Biomedical subjects

M H Roe

Publications and source records attributed to M H Roe.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Comparative evaluation of kits for rapid diagnosis of group A streptococcal disease.

The role of rapid diagnostic tests for Group A streptococcal disease has not been firmly established. High quality data concerning these rapid streptococcal tests are not available; current information does not allow for direct test comparisons to be made; the superiority of rapid diagnostic technology over traditional throat cultures has not been proved. Subgroups which might benefit from this technology could include those who (1) are severely ill, (2) have been excluded from school or day care because of a streptococcal infection, (3) have a history of rheumatic fever and are not taking antimicrobial prophylaxis or (4) live in a confined residential setting. Each available test kit has a mixture of performance features, allowing for individual choices based on office and practice needs. Product technology is expected to change rapidly. Reassessment of any current decision may well lead to a different conclusion in 6 to 12 months.

Evaluation Studies as Topic↗

PubMedDate not supplied

Simultaneous infection with Bordetella pertussis and respiratory syncytial virus in hospitalized children.

We compared three groups of hospitalized children with Bordetella pertussis infection, respiratory syncytial virus (RSV) infection and dual B. pertussis/RSV infections in an effort to establish clinical and laboratory criteria by which to distinguish children with dual infections from children infected with either organism alone. The groups were compared for admission laboratory data, history of present illness, perinatal history and immunization history. Children with pertussis were more likely to have been premature (less than 37 weeks gestation) than children with RSV infections only (11 of 29 vs. 1 of 22, chi square test, 5.94, P less than 0.02). Other than B. pertussis and RSV fluorescent antibody testing and culture, there were no laboratory or clinical criteria by which to differentiate these children consistently at the time of hospital admission. For purposes of medical management and infection control, pertussis or simultaneous infection with pertussis should be considered in young children hospitalized for presumed viral respiratory illness.

Bordetella pertussis↗

PubMedDate not supplied

Outbreak of group A streptococcus septicemia in children. Clinical, epidemiologic, and microbiological correlates.

OBJECTIVE: To determine the epidemiologic, clinical, and microbiological features of group A streptococcus septicemia in children. DESIGN: A descriptive series of 34 cases over an 11-year period from 1980 through 1990. SETTING: An academically affiliated tertiary-care pediatric hospital, the principal referral center for the state of Colorado and surrounding states. PARTICIPANTS: Thirty-four patients with positive blood cultures for group A streptococcus (33 medical records were available). MAIN OUTCOME MEASURES: Yearly incidence and clinical features of cases; microbiological features of isolated organisms. RESULTS: There was a significant increase (P = .01) in the incidence of group A streptococcus bacteremia over an 11-year period, with 14 (41%) of these cases occurring in 1989 and 1990. Patients had a rapidly progressing illness, usually without preceding pharyngitis. The prominent M and T types were 1 (4) and 12 (4). Eleven (73%) of the 15 strains produced pyrogenic exotoxin B that significantly correlated with production of proteinase. CONCLUSION: There appears to be an increase in group A streptococcus bacteremia in children that is associated with a strain phenotype that suggests a change in organism virulence.

Adolescent↗