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Biomedical subjects

M Guibert

Publications and source records attributed to M Guibert.

At least 19 recordsLinked to original sources
PubMed1991

[Value and limits of research on Mycoplasma hominis and Ureaplasma urealyticum in the gastric fluid of newborn infants].

Mycoplasma hominis and Ureaplasma urealyticum were cultured and counted in the gastric fluid of 153 neonates divided into three groups: 28 preterm neonates managed in an intensive care unit (Group I); 83 full term neonates with suspected infection (Group II); and 42 full term neonates with no evidence of infection (Group III). The colonization rate (17.85%) in the intensive care unit group was not significantly different from the rates seen in the two other groups. These results do not militate against the pathogenic role of the two organisms studied but rather suggest a contributory role of other factors.

Colony Count, Microbial↗
PubMed1991

[Value and limitations of the research of Mycoplasma hominis and Ureaplasma urealyticum in gastric fluid in newborn infants].

Mycoplasma hominis and Ureaplasma urealyticum were cultured and counted in the gastric fluid of 153 neonates divided into three groups: 28 preterm neonates managed in an intensive care unit (Group I); 83 full term neonates with suspected infection (Group II); and 42 full term neonates with not evidence of infection (Group III). The colonization rate (17.85%) in the intensive care unit group was not significantly different from the rates seem in the two other groups. These results do not militate against the pathogenic role of the two organisms studied but rather suggest a contributory role of other factors.

Gastric Juice↗
PubMed1987

[Comparative pharmacokinetics of fosfomycin in the neonate: 2 modes of administration].

In newborn, fosfomycin-cefotaxime in combination is more and more commonly used for the treatment of nosocomial infections. A pharmacokinetic study was conducted in ten newborns in the aim of suggesting a therapeutic schedule of the fosfomycin. Each newborn received 200 mg/kg, intravenously twice a day. Two groups have been formed according to the time of perfusion: 2 h or 30 min. The study of pharmacokinetic parameters do not demonstrated significant difference between the two populations. In addition, residual serum concentrations, twelve hours after the administration, are greater than the minimal inhibitory concentrations of most common pathogens causing nosocomial infections in neonates.

Age Factors↗
PubMed1987

[Intravenous-intramuscular bioequivalency of ceftriaxone in newborn infants].

In 6 neonates over 7 days of life, comparison of maximum and residual serum concentrations of ceftriaxone after intra-venous or intra-muscular administration showed the bio-equivalence of both ways. In both cases a single daily injection obtained bacterial serum levels on most of the strains responsible for secondary bacterial infections in neonates.

Biological Availability↗
PubMed1986

Human Fc(gamma) receptors for differentiation in throat cultures of group C "Streptococcus equisimilis" and group C "Streptococcus milleri".

The biochemical characteristics and the presence of human Fc(gamma) receptors of 52 throat isolates of group C beta-hemolytic streptococci were examined. Among these isolates, 38 were identified as "Streptococcus milleri" and 14 were identified as "Streptococcus equisimilis." The differentiation of group C "S. equisimilis" from "S. milleri" with identical group antigens was easy to perform by the measurement of the size of the hemolytic zone on a sheep blood agar plate in an anaerobic atmosphere and by biochemical tests (Voges-Proskauer test). A clear-cut criterion for differentiation was noted among these isolates, i.e., the presence of Fc(gamma) receptors. "S. equisimilis," which are generally associated with pharyngitis, possess human Fc(gamma) receptors, while "S. milleri", which are generally isolated from healthy persons, have no such receptors.

Humans↗
PubMed1986

[Failure of anti-pneumococcal vaccination and prophylactic antibiotic therapy in 2 splenectomized subjects].

Asplenic patients are at high risk for the development of fulminant pneumococcal bacteremia. The mortality rate in those infected patients remains high. Therefore pneumococcal polysaccharide vaccine has been recommended, but despite penicillin prophylaxis pneumococcal sepsis can occur in vaccinated patients. We have observed two cases (one fatal) of overwhelming postsplenectomy pneumococcal sepsis in vaccinated patients who received long-term antibiotic prophylaxis. Both exhibited a poor antibody response to polyvalent vaccine.

Adult↗
PubMed1985

[Technic for detecting several yeasts in the same sample].

The frequent association of Torulopsis glabrata with other yeasts of the genus Candida in the same clinical specimen may lead to false results because of the large number of negative characters in this yeast. We describe here a technique of detection based on the pigmentation of colonies obtained by reduction of triphenyl-tetrazolium chloride added to the Sabouraud medium.

Aged↗
PubMed1980

[Indirect and direct indicators of pulp repair of human homografts. Preliminary studies of histoclinical correlation (author's transl)].

A clinical experimental study involving human grafts (heterochronic and heterogenic homografts) was carried out after different techniques (isolation, preservation, decontamination, freezing-thawing cycles of grafts). Surgical application then the clinical and radiological course were followed up over a period of up to 4 years. Some pulp specimens were examined histologically. Clinical, radiological and histological correlation was envisaged in order to offer hypotheses, in particular immunological, with regard to the course of the process.

Dental Pulp↗
PubMedDate not supplied

Suspected postpartum endometritis: a controlled clinical trial of single-agent antibiotic therapy with Amox-CA (Augmentin) vs. ampicillin-metronidazole +/- aminoglycoside.

Endometritis is the commonest postpartum complication and is one of the leading causes of maternal morbidity, if not mortality. The object of the present clinical trial was to assess the efficiency of single-agent therapy with Amox-CA (Augmentin) (formulation which includes a beta-lactamase inhibitor), against standard treatment which necessarily combines two or three antibiotics depending on the clinical severity of the case. 101 patients were evaluated in this comparative prospective randomized study. The mild forms were defined by a temperature between 37.9 and 38.4 degrees C and the severe forms by a temperature of more than 38.5 degrees C (which alone required treatment with three antibiotics). The time until the return of apyrexia and the clinical cure rate, as well as duration of treatment, were identical in both groups. Tolerance was good: no side effect requiring discontinuation of treatment occurred. In the population value, the use of a single-agent therapy with amoxycillin/clavulanic acid is not significantly different from a double or triple-agent regimen, and the convenience is increase.

Adult↗
PubMedDate not supplied

Recurrent enterocolitis-like symptoms as the possible presenting manifestations of neonatal Brucella melitensis infection.

A premature infant had three episodes of enterocolitis-like symptoms during the first three months of life. Brucella melitensis was isolated in a prolonged blood culture on day 85. The clinical manifestations disappeared under treatment and did not recur. A maternofetal transmission is suggested in this case. The importance of prolonged blood cultures when brucellosis is epidemiologically suspected is emphasized.

Adult↗