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Biomedical subjects

M Gummerus

Publications and source records attributed to M Gummerus.

27 records · Page 2Linked to original sources

[Treatment of premature labour and antagonization of the side effects of tocolytic therapy with verapamil (author's transl)].

167 cases of threatened premature birth were treated with Fenoterol, Fenoterol + Verapamil and Ritodrine. In 70-79% of cases a newborn of over 2500 g was achieved. In 70-76% it was possible to prolong the pregnancy for over 7 days and in 61-64% a gestation age of 37 weeks and more was reached. Special attention was paid to the facts as to whether the general side effects of Fenoterol can be antagonized with Verapamil.

Abortion, Threatened

Treatment of imminent premature labour.

In this study, 194 imminent premature deliveries were treated. The pregnancies were in the 28th to 36th week. Uterine contractions were demonstrable in all patients and amniotic membranes were intact. All patients were treated with bedrest. Two betasympathomimetics were used in a double-blind study: Nyldrin hydrochloride (43 cases) and Isoxuprine hydrochloride (60 cases). A placebo was given to 41 patients, and ethyl alcohol to 50 patients. Intravenous and intramuscular treatment given in the hospital was continued with oral administration at home, and follow-up examinations were repeated at short intervals. Taking a minimum birth weight of 2500 g as the criteria of successful treatment, the success rate in the placebo group was 71%, in the Nylidrin hydrochloride group 86%, the Isoxuprine hydrochloride group 75% and the alcohol group 70%. When premature delivery was postponed 7 days, the pregnancy advanced., to the 37th week or later in 73, 77, 62 and 56% in their respective groups. The beta-sympathomimetics, especially the Nylidrin hydrochloride, were in every respect more efficient than placebo or alcohol. The therapeutic effect of alcohol was no better than that obtained with placebo. From the fetal point of view, the drugs used in the present study showed no adverse-effects.

Birth Weight

[Prevention of premature birth with nylidrin and verapamil (author's transl)].

108 cases of threatened premature birth were treated with i.v. drip-infusion, followed by oral treatment with Dilatol and Isoptin. This was successful in 81% of cases. A birth-weight of over 2500 g was considered a positive result. In 14% of cases there were side effects. The results are compared with earlier investigations.

Birth Weight

[Effect of socioeconomic factors on twin pregnancy].

A material of 336 mothers of twins was divided into four groups on the basis of socioeconomic background. On average, mothers belonging to the first social class delivered at 38.2 +/- 1.6 week of pregnancy and their newborn weighed more than those in other social classes. Careful follow-up at outpatient maternity clinics is warranted in the case of expectant mothers of twins belonging to the third or fourth social class.

Adolescent