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Biomedical subjects

M Hafeez

Publications and source records attributed to M Hafeez.

8 recordsLinked to original sources
PubMed1991

Pathology and clinical features of gastro-intestinal lymphoma in Saudi Arabia.

The histopathology and clinical presentation of 19 cases of primary gastrointestinal lymphoma is described. Our patients are similar to others in the Middle East but have a lower incidence of diarrhoea and malabsorption. All revealed a widespread chronic inflammatory background. Four patients with primary gastric lymphoma had endoscopic biopsies from the duodenum; these biopsies were completely free from tumour but showed a moderate to severe diffuse lymphoplasmacytic infiltrate. Electron microscopy shows that tumour cells penetrate basement membranes and invade the epithelium which becomes thin and attenuated. Substances which inhibit lymphocyte tropism might be useful in preventing intestinal ulceration. The MALT concept has been found useful in classification of the tumours. Two patients with unusual mesenteric node histology are described and it is thought that the appearances may indicate a substantial capacity for differentiation in the group of tumours.

Adult↗
PubMed1989

Bioavailability, disposition kinetics and renal clearance of ampicillin following three routes of administration in sheep.

Bioavailability, disposition kinetics and renal clearance of ampicillin were investigated in 8 sheep following intravenous (i.v.), or intramuscular (i.m.) injection of 10 mg/kg or oral administration of 20 mg/kg dose. Peak of absorption was achieved in 26 +/- 9 min (mean +/- SD) after i.m. and 85 +/- 24 min after oral administration. The relative bioavailability of i.m. injected drug was 95 +/- 20 per cent compared to only 37 +/- 7 per cent following oral administration of double the dose. The disposition kinetics parameters of ampicillin were comparable in sheep with all three routes of drug administration. The renal clearance of ampicillin varied between 0.20 and 0.62 ml/min.kg while total body clearance was 50 to 64 ml/min.kg. The fractional urinary excretion of ampicillin in the first 8 hours after dosing was less than 1 per cent of the dose by all three routes.

Administration, Oral↗
PubMed1984

Case report: CT findings in lumbosacral agenesis.

This case describes a newborn paraplegic male with lumbosacral agenesis and related congenital anomalies, including bilateral hip dislocations, arthrogryposis, talipes equinovarus, as well as neurogenic bladder with urine incontinence. An extra-dural tumor, surgically excised and diagnosed as a lipoma, was identified on computed transaxial scans to be adjacent to an abruptly terminating dural sac. Caudal to the sac the scans demonstrated partial fatty replacement of muscle bundles and direct articulation of the iliac wings. A follow-up myelogram delineated the subarachnoid space, but could not distinguish the tumor from a deformed sac secondary to lumbar defects. Computed tomography is thus recommended as part of the general radiologic protocol for fully evaluating the spatial orientation and anomalies of this spinal defect.

Abnormalities, Multiple↗
PubMed1981

Studies on amphistomiasis in Andhra Pradesh (India) VI. Immunization of lambs and kids with gamma irradiated metacercariae of Cercariae indicae XXVI.

The life span and the pathogenicity of amphistomes developing from Cercariae indicae XXVI (Paramphistomum epicilitum) were considerably reduced when the metacercariae were gamma-irradiated at 2 krad or 3 krad. The higher irradiation dose resulted in the complete absence of the flukes in infected animals. Single vaccination of lambs and kids with 3000 metacercariae irradiated at 2 krad or 3 krad stimulated a significant degree of resistance against challenge with 5000 non-irradiated metacercariae. The resistance was more pronounced in the group vaccinated with metacercariae irradiated at 3 krad.

Animals↗