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Biomedical subjects

M H Luntz

Publications and source records attributed to M H Luntz.

At least 19 recordsLinked to original sources
PubMed1991

The choice of surgical procedure in congenital, infantile, and juvenile glaucoma.

1. Trabeculotomy is successful in patients with an angle anomaly involving only the trabecular meshwork, but in those involving the trabecular meshwork with iris or cornea, trabeculotomy combined with trabeculectomy is recommended. 2. In cases of failed trabeculotomy or trabeculectomy, a Molteno implant can be tried, although it does not work well in patients with congenital glaucoma. 3. If all else fails, a cyclodestructive procedure is indicated and contact Nd:YAG laser cyclophotocoagulation is recommended.

Child↗
PubMed1989

Longitudinal study of serum antibody response to bovine corneal protein (BCP 54) in Behçet's disease.

Serum samples from a patient diagnosed as having active Behçet's syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behçet's patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.

Adolescent↗
PubMed1987

Intraocular pressure rise after argon laser trabeculoplasty.

Eighty-four eyes received 107 argon laser trabeculoplasty treatments at Beth Israel Medical Center between 1982 and 1984 for advanced primary and secondary glaucoma. The prelaser mean pressure was 20.25 mmHg. Pressures taken 1 1/2 hours postoperatively varied widely: the pressure rose after 47 treatments and fell or remained the same after 60. Significant increases in pressure occurred in 10 eyes, after 12 treatments; 42% of these had received burns of 0.8 watts or greater. Pressure changes were correlated with laser burn energy level. Both patients who had significant increases in pressure initially were retreated again--in the same eye--at another time had similar increases in postoperative pressure again, even with lower energy levels. Comparison with the results of previous reports highlights the advantages of limited treatment to the anterior trabeculum with low energy levels.

Aged↗
PubMed1987

Subscleral Scheie operation for advanced glaucoma.

The subscleral Scheie procedure is most effective in advanced glaucoma patients with IOP of 35 mm Hg or more and in those patients in need of a secondary or tertiary procedure. The surgical technique is described.

Evaluation Studies as Topic↗
PubMed1983

Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).

Two homosexual males with the "gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. In one patient cytomegalovirus was cultured from a vitreous biopsy. Autopsy revealed disseminated cytomegalovirus in both patients. Widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusions of cytomegalovirus. Electron microscopy showed herpes virus, while immunoperoxidase techniques showed cytomegalovirus. The altered cell-mediated response present in homosexual patients may be responsible for the clinical syndromes of Kaposi's sarcoma and opportunistic infection by Pneumocystis carinii, herpes simplex, or cytomegalovirus.

Acquired Immunodeficiency Syndrome↗
PubMed1979

Congenital, infantile, and juvenile glaucoma.

The appearance of the anterior chamber angle shows considerable variation in eyes with glaucoma caused by congenital or developmental causes. These differences, in over 100 eyes studied, correlate well with the effectiveness of trabeculotomy in controlling the intraocular pressure. In angles harboring what is probably embryonic mesoderm (although they may vary in their gonioscopic appearance), prognosis for control of IOP by trabeculotomy is excellent, while in those that show evidence of a fibrotic process at the limbus, the prognosis for trabeculotomy is hopeless. The latter, once recognized, should be treated by trabeculectomy, this condition being the only good indication for trabeculectomy in these eyes.

Anterior Chamber↗
PubMed1978

Ocular hypertension: a comparative follow-up of black and white patients.

Forty-four eyes in 25 black patients are compared with 92 eyes of 47 white patients in a population with ocular hypertension followed up for 1 to 12 years in a glaucoma clinic. The black patients present at a younger age than the whites and their mean initial intraocular pressure is significantly higher. The fact that more black ocular hypertensives developed glaucoma--8 eyes (18.1%) in the black population as compared with 5 eyes (5.4%) in the white population--is attributed to these two differences.

Adult↗
PubMed1978

Influence of pH on the efficacy of pilocarpine.

Pilocarpine 4% solutions at pH 4.1 and 5.8 were compared in a double-blind clinical trial on 24 eyes of patients with primary open-angle glaucoma. Each drug was used over a period of 1 week. No significant difference in the lowering of intraocular pressure was found, and the near-neutral solution of pilocarpine was found to be equally stable when compared to the acid solution over a 6-month period.

Clinical Trials as Topic↗
PubMed1978

A clinical approach to the medical treatment of uveitis.

Uveitis is divided into five clinical groups based on its severity and natural history. By using this classification appropriate and graded forms of therapy can be applied to individual patients with uveitis. In Group 1 patients (anterior uveitis syndrome) topical cortisone drops or ointment will control the disease. Group 2 (posterior uveitis) patients require local steroids (topical, subconjunctival or retrobulbar) and systemic steroids. Appropriate specific therapies are indicated if a causal organism can be identified. Patients in Groups 3 (cyclitis), Group 4 (uveitis in children) and Group 5 (severe intractable uveitis) are exposed to a high risk of cystic macula degeneration and must be treated with local and systemic cortisone and cytotoxic drugs if the steroid fails to control the inflammation or if cortisone has to be used excessively high dosage. The recommended regime of treatment is summarised in the diagram in figure 7.

Administration, Topical↗
PubMed1977

Trabeculotomy ab externo and trabeculectomy in congenital and adult-onset glaucoma.

In one prospective study, 75 eyes (47 children with congenital glaucoma) were treated by trabeculotomy. Intraocular pressures were controlled in 93.4% after one or more trabeculotomy operations. In five eyes the intraocular pressure was not controlled and these had a fibrovascular membrane in the angle, extending over the trabeculum and iris base with finger-like processes over the peripheral iris. The eyes that had successful operations did not have this appearance. In a second study trabeculotomy in adult-onset open-angle glaucoma had a high rate of failure (30%) including the use of postoperative medication. Nineteen eyes (17 patients) were operated on, 13 successfully. Another group of 19 eyes (17 patients) were treated by trabeculectomy, with the same follow-up period. The one failure (5%) occurred in an eye in which the angle appeared to be totally closed on gonioscopic examination. The operation was equally effective in black and white patients.

Glaucoma↗