Biomedical subjects
Publications and source records attributed to M Hamdani.
We report a case of Goldenhar syndrom in thirty eight old woman who has been refered to us for peribulbar choristoma. The authors discuss the different ophthalmological, otolaryngological and general manifestation of this syndrom and the therapeutic modalities of the ocular anomalies.
An investigation was carried out to determine whether isooctane and ethanol behave like sunflower oil as fatty simulants for overall and for specific migration from PVC containing aromatic plasticizers (bis-2-ethylhexyl phthalate and tris-2-ethylhexyl trimellitate). In these films, the partition coefficients of migrants between simulant and polymer play a major role. The affinities of isooctane and of sunflower oil to all migrants were similar and isooctane can be considered as an alternative fatty simulant for plastized PVC. In contrast ethanol displays a different selectivity, and is not an adequate fatty simulant. Guidelines for the selection of solvents to be used as fatty simulants for migration testing are discussed. The scope of spectroscopic methods (FTIR and 1H-NMR) to monitor migration of aromatic plasticizers is presented.
A general strategy is presented, aiming to provide plastics manufacturers, food industries and enforcement laboratories with quick methods to check whether migration from materials for food contact will be acceptable during the time of use. The strategy involves several steps, with increasing time demand and cost. Monitoring extraction kinetics allows both the optimization of the extraction time, and the selection of conditions where extraction is more severe than migration. The influence of the extracting solvent is discussed. It may give rise to specific non-extraction of some migrants, which may change the conclusions when the solvent is used in replacement of a fatty food simulant. Factors ruling this effect at a given temperature are identified: the affinity to the solvent with the migrant (selectivity), its ability to reach molecules entangled in the polymeric network (accessibility) and its interaction with the polymer (penetration). The kinetic parameters of the penetration of olive oil into polypropylene have been determined by the determination of profiles of concentration.
BACKGROUND AND OBJECTIVES: Clonidine, an alpha-2-adrenoreceptor agonist, has been shown to decrease intraocular pressure (IOP) and to have some analgesic and sedative effects when it is used in premedication for ophthalmic surgery. This study was designed to investigate the efficacy of lidocaine-clonidine retrobulbar block for cataract surgery with respect to its effect on IOP, analgesic action, and sedative effects. METHODS: Sixty elderly patients (ASA status I and II) were allocated randomly to receive in a prospective double-blind manner retrobulbar block for cataract surgery. Group I (n = 30) received 3-4 mL of 2% lidocaine with 1 mL saline, while group 2 (n = 30), received 3-4 mL of 2% lidocaine with clonidine 2 micrograms/kg. RESULTS: A large decrease in intraocular pressure from 13.5 +/- 4.6 to 7.7 +/- 3.7 mm Hg (P < .01) and a small but significant reduction of both systolic and diastolic blood pressure were observed 20 minutes alter the retrobulbar block in patients receiving clonidine, while no changes occurred in the control group. The median duration of analgesia and akinesia was greater in the lidocaine-clonidine group (241 +/- 88 minutes and 80 +/- 20 minutes, respectively) as compared with the lidocaine group (128 +/- 24 minutes and 70 +/- 20 minutes, respectively) (P < .01, P < .05). Sedation scores were greater in group 2 from the 10-minute point (P < .01). CONCLUSIONS: Addition of clonidine to lidocaine for retrobulbar block causes a decrease in intraocular pressure, a sedative effect, and an increased duration of analgesia and akinesia, with relatively stable hemodynamic parameters.