The Fitz-Hugh-Curtis syndrome in a man revealed by ectopic appendicitis.
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Adult↗
Biomedical subjects
M Hamdan
Publications and source records attributed to M Hamdan.
[Intestinal ascariasis. A rare cause of obstruction of the small intestine].
Ascariasis is a benign and common disease in tropical areas. Due to its endemicity and high prevalence, serious abdominal complications requiring urgent and versatile surgical therapy do occur. An observation of intestinal obstruction by ascaris bundle, diagnosed during operation, is reported. The postoperative course was uneventful.
Adult↗
[Emphysematous cystitis. Apropos of a case].
Emphysematous cystitis is a rare complication of lower urinary tract infection, occurring almost exclusively in diabetic women. The prognosis, usually good, depends on early diagnosis and prompt treatment which consists of urinary drainage, antibiotic therapy and strict blood glucose control. The authors report a case of emphysematous cystitis diagnosed on laparotomy for acute abdomen. Death occurred despite treatment.
Aged↗
[Pseudotumoral inflammatory process of appendiceal origin. Conservative treatment by appendectomy].
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Adult↗
Comparison of muscle sympathetic responses to hemorrhage and lower body negative pressure in humans.
We compared changes in muscle sympathetic nerve activity (SNA) during graded lower body negative pressure (LBNP) and 450 ml of hemorrhage in nine healthy volunteers. During LBNP, central venous pressure (CVP) decreased from 6.1 +/- 0.4 to 4.5 +/- 0.5 (LBNP -5 mmHg), 3.4 +/- 0.6 (LBNP -10 mmHg), and 2.3 +/- 0.6 mmHg (LBNP -15 mmHg), and there were progressive increases in SNA at each level of LBNP. The slope relating percent change in SNA to change in CVP during LBNP (mean +/- SE) was 27 +/- 11%/mmHg. Hemorrhage of 450 ml at a mean rate of 71 +/- 5 ml/min decreased CVP from 6.1 +/- 0.5 to 3.7 +/- 0.5 mmHg and increased SNA by 47 +/- 11%. The increase in SNA during hemorrhage was not significantly different from the increase in SNA predicted by the slope relating percent change in SNA to change in CVP during LBNP. These data show that nonhypotensive hemorrhage causes sympathoexcitation and that sympathetic responses to LBNP and nonhypotensive hemorrhage are similar in humans.
Adult↗
Inhibitory effects of procainamide on sympathetic nerve activity in humans.
In experimental animals, procainamide causes hypotension and reductions in efferent vasoconstrictor sympathetic outflow that may result from ganglionic blockade or central nervous system sympathetic inhibition. To test the hypothesis that procainamide decreases sympathetic nerve activity (SNA) in humans, we recorded postganglionic SNA in seven normal subjects in the baseline state and during infusions of procainamide HCl at 50 mg/min (loading) and 8 mg/min (maintenance). At the end of the loading infusion, mean arterial pressure (MAP) had decreased from 88.5 +/- 2.4 (mean +/- SEM) to 81.5 +/- 3.2 mm Hg (p less than 0.05), central venous pressure from 6.7 +/- 0.7 to 5.4 +/- 0.9 mm Hg (p less than 0.05), forearm vascular resistance (FVR) from 28 +/- 4.8 to 22.3 +/- 5.1 resistance units (p less than 0.05), and SNA from 259 +/- 47 to 94 +/- 26 units/min (p less than 0.05). These changes persisted during the maintenance infusion. Increased levels of SNA, FVR, and MAP provoked by the cold pressor test were reduced significantly by intravenous procainamide. In eight other subjects, intravenous procainamide HCl (15 mg/kg at 50 mg/min) caused dose-dependent inhibition of SNA that reversed as blood concentrations fell during drug washout. To determine if procainamide causes direct vasodilation, in nine subjects, graded infusions were delivered into the brachial artery at doses that produced no systemic effect. Ipsilateral FVR tended to increase during local intra-arterial infusion of procainamide. These data show that intravenous procainamide causes hypotension, vasodilation, and sympathetic withdrawal. Vasodilation does not result from a direct vasorelaxant effect of the drug.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗
[Epididymitis in infants. Apropos of a case and review of the literature].
Epididymitis is a rare disease in infants, and its symptoms are the same as those of torsion of the spermatic cord or of its adnexa. Its diagnosis is often surgical, and should lead to suspecting possible associated urogenital abnormalities, requiring appropriate urological investigations.
Epididymitis↗
[Oncocytoma of the kidney. Apropos of a case and review of the literature].
Renal oncocytoma is an unusual benign tumor, occasionally suspected on preoperative clinicoradiological features. Its diagnosis is histopathological. We report such a case, in which gross appearance showed renal cell carcinoma signs, but oncocytoma was suspected prior to surgery, confirmed by histopathology including electron microscopy.
Adenoma↗
[Abdominal pregnancy. An autochtonous case with full-term living normal infant].
Abdominal pregnancy is a serious obstetrical dilemma for mother and baby. Exceptional in the western world, it's often unsuspected or lately diagnosed. We report an autochtonous case, discovered at operation, with an alive, normal and full-term baby, and dramatic hemorrhagic consequences, threatening the mother's life.
Blood Transfusion↗
The prevalence of enamel mottling on incisor teeth in optimal fluoride and low fluoride communities in England.
The prevalence of enamel mottling in optimal and low fluoride areas of the West Midlands was studied in March 1989 using the Al-Alousi index and the TF index. A total of 600 children aged 8-10 years, in three groups of 200 each, formed the study group. Significantly more mottling was found in the optimal fluoride area, according to both indices, although the TF index demonstrated the difference more clearly. Social class had no effect upon the prevalence of mottling in the optimal fluoride area.
Child↗
Baroreflex control of muscle sympathetic nerve activity in borderline hypertension.
Patients with borderline hypertension have exaggerated vascular responses to orthostatic stress produced by tilt or lower body negative pressure (LBNP). It has been suggested that 1) in the supine position, these patients have augmented activity of cardiopulmonary baroreceptors that exerts an increased restraint on sympathetic vasoconstrictor tone; 2) withdrawal of this augmented inhibitory baroreceptor activity during orthostatic stress elicits augmented reflex sympathetic vasoconstrictor outflow; and 3) augmented cardiopulmonary baroreceptor activity may be secondary to impaired arterial baroreflex mechanisms. To test these hypotheses, we recorded muscle sympathetic nerve activity from the peroneal nerve in seven borderline hypertensive subjects and seven age-, sex-, and weight-matched normotensive subjects during three levels of nonhypotensive LBNP and infusions of phenylephrine and nitroprusside. During LBNP, reductions of central venous pressure were similar in borderline hypertensive and normotensive subjects, and arterial pressure and heart rate values were unchanged. Increases of sympathetic nerve activity, however, were significantly greater in borderline hypertensive than in normotensive subjects at each level of LBNP, indicating an augmented gain of the cardiopulmonary baroreflex. To determine whether this augmentation is related to impairment of arterial baroreflexes, we measured changes of sympathetic nerve activity during increases and decreases of arterial pressure produced with infusions of intravenous phenylephrine and nitroprusside. Central venous pressure was held at control levels by LBNP during phenylephrine and saline infusion during nitroprusside. Changes of sympathetic nerve activity during alterations of arterial pressure were similar in borderline hypertensive and normotensive subjects. These data show that cardiopulmonary baroreflex control of SNA is augmented in borderline hypertensive subjects and that this augmentation does not result from an attenuation of the arterial baroreflex.
Blood Pressure↗
[Diffuse retroperitoneal lymphangioleiomatosis].
A case of diffuse retroperitoneal lymphangiomatosis manifested by oedema of the left lower limb is reported. Non-invasive exploratory methods revealed a retroperitoneal pseudo-tumoral image. At laparotomy, a retro- and subperitoneal infiltration was discovered, and histology showed benign smooth muscle proliferation developed from the muscular layer of lymph vessels. There is no known successful surgical procedure for this type of lesion, and none of the treatments tested (oophorectomy or hormonal therapy) has proved to be effective.
Adult↗
[Nutritional status, food consumption and food supply of studies in Saudi Aribia. I. Anthropometric data].
A field study about the nutritional status was made in school classes with boys 6 to 19 years old in different regions of Saudi-Arabia. It is reported about 341 pupils in regard to weight, height, skinfold-thickness, circumferences and other body-size measurements. In comparison with anthropometric measurements of comparable surveys in other countries, the Saudi-Arabian school boys were found to be smaller and leaner than boys from the USA, Europe, other Arabian countries and well-to-do Indian boys.
Adolescent↗
[Nutritional condition, food consumption and nutritional intake in students in Saudi Arabia. II. Food consumption and nutritional intake].
In field surveys in 13 schools in different regions of Saudi-Arabia, energy expenditure, food consumption, and nutrient intake were studied. Cereal products, especially bread, have the greatest significance in nutrition. Many students do not eat other foodstuffs regularly. A certain dependency of food consumption from the region was found in regard to the schools. The frequency of foodstuffs was generally low, but lowest in remote villages. In some age groups, the sufficient energy intake leaves much to be desired, 70 % do not reach recommended dietary allowances of animal protein and 100 % in fat. Intake of carbohydrates was too high, while intake of linoleic acid, minerals and vitamins is too low of nearly all test persons. To secure regularly a sufficient intake of essential nutrients, a school lunch program for the Saudi-Arabian boys is to be recommended.
Adolescent↗
Monitoring 2-D gel-induced modifications of proteins by MALDI-TOF mass spectrometry.
In addition to more than 200 endogenously produced post-translational modifications, a detailed analysis of 2-D gel-separated proteins must also consider other modifications that a protein can experience during various steps of its separation. This review describes the use of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry to investigate some of these modifications, which can originate during sample preparation and/or during the separation phase. The analyses described were mostly conducted at pH 9-9.5, and yielded reliable information on stable adduct formation that involved protein-bound amino acids and a number of gel components, including acrylamide derivatives, gel cross-linkers, and Immobiline chemicals. The -SH group of Cys was found to be the prime target of such adducts; however, longer reaction times revealed the involvement of the epsilon-NH2 of Lys. The same analysis revealed that the failure to achieve full reduction/alkylation prior to any electrophoretic step could result in protein-protein interaction, which could lead to a number of spurious spots in the final 2-D map. The implications of these modifications on the MS analysis in particular and on proteome research in general are discussed.
Alkylation↗
Toward the rational development of peptidomimetic analogs of the C-terminal endothelin hexapeptide: development of a theoretical model.
In an early report on the structure-activity relationship of endothelin (ET) peptides, it was reported that the C-terminal hexapeptide ET(16-21), His-Leu-Asp-Ile-Ile-Trp, is the minimum ET fragment which maintains biological activity in some, but not all the tissues responding to ETs. Subsequently, other authors described a series of analogs of this peptide, in which the His 16 residue was replaced by non-natural amino acids, characterized by bulky aromatic side chains. Among them, two well-characterized non-selective ETA/ETB antagonists were PD 142893 and PD 145065; interest in these potent ET antagonists was, however, reduced by their peptidic structure which was likely to lead to undesirable properties such as poor bioavailability and short duration of action. On the basis of these premises, our previous studies led to the development of a peptidomimetic ligand of ET receptors (compound 3), based on the replacement of the His 16 residue of ET(16-21) with an (E)-N-(benzyloxy)iminoacyl moiety; compound 3 proved to possess a certain affinity for ET receptors, albeit lower than that shown by PD 142893 and PD 145065. We report here on ETA/ETB binding affinity of compounds 4-12, designed as a new series of ET(16-21) analogs. Compounds 4 and 5 were practically devoid of any affinity; derivatives 6-12 exhibited appreciable affinity indices for ETB receptors higher than that shown by 3, even if still lower than that obtained for PD 145065. This paper also describes the development of a pharmacophoric model able to explain the ET receptor binding properties of our hexapeptide analogs compared with those of PD 142893 and PD 145065 and IRL2500, recently reported as a potent ETB selective endothelin antagonist.
Amino Acid Sequence↗
Binding of human GM-CSF to synthetic peptides of the alpha subunit of its receptor.
We have synthesized a series of peptides corresponding to portions of the extracellular domain of human granulocyte-macrophage colony stimulating factor receptor alpha subunit (hGM-CSFR alpha). The sequences were chosen according to the homology between hGM-CSFR alpha and the growth hormone receptor (GHR) and correspond to the regions reported to form the binding site of the latter receptor. The peptides were examined for their binding activity to hGM-CSF by affinity chromatography on resin-immobilized hGM-CSF and by a solid phase binding assay. For peptides endowed with hGM-CSF binding activity were identified and the postulated homology between the binding sites of hGM-CSFR alpha GHR was confirmed.
Amino Acid Sequence↗
[Metastatic jejunal perforation of cancer of the larynx].
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Aged↗