PubMed Health⌕ Search

Biomedical subjects

M H Zhao

Publications and source records attributed to M H Zhao.

24 records · Page 2Linked to original sources
PubMed1994

[Effect of sheng mai san on lipid peroxidation in acute myocardial infarction patients].

The effect of Sheng Mai San (SMS) on the coronary heart disease (CHD) patients (30 angina pectoris and 68 acute myocardial infarction, AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood were decreased and the content of malondialdehyde (MDA) in plasma was increased in CHD patients in comparison with the healthy controls (P < 0.001). When SMS was orally administered in 38 AMI patients, both SOD and GSH-Px activities were increased and the level of MDA decreased (P < 0.05), and these changes were even more significant when SMS was further ingested for another two weeks (P < 0.001). At the same time, it was found that the changes of SOD, GSH-Px and MDA in the control group (30 AMI patients not taking SMS) were not significantly different (P > 0.05). It could be assumed that the pathogenesis of CHD is associated with free radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effective free radical scavenger, which would ameliorate the lipid peroxidation damage. Thus, SMS could be administered in the prevention and the treatment of CHD.

Aged↗
PubMed1993

[The renal involvement of primary vasculitis: clinical and pathological analysis of 5 cases].

Primary vasculitis, include microscopic polyarteritis (MPA) and Wegener's granulomatosis (WG), is one of the causes of Glomerulonephritis and renal failure. Recently antineutrophil cytoplasmic autoantibodies (ANCA) is considered to be a very important tool for the diagnosis of MPA and WG. The management of ANCA was performed in 42 patients with variant primary glomerulonephritis with crescents formation or sclerotic glomerulonephritis, 5 of them show positive, appeared as a pattern of P-ANCA. Most of the patients were old male, with fever, malaise, weight loss, anemia, muscle and joint pain, some of them have chronic cough, even hemoptysis, opacities in middle-lower fields of both lungs, which didn't response to antibiotics therapy. This is the first report about renal involvement of primary vasculitis from China. Our result suggest that primary vasculitis is not a rare course of renal failure in China.

Adolescent↗
PubMed1990

[Effects of clonidine and norepinephrine on rabbit pulmonary artery strips with or without endothelium].

Relaxing responses of strips of rabbit pulmonary artery (RPA) with endothelium (+E) to norepinephrine (NE) during sustained contraction with KCl 20 mmol/L in the presence of propranolol (Pro) 10 mumol/L and prazosin (Pra) 1 mumol/L were more sensitive than those without endothelium (-E) to NE. These responses were inhibited by yohimbine (Yoh) 1 mumol/L. However, the relaxing responses of the strips to clonidine (Clo) were not different between RPA strips +E and -E in the presence of Pro+ Pra or Pro + Pra + Yoh 1 mumol/L. Relaxing responses of RPA strips -E precontracted by phenylephrine (PE) 1 mumol/L to Pra and Clo were greater than that of those precontracted by KCl 20 mmol/L. The relaxing responses of these strips precontracted by PE to Pra were larger than those precontracted by PE mumol/L; but that of those precontracted by PE and Clo to Yoh were not different. The results suggest that integrity of the endothelium is an important factor in the relaxing responses of RPA strips to NE. The relaxing effect of Clo on RPA strips precontracted by KCl 20 mmol/L may be due to alpha 1-adrenoceptor blockade on smooth muscle cells of the RPA strips.

Animals↗