Biomedical subjects

M Grisanti

Publications and source records attributed to M Grisanti.

11 recordsLinked to original sources

PubMed1991

[Severe ischemia of the hand. Treatment with regional intravenous sympathicolysis with reserpine].

Treatment of severe hand ischemia a associated to progressive systemic sclerosis and other disorders is controversial. We studied prospectively 45 patients, 41 female and 4 males, over an 11 year period. Age ranged from 16 to 73 years, mean 46. Underlying disease was systemic sclerosis in 30, CREST in 8, overlapping syndrome in 4, systemic lupus in 1 and non rheumatic vasculitis in 2 patients. Treatment consisted of intravenous injection of reserpine, 1 mg, at a superficial arm vein after controlled local circulatory block for 15 min. Regional anesthesia was required in 38 patients. Adequate follow up was obtained in 32 females and 2 males, receiving a mean of 3.1 therapy sessions (range 1 to 13). Morphologic improvement from 3.09 +/- 0.16 to 1.57 +/- 0.13 and functional improvement from 3.6 +/- 0.12 to 1.75 +/- 0.14 (5 grade scoring system), was observed (p < 0.001). These results correlate with adequate rehabilitation confirmed clinically.

Adolescent↗

PubMed1991

[Methotrexate in rheumatoid arthritis].

Methotrexate may be effective in patients with rheumatoid arthritis refractory to other treatments (gold salts, d-penicillamine and antimalarial drugs). Success rates from 39 to 88% have been reported. The mechanism of action is unknown, but is supposedly related to anti-inflammatory and immunosuppressive effects. Frequent side effects are observed on prolonged treatment. Most of these are mild and disappear with dose reduction. An exception is pneumonitis, a hypersensitivity reaction that may appear early and at low doses. Hepatotoxic effects are milder than those observed in patients with psoriasis. Intraarticular administration is not effective. No carcinogenic effects have been observed in humans. The drug should be administered with caution in fertile males and females due to possible teratogenic effects. New studies involving larger number of patients may help establish a significant role for methotrexate in the treatment of rheumatoid arthritis.

Arthritis, Rheumatoid↗

PubMed1990

[Thyroid disease in progressive systemic sclerosis].

There is no agreement wither thyroid disease is a common feature of progressive systemic sclerosis (PSS). We evaluated 28 patients with proven PSS with determinations of T3, T4, TSH and Tg as well as antimicrosomal autoantibodies. Radioactive I uptake, thyroid scintigraphy, TRH test and fine needle biopsy were performed in selected patients. Twelve (43%) patients had clinical or laboratory evidence of thyroid dysfunction. Four patients had euthyroid goiter, 3 had evidence of autoimmune disease, 2 had chronic Hashimoto's thyroiditis, 1 was hypothyroid, 1 hyperthyroid and one has subacute thyroiditis. The CREST variant of PSS was most commonly associated with thyroid pathology. Our results indicated that thyroid disease is frequently associated to PSS. A complete clinical and laboratory evaluation is needed to confirm its presence.

Adult↗

PubMed1988