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M Grigoroiu-Serbănescu

Publications and source records attributed to M Grigoroiu-Serbănescu.

13 recordsLinked to original sources
PubMed1991

Adolescent offspring of endogenous unipolar depressive parents and of normal parents.

Ninety-six children aged 10-17 of unipolar endogenous depressive proband parents and 96 matched control children of well parents were investigated using DSM-IIIR diagnostic criteria. Both sets of parents were also studied. Although the rate of psychopathology was significantly higher in proband than in control children, adaptive functioning as a measure of the severity of the psychopathology did not differentiate the two groups of children. Among factors related to the mental status of the children were: severity and onset under 30 years of age of the parental depression and lifelong association of parental anxiety with depression. Personality measurements performed in children showed different personality structures in proband offspring. Data on adolescent psychopathology and personality showed little evidence of a homotypic relationship with the adult affective disorders.

Adolescent↗
PubMedDate not supplied

Psychopathology in children aged 10-17 of bipolar parents: psychopathology rate and correlates of the severity of the psychopathology.

Seventy-two proband children aged 10-17 of bipolar parents, matched with 72 control children of normal parents, were investigated using DSM-III diagnostic criteria and multiple sources of information. The psychopathology rate in children (61% in probands versus 25% in controls) was related to the impact of psychic disorders on the children's adaptive functioning. The effect of several variables describing the psychiatric status of both parents and familial environment on the severity of psychopathology in children was analysed. Disordered and non-disordered probands were compared with respect to illness characteristics of their parents, familial environment, personality traits, and IQ by means of canonical discriminant analysis.

Adolescent↗
PubMedDate not supplied

A trial to apply the concept of genomic imprinting to the manic-depressive illness.

The phenotypic indicators of genomic imprinting were applied to the familial psychopathology data collected through the family history method about 886 adult relatives of 65 manic-depressive probands directly investigated. The probands and their relatives were diagnosed according to DSM-III/DSM-III-R criteria. A first analysis of the age at onset of the BP illness by affective status of the probands' parents suggested that the BP disorder begins about 8 years earlier in the probands whose father was affectively ill (13.84% cases) than in the probands whose mother was affectively ill (24.6% cases) (t = -3.29, P < .004). When controlling this result for the effect of the probands' sex, its statistical significance decreased. The severity of the BP illness seemed also to be influenced by the affective status of the probands' father but only when assessing the probands' illness severity over a long time period and taking into account their psychosocial functioning; the number of manic and depressive hospitalized and non-hospitalized episodes as a single measure of the BP disorder severity as well as the morbidity risk in the first degree relatives of the probands did not significantly differentiate the patients whose disorder was transmitted by the father/paternal side as compared with the patients who inherited the BP disorder from the mother/maternal side.

Adolescent↗
PubMedDate not supplied

Children aged 10-17 of endogenous unipolar depressive parents and of normal parents. I. Psychopathology rate and relationship of the severity of the psychopathology to familial and environmental variables.

Seventy two children aged 10-17 of 42 endogenous unipolar depressive parents (proband children) and 72 children aged 10-17 of 66 normal parental couples (control children) were studied. Overall rate of psychopathology (disorders present at the time of investigation and one year before) reached 51% in proband children and 29% in control children. Depressive disorder rate reached 10% in proband children and 4% in control children. The sex of the depressive parent did not influence the psychopathology rate in offspring, while the early age of onset of the illness (under 30 years) in parent increased the psychopathology risk in children. The severity of the psychopathology in children defined as functional impairment was significantly dependent on the severity of the depressive illness in proband parent, the presence of psychopathology in the spouse of the depressive parent, the presence of psychopathology in the relatives of both parents, the socio-cultural level of the family and the violence expressed in the familial atmosphere.

Adolescent↗
PubMedDate not supplied

A rating scale for the severity of psychopathology in children.

The Scale for Assessing Severity of the Psychopathology in Children (SSPC) is intended to measure the overall psychosocial impairment caused to children and adolescents by psychic disorders. The scale contains 3 items (number of impaired areas of psychosocial functioning and duration of the modifications of child's behaviour; decrease of school performances below the expected level according to IQ; subjective distress caused by the psychic disorder either to the child or to the family leading to call for medical help) defining a single dimension. Each item is scaled on four degrees of impairment and described behaviourally in a detailed way. The total score summed over the 3 items corresponds to four levels of severity of the psychopathology. Interrater reliability, sensitivity to change and concurrent validity of the SSPC are examined over three studies.

Adaptation, Psychological↗