Biomedical subjects

M Hakakha

Publications and source records attributed to M Hakakha.

5 recordsLinked to original sources

PubMed1995

[Biomaterials and hernia surgery. Rationale for using them].

UNLABELLED: A study was made of the distinct biomaterials used in surgery and the requirements to be fulfilled and principles applied for their use in the repair of abdominal wall hernias. The biomaterials most frequently used in hernia surgery are: politetrafluorethylene (PTFE) sheet (Gore-Tex), the multifilament PTFE mesh (Teflon), the multifilament polypropylene mesh (Surgipro), the mono-filament polypropylene mesh (Marlex), the double filament polypropylene mesh (Prolene) and the multi-filament polyester mesh (Mersilene). Requirements for use in hernia surgery: the material must be inert, permanent and non-reabsorbable, resistant to infection, becomes rapidly fixed and incorporated into the host tissues, and not adhere to abdominal viscera. Principles for use: based on the overlapping of the mesh with the aponeurotic plane such that abdominal pressure aids fixation to this plane; contact with abdominal viscera must be avoided. CONCLUSIONS: based on the published experimental and clinical experience of the authors and other researchers, polypropylene is judged to be the most appropriate material for the repair of abdominal hernias.

Biocompatible Materials↗

PubMed1995

[Preliminary evaluation of composite materials for the repair of incisional hernias].

Recent investigations have shown that direct exposure of the intestines to currently available absorbable and nonabsorbable biomaterials can result in their adhesion to the bowel. This can then lead to bowel obstruction or migration of the mesh into the intestinal lumen and formation of intestinal fistula. It has been suggested by some authors that an absorbable covering of the peritoneal side of a nonabsorbable mesh would prevent adhesions and biomaterial related intestinal fistula formation. However, the effectiveness of such a combination has not been substantiated by recent experimental and clinical studies. This preliminary report examines the feasibility of combining porous and non-porous biomaterials for the creation of a composite that would incorporate with the abdominal wall without adhering to the intestines.

Animals↗

PubMed1995

Biomaterials for "tension-free" hernioplasties and principles of their applications.

Although decreasing, there exists an unjustified fear of mesh for the repair of inguinal and incisional hernias. This is due to the negative experience of the past when ideal biomaterials were not available. At the time of introduction of Marlex mesh by Francis Usher, three decades ago, ideal suture material for fixation of the mesh was not available and created undesirable complications. This compounded the fear of mesh for the repair of abdominal wall hernias. With the variety of prosthetic and suture materials available today, the importance of biomaterials in abdominal wall hernia surgery is increasingly appreciated. The purpose of this paper is to discuss some important requirements of ideal biomaterials and principles of their surgical application.

Animals↗

PubMed1994

Experimental evaluation of a new composite mesh with the selective property of incorporation to the abdominal wall without adhering to the intestines.

This preliminary study examined the possibility of preventing intestinal adhesions to biomaterials while preserving their incorporation with the abdominal wall. White New Zealand rabbits received intraperitoneal implants of different biomaterials for repair of defects created on the abdominal wall. The following biomaterials were used: polypropylene, polyester, expanded polytetraflueroethylene, polypropylene mesh/polypropylene sheeting (polypropylene mesh covered with polypropylene sheeting on the peritoneal side), polypropylene/silastic, polypropylene/polyglactin, polypropylene/polyglycolic acid, and polypropylene/fibrin. All biomaterials evaluated caused adhesions to the intestines except for polypropylene mesh/polypropylene sheeting and polypropylene mesh/silastic composites. Because adhesion of the intestine to the biomaterial is the first stage of biomaterial-related intestinal fistula, its prevention is logical for the elimination of this complication. Composites with the selective property of adhering to the abdominal wall, yet sparing the viscera, would facilitate thoracic and abdominal wall surgeries, as well as intraperitoneal laparoscopic hernioplasties.

Abdominal Muscles↗

PubMed1994

Biomaterials for abdominal wall hernia surgery and principles of their applications.

This article focuses special attention on the porosity, cellular permeability and molecular permeability of biomaterials and their effect on infection, host tissue incorporation and seroma formation when mesh is used for the repair of abdominal wall hernias. Furthermore, the general principles of the application of biomaterials, regardless of the technique used for their employment, is discussed.

Abdominal Muscles↗