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M Hannes

Publications and source records attributed to M Hannes.

5 recordsLinked to original sources
PubMed1999

[In vitro fertilization at the Erasme Hospital: 10 years and 1000 pregnancies later...].

This contribution summarize ten years of in vitro fertilization of clinical work. Activity growth, improvements of results (mean fertilization rate increased from 45% to 58%, fertilization failure dropped from 18% to 7%, pregnancy chances gains 9% to reach 44% per trial) and new treatments possibilities (severe male infertility) thanks to the ICSI technic were the major characteristics of this last ten years. The original anonymous oocyte donation program with donors permutation initiated as soon as 1990 has imposed itself due to it's exceptional efficiency with a pregnancy rate of 95% per oocyte pick up on a population of 46 donors and 145 recipient cycles. Thanks to the large population studied (4028 cycles, 1071 pregnancies), the tendencies in human fecundity (impact of age) and the risks linked to multiples pregnancies could be highlighted, stressing the importance of future developments presented in the other contributions following this general presentation of results.

Adult↗
PubMed1999

[Evolution of ovarian stimulation in in vitro fertilization].

This paper reviews the different treatments of ovarian stimulation for in vitro fertilization (IVF). It emphasizes the recent development of new molecules, including recombinant gonadotrophins and GnRH antagonists. Because of their higher purity, recombinant gonadotrophins are theoretically less immunogenic than the urinary forms. Their preparation mode ensures a better batch to batch consistency. Their clinical use in IVF seems to be associated with a higher number of developing follicules and retrieved oocytes, but pregnancy rates are comparable to those obtained after ovarian stimulation with urinary gonadotrophins. The GnRH antagonists induce a direct inhibition of the pituitary gonadotrophin secretion. In association with an ovarian stimulation with gonadotrophins, they efficiently prevent premature LH surges when administered during the end of the follicular phase. The GnRH antagonists are still in clinical evaluation phase and the optimal protocol and dose still to be defined. They should become available in the coming year. The risks related to the controlled hyperstimulation together with the reduction of the number of transferred embryos has recently led "soft stimulation" to a reevaluation of the stimulation protocols towards a simplified procedure. However, the validity of this attitude could be in opposition with the wish to limit the number of transferred embryos since embryo quality seems to be directly related to the total number of embryos.

Clomiphene↗
PubMed1992

[Recurrent spontaneous miscarriage].

Spontaneous recurrent miscarriages still represent a poorly defined entity. It is commonly accepted that they include early (1st trimester) spontaneous abortion thus excluding those related to well documented chromosomal, anatomical, hormonal or autoimmune causes such as SLE or anticardiolipin syndrome. There is also a general consensus based upon historical series to require at least three consecutive miscarriages. In a series of 58 consecutive couples with recurrent miscarriages studied at the clinics of immunology of pregnancy, a careful investigation could demonstrate the high incidence of anatomical abnormalities detected by hysterosalpingography and consisting mostly of uterus bicornis or uterus septus. This finding emphasises the importance of this examination. Some of these cases required surgical or endoscopic therapy. Only one patient displayed chromosome abnormalities excluding her from the definition of spontaneous recurrent miscarriage. The other patients were treated either with paternal leucocytes or gammaglobulins.

Abortion, Habitual↗