Tuberous sclerosis.
The strong relationship between tuberous sclerosis, cardiac rhabdomyoma, and angiomyolipoma of the kidney is well illustrated in this family case study.
Adult↗
Biomedical subjects
M H Dawson
Publications and source records attributed to M H Dawson.
Simultaneous combined anterior and posterior fusion. A surgical solution for failed spinal surgery with a brief review of the first 150 patients.
Simultaneous combined anterior and posterior fusion (SCAPF) is recommended for patients with severe disability and failed spinal operations. In 150 patients treated over the past five years, emphasis is placed on the evolution of the technique and the surgical principles that exclude decompression of the nerve roots. The available evidence suggests that 86% of the patients were improved; 60% were significantly improved.
Adolescent↗
II. Disease and social change. Smallpox in Kenya, 1880-1920.
Explore the source record for details and available documents.
History, 19th Century↗
Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.
In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.
Administration, Oral↗
Turnover of collagen in the adult rat after denervation.
Unilateral denervation of the hind limb in a group of adult rats prelabeled with radioactive proline induced a significant turnover of collagen in tendons, ligaments, menisci, and bones. After two or three months of disuse, there were significant losses (15 to 29 per cent) of old collagen from the four structures studied. Dilution of the radioactivity of the old collagen with new collagen involved partial to complete replacement of 3 to 20 per cent. The incomplete replacement of destroyed collagen with new collagen resulted in a net decrease of collagen mass ranging from 5 to 14 per cent. A significant turnover of collagen in two-year-old rats that showed little loss in collagen mass means that the new collagen produced would have fewer cross-links and would probably be weaker than the old, mature collagen.
Animals↗