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Biomedical subjects

M Högye

Publications and source records attributed to M Högye.

12 recordsLinked to original sources
PubMed1991

Hyperlipemia and hyperlipoproteinemia [HLP] screening among the children from premature myocardial infarction risk families.

Serum lipids and lipoproteins were investigated in the premature myocardial infarction (PMI) risk families before 45 years of age with the aid of screening for hyperlipemia and hyperlipoproteinemia (HLP): in the case of 174 persons from Csongrád County from the Departments of Internal Medicine I and II and of 42 patients (fathers) suffering from PMI and their 79 "high risk" children from Heves County. In the investigated three groups of "high risk" children the genetically determined antiatherogenic HDL-Ch level diminished in 34.8, 52.3, 40.5 per cent. Significant negative correlation was detected between the serum HDL-Ch and beta-lipoprotein; significant positive correlations were found between the HDL-Ch and the serum lipase activity; between the beta-lipoprotein and the phospholipid level; significant negative correlation was proved between the HDL-Ch and the phospholipid level in the group of PMI patients and their offsprings. The Ch/Tg, and the HDL-Ch ratios were significantly diminished in the PMI patients' group against the risk children' group, while the Ch/HDL-Ch rate was significantly elevated.

Adolescent↗
PubMed1989

[Direct and indirect immunofluorescence studies in congestive myocardial diseases].

Immunfluorescence examinations were made on 118 patients with congestive cardiomyopathy. Standard techniques of direct immunfluorescence (DIF) were employed on myocardial biopsy material in 61 cases, and of indirect immunfluorescence (IIF) on the serum in 89 cases. On the basis of the assumed aetiologies, the patients were classified into 6 groups: definitely alcoholic, presumably alcoholic, familial, peripartum, chronic myocarditic and idiopathic; studies were then made of the frequencies of pathological immunological processes in the individual groups. The highest incidences of DIF-positive cases were observed in the familial, peripartum, chronic myocarditic and idiopathic groups (67-87%). In the presumably alcoholic group the corresponding incidence was 37%, and in the definitely alcoholic group it was 25%, in contrast with expectations. Interestingly, very strong IIF-positive reactions too were observed in these alcoholic groups. It is possible that, besides the effect of alcohol, the fact that the immune background becomes pathological is also a significant factor in the emergence of the congestive cardiomyopathy in the alcoholic groups.

Alcoholism↗
PubMed1989

[Morphologic studies of emdomyocardial biopsy specimens].

Authors have studied 153 heart biopsies of 120 patients and results of 133 endomyocardial biopsies studied by light and electron microscopy are described. In addition to typical morphological picture of myocarditis, in majority of cases non-specific changes appearing also in idiopathic cardiomyopathy were observed and their ultrastructure is fully stated. Results are compared to relevant data of literature. Indications, informative value, practical and scientific research significance of myocardial biopsies are briefly overviewed.

Biopsy↗
PubMed1987

Hypertrophic cardiomyopathy associated with congenital deaf-mutism.

A family is presented in which there is a high incidence of hypertrophic cardiomyopathy and congenital deaf-mutism. The two abnormalities occurred together in 2 cases, and the syndrome was strongly suspected in a third individual. Hypertrophic cardiomyopathy without deaf-mutism was observed in a further 2 cases. Hypertrophic cardiomyopathy is inherited by an autosomal dominant mode; that occurring together with deaf-mutism is also probably inherited dominantly.

Adult↗
PubMed1986

Comparative echocardiographic study of junior and senior basketball players.

The echocardiographic data on 14 junior and 15 senior players in a first-division basketball club were compared. No difference was found between the senior and junior players as regards the thickness of the interventricular septum (11.47 vs 11.21 mm) or the thickness of the posterior wall of the left ventricle (9.8 vs 9.86 mm). The adults displayed a larger left ventricular end-diastolic diameter (56.8 vs 53.6 mm, P less than 0.05), end-diastolic volume (194 vs 164 ml, P less than 0.05), stroke volume (142 vs 116 ml, P less than 0.05), right ventricular diameter (27.9 vs 23.2, P less than 0.01), aortic root diameter (35.0 vs 32.0, P less than 0.05), and left atrial diameter (42.7 vs 37.2, P less than 0.01). However, among these, only the stroke volume and right ventricular diameter remained significantly different after normalization to body surface area. A significant difference could not be demonstrated in the linear ejection fraction, the ejection fraction, or the fractionated interventricular septum and posterior wall thicknesses. The examinations indicated that left ventricular hypertrophy had fully developed by the age of 18 years in the basketball players and that there was no further enhancement in adults. However, the left ventricular, right ventricular, and left atrial volume were larger in the adults than in the junior players.

Adolescent↗
PubMed1986

Three-year echocardiographic follow-up study on canoeist boys.

The echocardiographic parameters were followed for 3 years in 15 boys aged 13 years on average, who were beginning competitive canoe race training, and were compared with the corresponding data on 17 boys of the same age who did not take part in sports. As compared to non-sporting boys the 13-year-old canoeist boys had a larger left ventricular end-diastolic diameter (46.13 +/- 4.64 mm vs 44.35 +/- 3.06 mm), a thicker left ventricular posterior wall (7.47 +/- 0.74 mm vs 6.47 +/- 1.18 mm) and particularly a thicker interventricular septum (8.33 +/- 1.18 mm vs 7.59 +/- 1.6 mm) just after they began sport, in spite of the fact there were no significant differences between the two groups in age, height, weight and body surface area. The preexisting difference in left ventricular hypertrophy between the two groups increased significantly during the 3-year follow-up period. The thickness of the left ventricular posterior wall in diastole increased to 9.20 +/- 1.01 mm vs 8.24 +/- 0.83 mm (p = 0.006), and that of the interventricular septum to 10.73 +/- 1.58 mm vs 9.59 +/- 1.18 (p = 0.025). The hypertrophic index and the left ventricular mass corresponded to the data given above (9.97 +/- 1.25 mm vs 8.91 +/- 0.94 mm, p = 0.01; and 261 +/- 50.7 g vs 202.83 +/- 45.8, p = 0.002, respectively). The canoeist boys had a slightly larger aortic root diameter at the beginning, and this difference increased and became more significant during the 3 years (29.4 +/- 2.39 mm vs 27.18 +/- 1.88 mm, p = 0.006). There were no significant differences between the two groups in the size of the left atrium, the fractional shortening of the left ventricle and the calculated ejection fraction and stroke volume.

Adolescent↗