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Biomedical subjects

M H Narahara

Publications and source records attributed to M H Narahara.

3 recordsLinked to original sources

Superior segmental optic hypoplasia. A sign of maternal diabetes.

In a review of 10 patients with superior segmental optic nerve hypoplasia, all of whom were the children of diabetic mothers, 17 of 20 eyes had one or more of four characteristic findings in the optic disc: relative superior entrance of the central retinal artery, pallor of the superior disc, superior peripapillary halo, and thinning of the superior peripapillary nerve fiber layer. We believe that the presence of these four signs of superior segmental optic nerve hypoplasia strongly suggests maternal diabetes.

Adult↗

Congenital quadrantanopia with occipital lobe ganglioglioma.

A 24-year-old man with recent-onset seizures was found to have an occipital lobe ganglioglioma with homonymous quadrantanopia and trans-synaptic atrophy of retinal nerve fibers. This association indicates that gangliogliomas may arise during neural development and exist for many years before onset of symptoms.

Adult↗

Optic nerve hypoplasia.

Optic nerve hypoplasia is an easily overlooked, nonprogressive developmental anomaly which results in a wide range of visual deficits. It is frequently associated with clinically significant central nervous system and endocrine abnormalities. Maternal substance abuse is increasingly recognized in many cases. A supranormal regression of optic nerve axons in utero, rather than a primary failure of differentiation, is proposed as the pathogenesis.

Humans↗