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Biomedical subjects

M H Ellman

Publications and source records attributed to M H Ellman.

At least 37 records · Page 2Linked to original sources
PubMed1981

Prevalence of knee chondrocalcinosis in hospital and clinic patients aged 50 or older.

The prevalence of chondrocalcinosis was studied in 574 hospital and clinic patients aged 50 or older who had undergone x-ray examination of the knee. Chondrocalcinosis was found in 9.6 percent of all these patients, in 5 percent of the 50-64 age group, and in 14.6 percent of the 65-94 age group. The prevalence of knee chondrocalcinosis increased in stepwise fashion between the ages of 65 and 80. A review of the literature and of the data on our few patients over the age of 80 suggests the existence of an even higher prevalence among persons of this advanced age group.

Age Factors↗
PubMed1981

Narrowing of knee joint space in patients with pseudogout.

Abnormalities of joint space in knee roentgenograms were compared among 28 symptomatic patients with pseudogout and 2 control groups consisting of spouses of patients and hospital based patients with knee pain. Joint space narrowing was significantly more frequent in the pseudogout patients than in the 2 control groups. Division of patients and controls into 3 age groups revealed a striking degree of joint space narrowing in the youngest patients with pseudogout. Our study suggests that symptomatic patients with pseudogout have joint destruction beginning at a relatively early age. We speculated that this may reflect concurrence of chondrocalcinosis and another disease such as osteoarthritis.

Age Factors↗
PubMed1979

Acute pseudogout in chronic renal failure.

Acute pseudogout (calcium pyrophosphate dihydrate deposition disease [CPPD disease]) developed in two patients with chronic renal failure. The disease had atypical features. The calcification of the involved joints was more diffuse than the usual linear stippled calcification. The first patient, age 39, was young to have pseudogout. The second patient had pseudogout and chondrocalcinosis limited to the elbow. Review of wrist roentgenograms of 82 patients (mean age, 49.0 years), undergoing hemodialysis for chronic renal failure revealed three patients (a 3.7% incidence) with chondrocalcinosis. The incidence increased to three of 19 (15.8%) in the patients over the age of 60. Although considered uncommon, pseudogout may cause acute arthritis in chronic renal failure more often than previously suspected. Joint aspiration and identification of CPPD cystals with compensated polarized light microscopy will establish the diagnosis of pseudogout.

Acute Disease↗
PubMed1976

Septic arthritis and Reiter's syndrome in sickle cell disorders: case reports and implications for management.

Two patients with sickle cell disorders developed gram-negative septic arthritis and responded poorly to conventional managment. Unfavorable factors included (1) confusion with the nonseptic arthropathy of a sickle crisis; (2) impaired articular perfusion, perhaps related to local sickling; (3) conversion of an infecting organism to an L-form in the presence of cell-wall inhibitors; and (4) interference with cultures and antibacterial titrations of synovial fluid caused by intro-articular administration of antibiotics. Prolonged treatment with very high doses of antibiotics was required to eradicate infection in both patients. Because sickling and local hypoxia apparently interfere with defenses against infection, anemia should be corrected by transfusion. One patient had had Reiter's syndrome; the dysenteric form of this disease may be a cause of arthritis in some sicklemic patients.

Adolescent↗
PubMed1975

Toxic epidermal necrolysis associated with allopurinol administration.

Allopurinol, now established as a standard form of therapy in hyperuricemia and gout, may be associated with life-threatening skin reactions. This study reports the occurrence of toxic epidermal necrolysis TEN) in three patients receiving Allopurinol. The patients receiving allopurinol. The patients had complicated medical illnesses and were receiving various other medications, but the most apparent common denominator was allopurinol ingestion. Two other cases of TEN and five cases of severe hypersensitivity reactions with vasculitis and extensive skin manifestations, secondary to this drug, have been described in the recent literature. Allopurinol has several unique biochemical and metabolic properties that may increase its ability to cause hypersensitivity or toxic skin reactions.

Aged↗
PubMedDate not supplied

Arthritis Rounds: Ascites as the major manifestation of systemic lupus erythematosus.

It is uncommon for ascites secondary to severe peritoneal inflammation to be the major manifestation of systemic lupus erythematosus. Chronic nonspecific inflammation with a granular type immunofluorescent staining along the mesothelial layer of the peritoneum and peritoneal blood vessels was demonstrated in peritoneal tissue obtained at laparotomy. Paramyxovirus-like structures were seen within vascular endothelium. The ascites diminished with high-dose prednisone and cyclophosphamide therapy.

Adult↗
PubMedDate not supplied

Chondrocalcinosis in elderly persons.

Fifty-eight elderly people were surveyed for chondrocalcinosis with knee, hip and pelvic roentgenograms using Type M industrial x-ray film. Chondrocalcinosis was found in 16 subjects (27.6%), an incidence greater than reported in previous studies. Roentgenograms of the knees alone showed the presence of chondrocalcinosis in 15 subjects. Varus deformity of the knees, increased wrist complaints and wrist involvement with clinical arthritis were significantly more common in subjects with chondrocalcinosis. Symptoms associated with acute inflammatory arthritis were not more common in people with chondrocalcinosis.

Aged↗
PubMedDate not supplied

Acute lymphatic filariasis in an American traveler.

Acute lymphatic filariasis developed in an American traveling recreationally to Asia. The illness was characterized by fatigue, eosinophilia, and lymphedema of the arm and chest wall, but no lymphangitis, lymphadenitis, or pain. Complete resolution occurred over 1-2 years. We discuss this syndrome and describe the use of new diagnostic tests in its diagnosis and management.

Arm↗
PubMedDate not supplied

Calcium pyrophosphate dihydrate deposition in lumbar disc fibrocartilage.

Calcium pyrophosphate dihydrate deposits were found in the lumbar disc fibrocartilage in 4 patients undergoing surgery for spinal cord or nerve root compression. All of the patients had prior surgery at the same lumbar area. None of the patients had the articular or roentgenographic manifestations of calcium pyrophosphate deposition disease (pseudogout). Andres and Trainer have recently reported 7 similar patients. Calcium pyrophosphate dihydrate deposition in axial skeleton fibrocartilage may be a common finding in patients undergoing repeat spinal surgery.

Adult↗
PubMedDate not supplied

Raynaud's phenomenon and initially seronegative mixed connective tissue disease.

We report 2 young women with Raynaud's phenomenon who later developed the laboratory and clinical features of mixed connective tissue disease (MCTD). Antibodies to extractable nuclear antigens were initially negative and remained so far several years before becoming positive. Raynaud's phenomenon is common in MCTD, but laboratory and clinical evidence of the latter may not be present initially.

Adolescent↗
PubMedDate not supplied

Chronic large benign pericardial effusion complicating rheumatoid arthritis: a case report.

A 62-year-old woman with rheumatoid arthritis presented with a large pericardial effusion. Serial M-mode and 2-dimensional echocardiography over 20 months revealed no change in the amount of pericardial fluid, which had the features of a transudate. At no time did she develop any cardiac symptoms, tamponade or constriction. The course was thus "benign" and needed no surgical intervention.

Arthritis, Rheumatoid↗