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Biomedical subjects

M H Webster

Publications and source records attributed to M H Webster.

At least 37 records · Page 2Linked to original sources
PubMed1984

The results of breast reconstruction following mastectomy.

This paper is a retrospective study of the techniques, complications and results of breast reconstruction following mastectomy in 82 patients, 66 of whom had breast cancer. The mean length of follow-up was 3 years 8 months. Of the 74 patients who were reviewed 61 were pleased with the results. Eight patients died, 7 of them from disseminated breast cancer. In our experience breast reconstruction is a very worthwhile procedure in motivated patients and may reduce the psychiatric morbidity of mastectomy.

Adult↗
PubMed1983

The effect of temperature on blood flow in island and free skin flaps: an experimental study.

Skin blood flow is especially susceptible to temperature change, as the skin has an important role in body thermoregulation. The effect of temperature on blood flow in an experimental skin flap model in the dog has been measured using an electromagnetic flowmeter. the flap blood flow varied directly with temperature. In the range 22 degrees C-38 degrees C, this relationship was linear, the increase in the flap blood flow being 3.41% per degree Celsius. However, outside this temperature range the change was much greater.

Animals↗
PubMed1982

Survival after replantation.

Over a seven-year period in one unit performing replantation surgery 63 parts were replanted in 49 patients with an overall survival rate of 60%, which represents a worthwhile salvage of tissue otherwise not available for reconstruction. As the median operation time was eight hours (range 5-22) the implication of providing such prolonged operative procedures on the resources of the Health Service must be seriously considered. Yet there is a failure of awareness among the medical profession of the possibilities of such treatment, and potentially viable parts may be being discarded.

Adolescent↗
PubMed1981

Impaired bacteriological responses in babies after maternal iron dextran infusion.

The effect of a total dose infusion of iron dextran in pregnancy on 15 mothers and their babies was compared with 19 controls. The bacteriostatic effect and opsonising ability of the sera, of babies born to the treated mothers, were considerably impaired. This was associated with a significantly lower transferrin concentration in these mothers. Although these in vitro tests were not associated with an increase in overt infection during the perinatal period, they suggest the need for caution in the use of total dose infusions in pregnancy.

Blood Bactericidal Activity↗
PubMed1980

Monoamine metabolites in cerebrospinal fluid of depressive subgroups.

Lumbar punctures were performed on 69 patients who met Research Diagnostic Criteria (RDC) for major affective disorder, while they were drug-free and depressed. None of the patients met RDC for alcoholism. Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by fluorometry and 3-methoxy-4-hydroxyphenylglycol (MHPG) by gas chromatography. Family histories were ascertained by systematic interviews of patients and their relatives, and diagnoses were made by family history diagnostic criteria (Andreasen et al., 1977). Depressed patients with alcoholism in a first degree relative had significantly lower levels of 5-HIAA and MHPG than patients without a family history of alcoholism (p < 0.05). No difference in HVA levels was found. The metabolite differences remained significant when the influence of sex ratio was considered. These results are in agreement with previous work linking alcoholism to abnormal serotonin metabolism. They provide further biochemical evidence of distinct genetic subtypes of affective disorder along lines suggested by Winokur (1979a, 1979b), and illustrate the usefulness of the family history method in defining patient subgroups.

Adult↗
PubMed1977

The problem of radiation dosage in the measurement of skin blood flow by xenon-133.

The skin dose arising from the use of xenon-133 in the measurement of skin blood flow has been calculated for several situations. The results indicate the importance of prior assessment of radiation dose in any technique involving the use of radionuclides. Cases where particular care must be taken have been indicated and practical methods of reducing the dose are suggested.

Humans↗