Biomedical subjects

M Guttinger

Publications and source records attributed to M Guttinger.

21 records · Page 2Linked to original sources

PubMed1986

Stimulation of the antibody response after treatment with thymomodulin in mice immunodepressed with cyclophosphamide and in aging mice.

The capacity of Thymomodulin, a thymic derivative, to restore the antibody response and the number of circulating leucocytes in immunodepressed animals was studied. Administered daily to cyclophosphamide-treated mice, Thymomodulin significantly stimulated the recovery of the antibody response to sheep erythrocytes after a second administration of the antigen. The white blood cell count also showed a rapid and significant increase. Antibody titres were enhanced to normal range values again in immunodepressed rabbits. The possible mechanism of these findings is discussed. Some preliminary results obtained in restoring the immune response in aged mice are also reported.

Aging↗

PubMed1985

Immunopathology of the eye: purification of canine retinal "S" antigen.

Canine retinal S antigen has been purified to study the retinal progressive atrophy of the dog. The purified antigen will be used to detect, by the ELISA technique, specific autoantibody in dogs with ocular diseases.

Animals↗

PubMedDate not supplied

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules.

An ideal vaccine should elicit a long lasting immune response against the natural parasite, both at the T- and B-cell level. The immune response should occur in all individuals and be directed against determinants that do not vary in the natural parasite population. A major problem in designing synthetic peptide vaccines is that T cells generally recognize peptide antigens only in association with one or a few of the many variants of major histocompatibility complex (MHC) antigens. During the characterization of epitopes of the malaria parasite Plasmodium falciparum that are recognized by human T cells, we analysed a sequence of the circumsporozoite protein, and found that synthetic peptides corresponding to this sequence are recognized by T cells in association with many different MHC class II molecules, both in mouse and in man. This region of the circumsporozoite protein is invariant in different parasite isolates. Peptides derived from this region should be capable of inducing T-cell responses in individuals of most HLA-DR types, and may represent good candidates for inclusion in an effective anti-malaria peptide vaccine.

Amino Acid Sequence↗