approximately of 21.4 month. The clinical diagnosis was based on the presence of the characteristic erythemato-squamous lesion. In five cases a palpable mass was found. We registered one case of bilateral metachronous Paget's disease. Four patients had axillary lymphadenopathy: three of them presented with palpable mass. Mammography, cytology and histological examination from biopsy were the principal means of diagnosis. There were 10 women in stage, two women in stage II, and three women in stage III. The surgical treatment was the major component of treatment. The best prognosis was registered in the cases without a palpable mass in the breast and axillary lymphadenopathy with 5-year survival in four of five cases.

Biopsy↗
PubMed1994

[The diagnostic and surgical treatment characteristics in gastric ulcer].

The work analyses a number of 283 patients suffering from gastric ulcer, which were hospitalised and operated between 1981-1991. In 64% of cases the surgical treatment decision was an emergency one for major complications of this disease such as: the upper digestive hemorrhage (27%), penetration (22%), perforation (11%), digestive stenosis (4%). In 36% of cases the decision of operation was taken for different reasons: unsatisfactory evolution under the conservatory treatment, the existence of an irreparable anatomic lesion, the recurrent ulcer or the difficulty of differential diagnosis between gastric ulcer and gastric carcinoma. It is important to indicate that the two of the major investigations: the barium transit and the fiber gastroscopy failed in giving a correct relation in 5 to 10% between gastric ulcer and gastric carcinoma. In 87% of patients it was performed the gastric resection type Péan. The lifting of the lesion in 7% of our observations needed the gastric resection on type Pochet. In the gastric ulcers Johnson II type, when the duodenal lesion couldn't be lifted we added to the Hoffmeister-Finsterer gastric resection type with truncal vagotomy. In 9% of patients with perforated or hemorrhagic gastric ulcer, the vital rise was a major one, so we performed only suture the lesion. We registered 3 deaths (1.06%).

Adult↗
PubMed1991

[The diagnosis and therapeutic approach in acute necrotic-hemorrhagic pancreatitis].

The work contains the clinical and therapeutic analysis of a group of 72 patients with acute necrotic-haemorrhagic pancreatitis (ANHP), admitted in the period 1979-1989 to the Ist Surgical Clinic of the Municipal Clinical Hospital of Bucharest. The etiology of ANHP, its clinical forms of manifestation, the peculiarities of shock and its dynamic course are shown and discussed. Stress is laid on the criteria of severity, on the course and on the complications occurred. The therapeutic results are commented in detail and the mortality is studied in a complex way, by analysing both the terminal clinical manifestations and the results of anatomicopathological examinations.

Acute Disease↗
PubMedDate not supplied

Renin and aldosterone reactions after acute hemorrhage.

Among the pressor homeostatic mechanisms that appear after hemorrhage are renin-angiotensin response and aldosterone hypersecretion. Plasma renin activity (PRA) may decrease initially but increase always after a certain interval. Aldosterone secretion increases or decreases in a higher or lower degree. It is generally accepted that Ang II is one of the principal factors that stimulates aldosterone secretion, but from our material it resulted that after hemorrhage it evolves independently. This discrepancy is more evident if hemorrhage is followed by bilateral nephrectomy (BN), when PRA significantly decreases but aldosterone secretion increases. After a simple BN, PRA decreases significantly but aldosterone plasma concentration increases, a discrepancy that is more evident if BN are followed by hemorrhage. Thus, it appears that after hemorrhage, the aldosterone secretion is not stimulated by the renin-angiotensin system.

Acute Disease↗
PubMedDate not supplied

[Breast cancer in men].

In 20 years we registered 10 observations of male breast cancer (MBC), representing 1.3% out of 767 patients with breast cancer. Two observations of gynecomastia have been noted as a possible risk factor for MBC. A tumoral mass behind the areola suggested the diagnosis in 9 patients, whether in one case the attention was drawn by a bloody nipple discharge. In 3 cases we noted local aggravation clinical signs, and 6 observations presented homolateral palpable adenopathy. Diagnosis was completed by radiology, scintigraphy and pathology. As for clinical staging, we had 1 case in stage I,3 patients in stage II, 5 in stage III and I case in stage IV. Surgical treatment was the major therapeutical mean of the complex oncological procedure. We performed radical mastectomy in 4 cases. MBC prognosis was poor. Only one patient of the 6 ones in stage III and IV survived to five years; among other 4 observations in stage I and II, 2 patients have survived to five years, and other 2 being followed-up through the oncological network.

Aged↗
PubMedDate not supplied

[Difficult laparoscopic cholecystectomy].

The study analyses different situations encountered throughout the authors personal operative experience, susceptible to generate technical and tactical difficulties during laparoscopic cholecystectomy such as: postoperative perivisceritis, obesity, difficult liver mobilization, lipomatosis, acute and scleroatrophic cholecystitis, "porcelain gallbladder". They also point out different causes capable of generating important bleeding during the operation: cirrhosis, accidental adhesion tearing, anatomical arterial variations. Above all, the study presents the possible technical and tactical solutions which they applied when dealing with the already mentioned critical situations.

Acute Disease↗
PubMedDate not supplied

[Treatment with Ginkor Fort in varicose veins].

The study shows the experience acquired in our clinic concerning Ginkor fort administration in varicose veins pathology. The research comprises 32 patients who were treated by the well-known classical procedures (hygienic-dietetic, contention, surgery) and by Ginkor fort administration. The study rendered 71% good results consisting in evident amelioration of symptomatology, both subjective and objective.

Adult↗