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Biomedical subjects

M Hüttel

Publications and source records attributed to M Hüttel.

7 recordsLinked to original sources

Etomidate infusion and adrenocortical function. A study in elective surgery.

The adrenocortical response to a short tetracosactrin (Synacthen) test was studied in 11 patients receiving either etomidate infusion or thiopentone infusion used to maintain anaesthesia for abdominal hysterectomy. Pethidine was used as the narcotic component. The results showed that etomidate infusion (median 28.5 ug/kg/min) completely blocked the adrenocortical response to corticotropin stimulation for at least 24 h after surgery. No suppression was found in patients receiving thiopentone infusion. It is concluded that etomidate cannot be recommended for routine induction and maintenance of anaesthesia.

Adrenal Cortex↗

The amplitude of the c wave in the human ERG as a function of the luminous energy of the stimulus.

Variation of the stimulus intensity and duration over a wide range causes a change in amplitude of the c wave. If the energy of the applied stimulus is kept constant, however, stimuli of 0.05-4 s duration effected c waves that were nearly equal in amplitude. As patients consider shorter stimuli with higher intensities to be more comfortable in ERG recording, stimuli of a duration of 2-4 s seem most appropriate for clinical testing.

Adult↗

Visual evoked potentials as an aid in evaluating brain dysfunction following concussional injury: an animal model.

Visual evoked potentials were recorded sequentially, using permanent epidurally implanted electrodes, before and after accelerating the heads of rabbits. The amplitude of VEP, recorded after lesioning, was diminished and recovery time was prolonged depending on the amount of acceleration and the extent of brain lesions found later in histological examinations. VEP reflected damage to the brain more precisely than EEG or somatosensory evoked potentials, thus giving values for judging the extent of lesions in patients with brain injuries.

Animals↗