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Biomedical subjects

M H Goldschmidt

Publications and source records attributed to M H Goldschmidt.

68 records · Page 4Linked to original sources
PubMed1980

Capillaria plica infection in dogs.

The prevalence, pathologic effects, and treatment of Capillaria plica infection were investigated in two breeding kennels. The prevalence of C plica infection in mature dogs in two kennels (127 dogs) was 76% and 59%. Pups less than 8 months old did not pass C plica eggs in the urine. Age, breed, or sex predilection was not observed in mature dogs. In infected dogs, hematuria, dysuria, and pollakiuria developed without secondary bacterial cystitis. A direct life cycle could not be demonstrated experimentally. Histologically, adult C plica were seen in the submucosa of the bladder and ureter, where they induced a mild inflammatory reaction and submucosal edema.

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PubMed1979

The nomenclature of periodontal epulides in dogs.

Epulides of periodontal origin are seen frequently in dogs. The classification of these tumors in the literature varies greatly and leads to much confusion when trying to compare reports from different sources. Our article reviews the literature regarding these tumors and suggests a standardized nomenclature. Three types of epulis are described. These are fibromatous epulis, ossifying epulis, and acanthomatous epulis, all of which are of periodontal origin. The three are grouped together because all have a stroma closely resembling normal periodontal ligament. The acanthomatous epulis has the potential to infiltrate locally into bone, whereas the other forms are not invasive.

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PubMed1978

Lymphangioma in four dogs.

Lymphangioma, a rare benign tumor of lymph vessels, was diagnosed in 4 dogs. The lesions were in the nasopharynx, retroperitoneum, axilla, and medial aspect of thigh. Treatment was either surgical excision or marsupialization.

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PubMedDate not supplied

X-linked ectodermal dysplasia in the dog.

A male German shepherd pup had symmetrical areas of hairlessness as well as missing and misshapen teeth. There was no family history of a similar phenotype. In biopsies of the hairless skin and foot pads there were no hair follicles, adnexal structures, or eccrine glands. These findings resemble those in ectodermal dysplasia in the Tabby mouse and anhidrotic/hypohidrotic ectodermal dysplasia (HED) in man, which are both X-linked recessive disorders and thought to be homologous gene defects. While similar cases of ectodermal dysplasia have been reported in the dog and some genetic studies carried out, definitive confirmation of X-linked inheritance of canine ectodermal dysplasia is lacking. Family studies and experimental matings using the propositus gave results that confirm X-linked recessive inheritance. On statistical grounds, it is concluded that ED in the propositus is due to a new mutation. A colony of dogs with this mutation is maintained for further study.

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PubMedDate not supplied

Canine axial skeletal osteosarcoma. A retrospective study of 116 cases (1986 to 1989).

Axial skeletal osteosarcomas were evaluated retrospectively in 116 dogs. Thirty-one tumors occurred in the mandible, 26 in the maxilla, 17 in the spine, 14 in the cranium, 12 in the ribs, 10 in the nasal cavity and paranasal sinuses, and 6 in the pelvis. Medium-sized and large dogs were most commonly affected. Females outnumbered males 2.1:1, but this varied with tumor location. The mean age was 8.7 years. Osteosarcomas of the rib occurred in significantly younger dogs (mean age, 5.4 years) than osteosarcomas at any other axial skeletal site. Pulmonary metastasis was diagnosed radiographically in 11.1% of the dogs. The median survival for dogs treated surgically was 22 weeks, the 1-year survival was 26.3%, and the 2-year survival was 18.4%. The tumor recurrence rate was 66.7%. Most dogs (79.6%) died or were euthanatized for problems associated with the primary tumor.

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PubMedDate not supplied

Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma.

The risk of developing mammary gland tumors in dogs is significantly decreased by ovariohysterectomy at an early age. However, previous studies have not found a benefit to ovariohysterectomy concurrent with tumor removal in dogs with established mammary gland tumors, suggesting that the progression of these tumors is independent of continued estrogen stimulation. The purpose of this study was to evaluate the effect of spaying and of the timing of spaying on survival in dogs with mammary gland carcinoma. Signalment, spay status and spay age, tumor characteristics, treatment. survival, and cause of death of 137 dogs with mammary gland carcinoma were analyzed. The dogs were classified into 3 groups according to spay status and spay time: intact dogs, dogs spayed less than 2 years before tumor surgery (SPAY 1), and dogs spayed more than 2 years before their tumor surgery (SPAY 2). Dogs in the SPAY 1 group lived significantly longer than dogs in SPAY 2 and intact dogs (median survival of 755 days, versus 301 and 286 days, respectively, P = .02 and .03). After adjusting for differences between the spay groups with regard to age, histologic differentiation, and vascular invasion, SPAY 1 dogs survived 45% longer compared to dogs that were either intact or in the SPAY 2 group (RR = .55; 95% CI .32-.93; P = .03). This study reveals ovariohysterectomy to be an effective adjunct to tumor removal in dogs with mammary gland carcinoma and that the timing of ovariohysterectomy is important in influencing survival.

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PubMedDate not supplied

A dermatosis resembling juvenile cellulitis in an adult dog.

A two-year-old, female Lhasa apso presented with an acute onset of fever, anorexia, lethargy, prescapular and mandibular lymphadenopathy, otitis externa, and a dermatitis involving the perioral and auricular skin. Histopathological examination of affected skin and a mandibular lymph node was diagnostic for juvenile cellulitis. Extensive hematological, serological, urine, skin, and fecal testing together with special staining, immunofluorescence, and electron microscopic examination of skin and lymph node biopsies failed to reveal an underlying etiology. After 15 weeks the condition resolved completely. This represents the first adult case of a dermatosis fitting the clinical, histological, and clinicopathological description ascribed to juvenile cellulitis.

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PubMedDate not supplied

Cutaneous horn and squamous cell carcinoma in situ (Bowen's disease) in a cat.

Cutaneous horn and squamous cell carcinoma (SCC) in situ (i.e., Bowen's disease) were documented concurrently in a cat. The cat had multiple, crusted lesions and a cutaneous horn on the right dorsal lumbar area. All the crusted cutaneous lesions were diagnosed as SCC in situ. Other findings included the presence of a thymoma and hepatoma. This cat was tested, and results were negative for feline leukemia and feline immunodeficiency viruses. At necropsy (eight months after the initial diagnosis was made) the hepatoma had ruptured, resulting in exsanguination and death.

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PubMedDate not supplied

Metastatic digital carcinoma in the cat: a retrospective study of 36 cats (1992-1998).

Thirty-six cats with bronchogenic carcinoma metastatic to the digit were identified. The mean age was 12.7 years, with no breed or sex predilection. Records from 19 cases were available for review. These cats presented with a primary complaint of lameness that involved primarily weight-bearing digits and the third phalanx. None had respiratory signs, despite the presence of pulmonary carcinoma. Course of disease was consistent in the 19 cases, with a mean survival time of 58 days from initial presentation. Amputation of affected digits was rarely palliative due to development of lesions in other digits and progressive nonrespiratory disease.

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