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Biomedical subjects

M Hamilton

Publications and source records attributed to M Hamilton.

At least 37 records · Page 2Linked to original sources
PubMed1979

Effects of carbon monoxide on operant behavior of laboratory rats and baboons.

Carbon monoxide (CO) was evaluated for its effects on the operant behavior of laboratory rats and juvenile baboons. For the rat studies the procedures included a 2-min variable interval (2-min VI) or fixed interval (2-min FI) schedule of reinforcement, a 60:1 fixed ratio (FR) schedule and a multiple fixed ratio, fixed interval (FR:FI) schedule. Carbon monoxide concentrations of 50-200 ppm for 2-hr exposure periods produced minimal effects on VI rates. Response rates were increased for all animals somewhere in the concentration range of 25-200 ppm. Response rates were depressed at 500 ppm CO. Behavioral effects at 50 ppm CO were not correlated with blood CO levels. Data averaged for grops of three animals show FI rate increased slightly above controls at 50 and 100 ppm CO and decreased at 200 ppm. FR rate increased at 50 ppm and decreased at 100 and 200 ppm. For the baboon studies, a delayed match-to-sample discrimination task was used. The effects of CO (6 hr per day over a 5-day period) on the discrimination task was limited to an occasional mistake by an animal. CO did produce a slowing of the animals' response times as well as an increase of extra responses during the delay intervals. The changes in extra responses were dose related.

Animals↗
PubMed1978

Total exchangeable potassium in response to amiloride.

The use of amiloride is described in twenty-four hypertensive patients who became hypokalaemic as a result of thiazide diuretic therapy in spite of oral potassium supplments. Amiloride caused a significant rise in exchangeable potassium, exchangeable potassium/kg body weight, and plasma potassium, together with a significant fall in plasma total carbon dioxide, body weight, systolic and diastolic blood pressures. These results suggest that amiloride has a useful role in this type of patient.

Amiloride↗
PubMed1978

Paranoid states.

Paranoid states is a term that covers a number of different disorders in which persecutory and grandiose ideas and delusions constitute a significant part of the symptoms. The most important are those conditions that are now generally accepted as being members of the group of schizophrenias. These symptoms become more important in conditions of social isolation and sensory deprivation. They appear in some organic cerebral conditions and may colour any breakdown that develops in some types of personality.

Hearing Disorders↗
PubMed1977

A simple discriminant function for hepatic disease.

Tests of hepatic function do not correlate highly and this, together with their skew distribution, makes the information provided by them difficult to interpret. By means of an appropriate transformation it is possible to normalise their distributions so that the information from them can be combined in the form of a discriminant function which is not only easy to interpret but gives an index of severity of disease which is more reliable than any one single test. In this study nine tests were examined, and after normalisation it was found that only four tests were required to present almost all the information available in the nine. A formula is given for calculating the index in T-score form, which is particularly easy to interpret. A discriminant function of the type described retains the maximum information with the minimum number of biochemical tests. It therefore contributes to the solution of a problem which is causing increasing concern--the exponential increase in the number of investigations which the hospital services will soon find it impossible to bear.

Analysis of Variance↗
PubMed1976

The Leeds scales for the self-assessment of anxiety and depression.

Self-rating scales are finding an increasing use in psychiatric work. Not only are they widely used in research, but they provide the clinician with a score indicating the patient's psychiatric state at any one time, and these scores if repeated throughout the duration of treatment may be considered to provide a continuing measure of the severity of the illness, as does a temperature chart in a febrile illness. Most scales could be improved by item analysis, and in this study the Wakefield Self-Assessment of Depression Inventory, with added items, was subjected to statistical analysis. It was found that valid scales could be constructed for the measurement of anxiety and of depression in general psychiatric disorders, as well as scales for the measurement of the severity of endogenous (primary) depression and of anxiety states. In addition, the derivation of a 'diagnostic' score was confirmed in a cross-validation study and may be found of use both in research and in clinical practice.

Adjustment Disorders↗
PubMed1976

Compressed air code.

Explore the source record for details and available documents.

Decompression Sickness↗
PubMed1976

Chemical safety.

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Chemical Industry↗