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Biomedical subjects

M H Yang

Publications and source records attributed to M H Yang.

At least 19 recordsLinked to original sources
PubMed1992

Outcome of 143 pregnancies conceived by assisted reproductive techniques.

One hundred and forty-three pregnancies conceived by assisted reproductive techniques (ART) from October 1985 to June 1989 in the National University Hospital, Singapore, resulted in 66 deliveries and 89 babies. There were 27 (18.7%) biochemical pregnancies, 44 (30.7%) clinical miscarriages and 6 (4.2%) ectopic pregnancies when total pregnancies were considered. Of those who continued pregnancy to second trimester multiple births occurred in 20 (13.3%) patients. A high incidence of vaginal bleeding and hypertension in pregnancy was noted in 32 (48.5%) patients and 18 (27.3%) patients, respectively. Caesarean section was the method of delivery in 48.5% of patients. Twenty-six (29.2%) babies required admission to the neonatal intensive care unit. All babies except one set of twins delivered at 24 weeks of amenorrhoea survived. Fetal abnormality was noted in 2 cases.

Adult↗
PubMed1992

Multiple lymphomatous polyposis of the gastrointestinal tract--a report of two cases with immunohistochemical studies.

We describe two cases of multiple lymphomatous polyposis in the gastrointestinal tract from the esophagus to the rectum. Clinical findings, histopathologic and immunohistochemical findings in paraffin embedded tissue are discussed. It is important to recognize this rare form of gastrointestinal lymphoma because of the prognostic and therapeutic implications.

Antigens, CD↗
PubMed1992

A clinicopathologic study on the diffuse malignant lymphoma--a morphologic and immunophenotypic analysis in 62 patients at Harbor-UCLA Medical Center.

In order to compare the prognoses of patients with diffuse malignant lymphomas on the basis of histology and immunophenotypes, we retrospectively studied 62 cases of diffuse lymphoma arising in lymph nodes. We also evaluated the reactivity patterns of monoclonal antibodies (MoAb) LN1, LN2 and LN3 to determine the criteria for making a differential diagnosis in B cell lymphomas. The immunologic phenotypes were determined by the avidin biotin peroxidase complex method, using frozen or paraffin fixed tissues. The majority (66.3%) were B cell with the remaining 20.9% being T cell and 12.9% were non-B, non-T cell lineage. Immunological heterogeneity was found especially in the mixed small and large cell and the immunoblastic lymphomas. There was no significant difference between B- and T-cell lymphomas with respect to survival and death (P > 0.05). Histologically 79% (49/62) of the lymphoma was large cell and 21% (13/62), small cell lymphoma. There was a difference in prognosis between low, intermediate and high-grade of lymphomas. However there were no significant differences among the subtypes of the diffuse aggressive lymphomas. Factors associated with poor prognosis were advanced stages (P < 0.025) and histology of the malignant lymphomas. MoAb LN1, LN2 and LN3 gave positive staining in 83.3%, 91.7% and 60% of B cell lymphomas, respectively. The most common phenotypic pattern in B cell lymphomas was LN1+, LN2+, LN3+/-, suggestive of follicular center cell origin. As a panel, phenotypic patterns of MoAb LN1, LN2 and LN3 may be useful in differentiation of follicular center cell lymphoma from others.

Adolescent↗
PubMed1992

[Morphological study of reticulo-epithelial cells in atrophic thymus].

Anti-keratin and PAP immunohistochemical reaction on atrophic thymus collected from 97 autopsies were studied. Among them, 61 cases belonged to the severs type, whose reticulo-epithelial cells were falling into 4 types: the normal type, the centrally focused type, the diffused type and the depletive type. In 37 out of 61 cases, the reticulo-epithelial cells showed proliferation, especially in the medullary zone. All of 7 cases known as physiological involutional thymus turned to depletive type. 11 cases of atrophic thymus studied by scanning electron microscopy had been classified morphologically into 3 patterns, namely: the reticular form, the honey-combed form and the depletive form respectively.

Atrophy↗
PubMed1992

[Estrogen receptor in female lung carcinoma].

80 cases of female lung carcinoma were assayed with avidin-biotin complex method for estrogen receptor (ER) and 73.8% cases revealed positive reaction. The 3 expressive types were cytoplasmic, all cellular and nuclear. There were no correlations between ER content and age, blood type, histologic types, size of tumor and metastasis of regional lymph nodes, but obvious correlations between ER content and prognosis. The 5 year survival rate in ER negative patients (72.7%) was greatly higher than in positive patients (8.8%) (P < 0.01). All had better prognosis in ER negative patients above and below 50-year groups.

Adenocarcinoma↗
PubMed1992

[Survey of heavy metals in traditional Chinese medicinal preparations].

Traditional Chinese medicinal preparations are still widely used by natives in Taiwan. Some traditional Chinese medicine prepared with ancient formulas have been found to contain some heavy metals. There has been an occasional pediatric case admitted with heavy metal intoxication. In the last two years, we collected 11 ancient formula drug samples from the families of the patients. We detected the heavy metals with an inductively-coupled plasma atomic emission spectrometry and a graphite furnace atomic absorption spectrometry. The final result of our report reveals the problem of heavy metals in traditional Chinese medicinal preparations as being very serious.

Drugs, Chinese Herbal↗
PubMed1992

Serum sialyl stage-specific embryonic antigen levels in adenocarcinoma of the lung.

The serum levels of sialyl stage-specific embryonic antigen (SSEA-1) in 67 patients with adenocarcinoma of the lung were studied to assess their values for diagnosis. A solid-phase immunoradiometric sandwich assay with an FH6 monoclonal antibody was used. Another 49 healthy adults, 52 patients with benign pulmonary diseases, and 142 lung cancer cases with cell types other than adenocarcinoma were evaluated for comparison. The mean (+/- S.D.) levels (U/mL) for adenocarcinoma of the lung, lung cancer other than adenocarcinoma, benign pulmonary diseases and normal subjects were 182.9 +/- 309.7, 53.5 +/- 22.6, 38.9 +/- 17.1 and 30.5 +/- 6.5, respectively. The mean serum sialyl SSEA-1 level was significantly higher in adenocarcinoma of the lung, compared with lung cancer other than adenocarcinoma (p < 0.001), benign pulmonary diseases (p < 0.001), or normal subjects (p < 0.001). For late stage (Stages III and IV, n = 58) adenocarcinoma of the lung, the mean (+/- S.D.) serum sialyl SSEA-1 level (204.3 +/- 327.6 U/mL) was significantly higher than that of earlier stage (Stages I and II, n = 9) adenocarcinoma of the lung (39.9 +/- 19.3), p < 0.001. There was no statistical difference among the mean serum levels of various histologic types of lung cancer other than adenocarcinoma (p > 0.05). In the lower range of values, considerable overlap existed between adenocarcinoma of the lung and lung cancer other than adenocarcinoma. However, very high sialyl SSEA-1 levels (> 140 U/mL) were only encountered in late stage adenocarcinoma of the lung (22/58).(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1991

Giant cell tumor of the scapula associated with secondary aneurysmal bone cyst.

Giant cell tumors are distinctive neoplasms characterized by a profusion of multinucleate giant cells scattered throughout a stroma of mononuclear cells. Most giant cell tumors are found at the epiphyses of long bones, especially around the knee joint. Flat bone involvement is rare. However, a case of giant cell tumor with secondary aneurysmal bone cyst was encountered at the scapula of a 25-year-old man. Since the occurrence of a giant cell tumor with secondary aneurysmal bone cyst on flat bones (i.e., the scapula) is extremely rare, the above-mentioned case is worthy of reporting.

Adult↗
PubMed1990

Effect of wet decomposition methods on the determination of cobalt, copper, selenium, and zinc in biological samples using electrophoresis.

A method combining radiotracer techniques with paper electrophoresis to investigate the optimal decomposition conditions for cobalt, copper, selenium, and zinc in rat liver samples is described. After oral and intraperitoneal administration of the respective nuclides of 60Co, 64Cu, 75Se, and 65Zn solutions, the livers of the tested rats are removed and decomposed with a nitric and sulfuric acid mixture. The completeness of decomposition is investigated by measuring the respective radionuclide-containing species in the decomposed samples by electrophoretic analysis. The results indicate that the Co- and Se-containing liver samples are more easily decomposed than those containing Cu and Zn under the specific conditions. The same decomposition effects are observed for ingested radioisotopes as for intraperitoneally injected ones. The possible connection of decomposition with the analytical error is discussed.

Animals↗
PubMed1990

Instrumental neutron activation analysis of gallstones.

Four kinds of gallstones from 40 patients have been analyzed for the presence of a total of 18 elements by instrumental neutron activation analysis. Of these elements, Ca, Mg, Fe, Co, Zn, Na, and Cl are found in the core of all types of stones. The differences in elemental composition of the various types of stones as well as the differences in the cross-sectional layers of stones are statistically evaluated.

Cholelithiasis↗
PubMed1990

Symptomatic subependymoma--a case report.

Subependymoma is a rare, slow-growing, benign noninvasive tumor of the central nervous system that may be located in the fourth ventricle, the septum pellucidum, the third and the lateral ventricles, the aqueduct, and the proximal spinal cord. Symptoms, if any, usually result either from direct compression of the brain stem or from acute hydrocephalus due to occlusion of the foramen of Monro or aqueduct of Sylvius. In this report, we describe a case of subependymoma of the lateral ventricle with headache in a young female patient. This is the first reported case subependymoma in Korea that was documented along with Magnetic resonance image.

Adult↗
PubMed1990

Nasal hemangiopericytoma--a case report.

A case of rare intranasal hemangiopericytoma in a 68-year-old male was reported with typical histological and ultrastructural findings. The lesion clinically resembled a nasal polyp. The experience in the present case raised the need for differential diagnoses of vascularised spindle cell tumors and of traditional hemangiopericytoma in soft tissue.

Aged↗
PubMed1990

Retroperitoneal teratoma with predominance of nephroblastic elements--a case report.

The morphological features of a retroperitoneal teratoma in a 10-month-old girl are reported. Unlike the usual pattern of the teratoma, this tumor was composed predominantly of nephroblastomatous tissue. Histologically, glomeruloid and tubular structures were identified in nests of undifferentiated blastemal elements. Hyaline cartilage, adipose tissue, glial tissue and glands lined by mucin-secreting columnar epithelium were minor elements. A focal cystic structure lined by thin flattened epithelium was also noted. Retroperitoneal teratoma with predominance of nephroblastic elements is of interest not only because of its rarity but also because it needs to be differentiated from extrarenal Wilms' tumor, since both of these tumors have different origins.

Diagnosis, Differential↗
PubMed1989

So-called sclerosing hemangioma of the lung--two cases report with ultrastructural study.

Sclerosing hemangiomas of the lung are benign neoplasms of uncertain histogenesis. We analysed two cases of sclerosing hemangiomas of the lung with histochemistry and electron microscopy. They had a variegated histologic appearance characterized by an admixture of solid, hemorrhagic, papillary and sclerotic lesions. Characteristic uniform round cells, unique to this tumor, were found within the stroma in all lesions. In the electron microscopic examination, we found Weibel-Palade bodies like small bodies in the tumor cells. We suspect hypothesis originating in the endothelial cell can not be completely excluded yet. Sclerosing hemangioma is a distinct clinicopathologic entity and should be distinguished from other benign neoplasms or inflammatory lesions of the lung.

Endothelium↗
PubMed1987

Determination of major, minor and trace elements in urinary stones by neutron activation analysis.

In five kinds of human urinary stones 18 elements have been identified by instrumental neutron activation analysis (INAA). From the results it may be concluded that calcium is the most important initiating cation, magnesium is the second most significant one, and Na, Cl, Sr, Zn, Fe, Br and Co may also play an important role in the stone formation. The results indicate also that ions like Ca, Br and Cu are easily incorporated into the nucleus to form a urate stone; Mg and Sr, into the nucleus to form a magnesium ammonium phosphate stone; and Zn, into the nucleus to form a calcium oxalate combined with apatite stone. The differences in elemental composition among the different kinds of stones as well as across the layers of stones are statistically evaluated.

Humans↗