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Biomedical subjects

M H Ellestad

Publications and source records attributed to M H Ellestad.

At least 19 recordsLinked to original sources
PubMed1992

Analysis of the signal-averaged P-wave duration in patients with percutaneous coronary angioplasty-induced myocardial ischemia.

To assess the impact of angioplasty-induced myocardial ischemia on the duration of the surface P wave, patients undergoing elective angioplasty of isolated lesion in the left anterior descending, circumflex or right coronary arteries were monitored with a 3-channel electrocardiographic Holter system. The leads used were modified bipolar chest leads V5, aVF and V2 (CM-V5, CS-aVF and CM-V2). After echocardiographic signal-averaging, the earliest onset and the latest offset of the P wave were identified in all of the above time-aligned signal-averaged leads, and the composite maximal P duration was measured under 10 x magnification. The maximal ST-segment shift during balloon inflation was also measured in all of the above leads at 60 ms after the J point. In the study group comprising 47 patients, the mean signal-averaged P-wave duration was 125.0 +/- 16 ms at baseline versus 130.0 +/- 15 ms during balloon inflation, p less than 0.005. In the left anterior descending coronary artery group (n = 23), the mean signal-averaged P-wave duration was 122.4 +/- 17 ms and 131.3 +/- 16 ms during balloon inflation, p less than 0.005). In the group with a right coronary artery lesion (n = 18), the values were 127.3 +/- 14 ms and 128.4 +/- 13 ms respectively (p = not significant). Significant increases in the P-wave duration were found to occur in groups both with (n = 34) and without (n = 13) ST-segment shift greater than or equal to 1 mm (both p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Algorithms↗
PubMed1992

Efficacy of three-channel ambulatory electrocardiographic monitoring for the detection of myocardial ischemia.

The recognition of silent myocardial ischemia (SMI) has been demonstrated to have important clinical relevance. Two-channel ambulatory (Holter) electrocardiographic recording is a commonly utilized method for detecting transient electrocardiographic ST segment changes representative of SMI. It has been suggested that the analysis of two channels alone may not adequately detect SMI. We therefore evaluated the diagnostic yield of three channels using a three-channel electrocardiographic monitoring device in 46 consecutive patients (age 61 +/- 9 years) undergoing percutaneous transluminal coronary angioplasty of an isolated single-vessel stenosis. Modified bipolar chest leads V2, V5, and AVF (CM-V2, CM-V5, and CS-AVF) were utilized for analysis. The percent detection of ST segment changes from various combinations of two-lead recordings were compared to the total three leads, and an absolute transient ST segment shift (STSS) of greater than or equal to 1 mm during balloon inflation was considered as evidence of myocardial ischemia. One patient was excluded because of the need for ventricular pacing during balloon inflation. A total of 33 of 45 patients had STSS in all three leads (percent detection = 73%), while 32 (71%) had STSS in the two-lead grouping with the highest diagnostic yield (CM-V2/CM-V5; p = ns). Of the various two-lead combinations studied, leads CM-V2 and CM-V5 provided the best lead set overall for the detection of ischemic STSS. Three-channel ambulatory electrocardiographic recording only marginally improves upon the detection of ischemia when compared with standard (CM-V2/CM-V5 or CM-V5/CS-AVF) two-channel ambulatory electrocardiographic recordings.

Angioplasty, Balloon, Coronary↗
PubMed1992

The predictive value of the time course of ST segment depression during exercise testing in patients referred for coronary angiograms.

We studied the time course of ST segment depression during and after exercise testing in 462 subjects who also had coronary angiograms. Sixty-three percent of patients with late onset-early offset ST depression, previously reported to be likely to have false positive tests, had significant coronary artery disease, and 32% had three-vessel disease. Those with early onset and late offset ST depression and those with resting ST depression that was accentuated with exercise had a high prevalence of significant coronary artery disease and three-vessel disease. We found that observation of the time course of ST depression during and after exercise adds significantly to the information gained during exercise testing.

Aged↗
PubMed1992

Computer probability estimates of angiographic coronary artery disease: transportability and comparison with cardiologists' estimates.

A computer algorithm for estimating probabilities of any significant coronary obstruction and triple vessel/left main obstructions was derived, validated, and compared with the assessments of cardiac clinician angiographers. The algorithm performed at least as well as the clinicians when the latter knew the identity of the patients whose angiograms they had decided to perform. The clinicians were more accurate when they did not know the identity of the subjects but worked from tabulated objective data. Referral and value induced bias may affect physician judgment in assessing disease probability. Application of computer aids or consultation with cardiologists not directly involved with patient management may assist in more rational assessments and decision making.

Adult↗
PubMed1992

The significance of lead strength on ST changes during treadmill stress tests.

The contribution of relative lead strengths to ST depression during exercise was evaluated in 334 patients who had both a treadmill stress test and an angiogram. Patients were referred for exercise testing for the evaluation of suspected or known coronary artery disease. This was accomplished by comparing the magnitude of ST-segment depression to a constructed ST/R ratio. Using a cutoff of 0.1 for the ST/R ratio, the data were compared to the sensitivity and specificity of the 1 mm criteria for ST depression. There was only a slight increase in sensitivity (59% vs 63%) and specificity (60% vs 78%) for the ST/R ratio in comparison to the standard ST depression. However, when these two criteria were reevaluated for patients with less than or equal to 10.0 mm of R wave amplitude, the 0.1 ST/R ratio had a small decrease in specificity (94% vs 80%) when compared to 1 mm of ST depression and a marked increase in sensitivity with 31% for the standard ST depression and 82% using the ST/R ratio. In those with an R wave greater than 20 mm, 1 mm of ST depression was much more sensitive than the ST/HR ratio (95% vs 59%), but the ratio was more specific than the conventional ST depression (78% vs 59%). It is concluded that ST depression should be corrected for R wave amplitude in patients with R waves less than 10 mm and over 20 mm.

Coronary Angiography↗
PubMed1991

Significance of signal-averaged P-wave changes during exercise in patients with coronary artery disease and correlation with angiographic findings.

The maximal P-wave duration in all time-aligned leads, and the maximal P-wave amplitude in leads V5 and V6 were measured on a 12-lead, signal-averaged electrocardiogram during the recovery period of an exercise stress test (EST). The study group consisted of 75 patients with coronary artery disease (CAD) documented by greater than or equal to 50% diameter stenosis in 1 or more arteries and a control group of 47 subjects, 15 of them young volunteers and 32 with no or minimal coronary atherosclerosis and normal left ventricular function. All subjects underwent a symptom limited EST, with use of the Ellestad protocol. Signal-averaged P waves recorded before exercise, and for the first 6 minutes in recovery were measured using a 5x magnifier. The mean P duration before exercise in the control group was 107 +/- 16 ms (+/- 1 standard deviation) and 111 +/- 15 ms at the third minute of recovery, (p less than 0.001). In patients with CAD it was 112 +/- 12 and 129 +/- 19 ms (+/- 1 standard deviation), p less than 0.001, respectively. Differences in P-wave duration were found to be statistically significant (p less than 0.001) throughout recovery in the group with CAD when compared with control and maximal values at the third minute. The increase in P-wave duration (greater than or equal to 20 ms) was used as an additional parameter to exercise-induced ST-segment depression, ST elevation, or anginal pain for the test interpretation. The sensitivity increased from 57 to 75% and the specificity decreased from 85 to 77%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Dacron-woven pacemaker pouch. Influence on long-term pacemaker mobility.

Pacemaker migration can interfere with correct pacing system function and patient comfort. A Dacron pouch has been developed which may prevent these problems. To assess the efficacy of the pouch, we measured various factors of pacemaker mobility in 100 patients after long-term follow-up. The patients were divided into three groups on the basis of their dictated operative reports: group 1, no pouch or anchoring stitch; group 2, pouch only; group 3, anchoring stitch to pacemaker header or pouch. The average age of the study population was 74.3 +/- 11 years. Total follow-up time was 42 +/- 28 months (group I, 53 +/- 32 months; group 2, 36 +/- 23 months; group 3, 34 +/- 25 months). There were no significant differences when pacemakers were measured for movement in the inferosuperior and lateromedial directions, nor was there any difference in the distance between the incision scar and the pacemaker header in any group. There was a significant difference between group 1 and groups 2 and 3 when the degree of tilt of the pacemaker off the chest wall was compared. This was 46 degrees +/- 34 degrees for group 1 and 27 degrees +/- 26 degrees and 26 degrees +/- 27 degrees for groups 2 and 3, respectively (p less than 0.02 for both). These data suggest that the Dacron pouch does not restrict pacemaker mobility parallel to the chest wall during long-term follow-up but does reduce the angle to which the pacemaker can be tilted relative to the chest wall.

Aged↗
PubMed1989

Impaired activity rate responsiveness of an atrial activity-triggered pacemaker: the role of differential atrial sensing in its prevention.

The physiological benefit of rate responsive, single-chamber cardiac pacing is well documented. We studied the activity response of nine atrially placed Activitrax II pacemakers. Seven patients were noted to have an inadequate activity-rate response with maximal pacing rates of 85 to 101 beats/min. Marker Channel analysis revealed that the upper rate timeout was reset by far-field R wave sensing, even when sensing occurred in the atrial refractory period. These 9 pacemakers were tested by atrial sensitivity adjustment for ability to exclude far-field R wave sensing, while preserving P wave sensing. Unipolar implantation data were then examined for predictors of this differential far-R and P-wave sensing. Differential atrial sensing occurred in 4/9 pacemakers (2/2 bipolar in the right atrial appendage; 0/1 bipolar in the coronary sinus; and 4/9 unipolar). An empirically developed index utilizing unipolar implant parameters discriminated outcomes for 8/9 unipolar pacemakers. We conclude that: (1) the rate responsiveness of the atrial Activitrax II pacemaker is limited by far-field R wave sensing even when this occurs during atrial channel refractoriness; (2) reprogramming atrial sensitivity to differentially sensed P and far-field R waves may restore appropriate rate responsiveness; and (3) although a unipolar implant discriminant index may correctly identify adequacy of future rate responsiveness, the atrial application of the Activitrax II pacemaker is cautioned until further validation is forthcoming, particularly when used in unipolar and coronary sinus applications.

Adult↗
PubMed1989

Iliac vein approach to permanent pacemaker implantation.

Since July 1980, 90 patients have had 95 permanent pacemakers implanted via an iliac vein approach. An incision is made superior to the inguinal ligament and the iliac vein is cannulated with a single lead for the ventricle or two leads for the atrium and ventricle. The pulse generator is placed in the subcutaneous tissue of the abdomen lateral to the umbilicus via a second incision. Overall 28 pacemaker implants were for atrial pacing, 53 for ventricular pacing and 14 were dual chamber. Nine (21%) of the atrial leads displaced and required repositioning and 5 (7%) of the ventricular leads dislodged and required revision. Lead dislodgement, especially in the atrium, remains a major weakness of the approach, and decreases its utility. Eleven percent of the last 19 atrial leads have dislodged. Nevertheless, the method is simple to perform and is presented as an alternative to the usual pectoral implantation site.

Follow-Up Studies↗
PubMed1988

Experiences with atrial pacing.

The records of 187 patients with permanent atrial pacemakers implanted between 1970 and 1980 were studied retrospectively to define the indications, outcome and short- and long-term complications of single-chamber atrial pacing. Pacemakers were implanted in 145 (77%) patients with tachybrady syndrome, 35 (19%) with sinus bradycardia and 7 (4%) with ventricular arrhythmia. Intact atrioventricular (AV) conduction was defined as absence of second- or third-degree heart block with incremental atrial pacing to a heart rate of 120 beats/min before implantation. The average follow-up was 30 months, including 87 patients (46%) who were followed an average of 48 months. Four patients developed significant conduction disease requiring placement of a ventricular lead. Complications included 4 lead fractures (all coronary sinus leads), 10 dislodgments (9 coronary sinus, 1 tined atrial "J") and 6 threshold rises requiring repositioning of the lead. Eight dislodgments occurred within an average of 5.6 days. The average increase in threshold that required repositioning occurred at 14 days. The average lead fracture occurred at 25 months. Atrial pacing is safe and effective for patients with sinoatrial node disorder (sick sinus syndrome) and intact AV conduction. Progression to clinically significant AV block is uncommon. Complications occur early with coronary sinus leads and are less common with newer leads.

Aged↗
PubMed1979

Chronotropic incompetence in exercise testing.

Patients with chronotropic incompetence, defined as a failure of the heart rate response to exercise to rise to within two standard deviations of the expected increase with exercise, where studied and compared to patients with known coronary disease by angiogram with and without ST segment depression. 72% of the patients with chronotropic incompetence but without ST depression had significant coronary heart disease. The demonstration of chronotropic incompetence in exercise testing has important predictive implications and should be looked upon as carefully as ST segment changes. There was no evidence of SA node ischemia in these patients. Intrinsic heart rate measurements done in this study suggest autonomic dysfunction as a possible pathophysiologic mechanism for chronotropic incompetence. The heart rate response to exercise may be a useful predictor of the presence and severity of coronary disease. Therefore, a predicted heart rate response with standard deviation for age and sex should be included as part of the stress test protocol.

Adult↗
PubMed1979

Predicting coronary artery disease with treadmill stress testing: changes in R-wave amplitude compared with ST segment depression.

Coronary angiograms and treadmill stress tests were reviewed independently in 108 nonconsecutively selected cases. There were 16 patients (15%) with infarcts on ECG. Changes in R-wave amplitude and ST segments during exercise were evaluated to determine the sensitivity and specificity of each as a predictor of coronary artery disease (CAD). ST segment changes had a sensitivity of 49%, and a specificity of 74%. The sensitivity increased to 55% when infarcts were excluded. R-wave amplitude changes had a sensitivity of 68% and a specificity of 84%. The sensitivity increased to 78% when infarcts were excluded. An index formed by the sum of the change in R-wave amplitude and the magnitude of ST segment change yielded a sensitivity of 76% and specificity of 78%. The sensitivity increased to 84% when infarcts were excluded. There was no statistical difference between specificities for each criteria. Of those patients with an R-wave amplitude decrease, 69% had no coronary artery atherosclerosis, while 31% had significant lesions. Of those patients with no change or an increase in R-wave amplitude, 83% had coronary artery atherosclerosis, while 17% were normal. Of the 83% with coronary artery atherosclerosis, 81% had two and three vessel disease, while only 19% had single vessel disease. No change or an increase in R-wave amplitude during treadmill stress testing is a more reliable indicator of CAD in our laboratory than ST segment changes.

Adult↗