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Biomedical subjects

M Grochowicki

Publications and source records attributed to M Grochowicki.

14 recordsLinked to original sources
PubMed1991

Homonymous horizontal sectoranopia: report of four cases.

Four cases of right homonymous horizontal sectoranopia are described. They were investigated with automatic static perimetry matched in three cases with Goldmann perimetry. In two cases--a wound of lateral sinus, a temporal surgically excised oligo-dendroglioma--neuroradiological investigations localised the visual pathways lesion to the optic radiations. In two other cases the lesions of vascular origin were less precise. In both of these there were ischaemic phenomena. In one of them the left anterior superficial sylvian territory was involved and in the other the left anterior choroidal artery territory was in question. This visual field pattern, less rare than was previously supposed, seems in some cases to correspond to retrogeniculate and varied topographic lesions.

Adult↗
PubMed1991

Pituitary adenomas: automatic static perimetry and Goldmann perimetry. A comparative study of 345 visual field charts.

In a series of 81 cases of pituitary adenoma 345 charts of visual field performed with static automatic perimetry (AP) on the Vision Monitor and Goldmann perimetry (GP) were compared. Generally both methods were equivalent in the detection of chiasmal compression. The charts were divided into two groups: (A) 208 charts and (B) 137 charts according to the number of isoptres investigated: two (V4, 112) or three (V4, 112, 12). In group A the AP was more often altered than the GP, and the difference was statistically significant (p less than 0.001). In group B the GP seemed more effective, but the number of questionable cases was greater and the difference was not statistically significant. When the most internal isoptre of GP was outside the central 30 degrees, AP was more often abnormal (29%) than GP (2.2%), and the difference was statistically significant (chi 2, p less than 0.001). Within the central 30 degrees the GP seemed more often to be altered (23% of cases) than the AP (19.4%), but one-third of the cases were questionable. Within the central 30 degrees both techniques gave identical results and there was no statistically significant difference. The discrepancies between both static and kinetic techniques are an argument for their complementary use.

Adenoma↗
PubMed1990

Effects of a new prolactin inhibitor, CV 205-502, in the treatment of human macroprolactinomas.

The effects of a new PRL inhibitor, CV 205-502 (CV), on human macroprolactinomas were studied in nine patients according to a prospective protocol. Five patients had undergone surgery leaving tumor remnants and persistent hyperprolactinemia. The four others were de novo patients, two of whom had received short term treatment with Parlodel. Plasma PRL levels ranged from 235-6050 micrograms/L before treatment. The doses of CV used in this trial ranged from 0.075-0.600 mg. Plasma PRL normalized in eight of the nine patients during treatment with CV. The time to normalize varied from 2 weeks to 9 months, and the doses from 0.075-0.450 mg. A tumor volume reduction of more than 50% was obtained in all four patients who had not been operated on before CV treatment. Only one of the five patients with postoperative tumor remnants had no reduction in tumor size. The drug was generally well tolerated, and no patient interrupted the treatment. Slight and short-lasting gastrointestinal symptoms were noted in several patients, and a single episode of fainting occurred in one patient when the drug was not taken at bedtime as instructed. A noticeable and persistent weight loss with anorexia was noted in two patients. Since CV 205-502, administered in a single daily dose, has tolerable side-effects and is effective in reducing PRL secretion and tumor size, it can be considered to be a useful treatment for macroprolactinomas.

Adult↗
PubMed1990

[Spatial contrast sensitivity in multiple sclerosis].

Spatial contrast sensitivity was measured in 110 patients with multiple sclerosis (definite = 72, probable = 22, possible = 16) as part of a routine evaluation in a neuro-ophthalmological clinic. Results were compared with those of 37 normal controls matched for age. The test was abnormal in 71 p. 100 of patients. Contrast sensitivity was attenuated for 97 p. 100 of the eyes with optic neuritis and visual acuity drop, for 60 p. 100 of the eyes with recovered optic neuritis and for 36 p. 100 of the non affected eyes in the cases of unilateral optic neuritis. Among the 57 patients with normal visual acuity and no history of optic neuritis, 62 p. 100 had abnormal findings. Globally, contrast sensitivity was reduced on the whole spatial frequency range in cases of current optic neuritis, and mostly on the high or high and medium frequencies in the other cases. Our study confirms that spatial contrast sensitivity is the most sensitive of psychophysical methods to detect subclinical visual impairement in multiple sclerosis. Comparison with VEP's was performed in 66 patients. Both tests were roughly equally sensitive, but findings were concordant in only 63 p. 100 of the cases. The use of both VEP's and spatial contrast sensitivity increases the detection of latent optic neuritis.

Acute Disease↗
PubMed1988

[Evaluation of the central visual field by the Friedmann Mark I analyzer and color vision in 85 patients with multiple sclerosis. Correlation with visual evoked potentials in 50 cases].

Analysis of the visual field using Friedmann's analyser Mark I and color study in 85 multiple sclerosis patients. Static perimetry of the central visual field and test batteries (Ishihara plates, 15 Hue Standard, 15 Hue of Lanthony) for acquired color vision defects were performed in 85 multiple sclerosis patients (61 definite, 12 probable, 12 possible cases). Results in patients were compared to data obtained in 53 control subjects matched for age. 64% of the 85 patients and 52% of 48 patients with no history of optic nevritis showed visual field abnormalities and/or color vision defects. Comparison with VEP was available in 50 patients. While 10 patients had abnormal VEP and normal static perimetry and coloration tests, 5 patients had the reverse findings.

Adolescent↗