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M H Kramer

Publications and source records attributed to M H Kramer.

40 records · Page 3Linked to original sources
PubMed1991

De novo acute B-cell leukemia with translocation t(14;18): an entity with a poor prognosis.

Three cases of de novo acute B-cell lymphoblastic leukemia are presented, all with an unusual phenotype, involvement of translocation t(14;18) and additional chromosomal abnormalities, including translocation t(8;14) and deletion of chromosome 9. In contrast to normal FAB-L2 or FAB-L3 acute lymphoblastic leukemia (ALL), these leukemias did not express cytoplasmatic and membranous immunoglobulin. The combination of translocation t(14;18) and additional chromosomal events on the other chromosome 14 account for the lack of immunoglobulin expression. In one case a low grade follicular lymphoma was found next to a high grade Burkitt type ALL. The translocation t(14;18) takes place as a mistake in the VDJH joining in pre-B cells in the bone marrow. It is proposed that some cases of de novo ALL may arise as a blast crisis induced by genetic events, secondary to the primary t(14;18) translocation. This type of ALL seems to have a poor prognosis.

Adult↗
PubMed1976

Immune competency of nude mice bred from homozygous and heterozygous mothers.

The immune competency of nude mice born from matings of strictly homozygous nu/nu X nu/nu parents was compared to nude mice derived from the breeding of either heterozygous nu/+ mothers by nu/nu fathers or nu/nu mothers by nu/+ fathers. Spleen cells from nude mice born from heterozygous mothers had significantly higher levels of beta-bearing cells than mice born from homozygous mothers and were minimally stimulated by the T cell mitogens Con A and PHA-P. In contrast, there were no detectable maternal influences when survival of skin allografts and primary sheep red cell stimulation were studied. Homing studies of 51Cr thymocytes in term-pregnant nude mice suggest that the enhanced T cell characteristics of nude mice born of nu/+ mothers are caused in part by placental transfer of allogeneic maternal lymphocytes.

Animals↗
PubMedDate not supplied

[Surveillance of nosocomial infections: prospective study in a pediatric intensive care unit. Background, patients and methods].

UNLABELLED: BACKGROUND, PATIENTS AND METHODS: From November 1997 through May 1998, the incidence of nosocomial infections was studied prospectively in a 10-bed multidisciplinary pediatric intensive care unit in Germany. A standardized surveillance [SEKI] system based on the National Nosocomial Infection Surveillance [NNIS] System of the Centers for Disease Control and Prevention [CDC] was used. The CDC definitions for nosocomial infections were adapted to the current practice of pediatric intensive care in Germany. Infection rates were calculated as infections per 100 patients, per 1000 patient-days, and per 1000 device-days (central venous catheters, urinary-catheters, and mechanical ventilation). RESULTS: Fifteen nosocomial infections were recorded in 201 patients during 1035 patient-days. The overall nosocomial infection rates were 7.5/100 patients and 14.5/1000 patient-days. Device-associated nosocomial infection rates for urinary-catheters and mechanical ventilation were 7.2/1000 utilization-days and thus below the 75th percentile of the last NNIS report. Central line infection rates were 10.7/1000 utilization days and therefore above the 75th percentile of the NNIS data (10.2/1000). The median length-of-stay was 5.1 days. CONCLUSIONS: Surveillance data are indispensable for internal and external quality control, and prospective surveillance of nosocomial infections should become an essential component of hospital infection control programs in pediatric intensive care in Germany. The standardized calculation of (device utilization ratios and) device-specific infection rates yields results which can be compared with national and international surveillance data. SEKI meets the criteria of a practice oriented, prospective and standardized surveillance system. Considerable efforts for collecting and interpreting the required data should be balanced against the benefit of prevention of nosocomial infections in this population of critically ill persons.

Catheterization, Central Venous↗