Skin tumors of the lower extremities.
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Biomedical subjects
Publications and source records attributed to M H Samitz.
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Distinctive syndromes correlating skin manifestations and gastrointestinal malignancies are described. The skin lesions may precede, accompany, or follow the primary disease in the gastrointestinal tract and can be important diagnostic clues. They should alert the physician to the possibility that his patient may have an associated internal cancer.
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The case of a patient with a recurrent, painful ulceration on the lower leg, clinically and histologically resembling hidradenitis suppurativa, is presented. The fact that this site is devoid of apocrine glands supports the concept that apocrine involvement in hidradenitis suppurativa is coincidental and that these glands are involved secondarily. It is suggested that in this patient the pathogenesis of the disease is follicular occlusion rather than selective apocrine poral closure.
This report reviews data relating to the nickel hazard from implanted prostheses. It is shown that nickel is released from stainless steel prostheses by the action of sweat, blood and physiological saline solution. In laboratory animals, solubilized nickel isn the tissue near the implant.
Under ordinary working conditions in which grinding fluids were used, the presence of nickel or chromates was not detectable by spot testing. Laboratory studies, however, indicate that nickel can be leached from the machined metals.
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The determination of nickel by instrumental neutron activation is presented. The 58Ni (n, p) 58Co reaction and high-resolution gamma spectroscopy were employed in these measurements. The nickel content of human hair was found to be more dependent upon the sex of the donor than upon other parameters. Mean values for males (1.01 +/- 0.23 ppm) and females (4.21 +/- 0.54 ppm) agreed with values for the nickel content of hair obtained by other methods in most cases. Nickel sensitivity was not reflected in the nickel contents of hair in the female.
A patient had umbilical metastasis from a carcinoma of the stomach. The umbilical lesion (Sister Joseph's nodule) is a characteristic sign of metastatic tumor, and the diagnosis was confirmed by biopsy. The cutaneous metastasis was associated with visceral metastases.
Sweat and household detergents were shown to have the capacity to release nickel from stainless steel. This finding substantiates the thesis that the American-style stainless steel kitchen and other stainless steel commodities can be sources of skin contact allergy with nickel. Furthermore, a negative spot test (DMG) does not reflect the "safety" of a nickel alloy.
A technique for the induction of sensitization in pigs with a nickel-alanine conjugate has been reported by other investigators. Similar results were observed in our experiments in mini-pigs. However, using the identical technique, we were unable to induce sensitization in guinea pigs with NiSO4, with nickel-alanine or other nickel-amino acid complexes, or with a complex of nickel with soluble guinea pig skin extract. These results indicate that nickel-amino acid complexes and nickel-guinea pig skin complex were not antigenic in guinea pigs with this technique. Hypotheses for the apparent failure to induce sensitization are proposed.