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Biomedical subjects

M Hanson

Publications and source records attributed to M Hanson.

At least 55 records · Page 3Linked to original sources

Assignment of the mouse and cow CXC chemokine genes.

Gene specific PCR primers were constructed for five mouse and three bovine CXC chemokine genes. The mouse genes were assigned using SSCP analyses of the Jackson BSS backcross panel to two groups on chromosome 5. One group containing Gro1 and Mip2 cosegregated with reference markers Alb1 and Btc, and was positioned 2.2 cM proximal to a group comprising Ifi10, Mig, and Scyb5. The bovine genes IL8, GRO1, and GRO3, mapped using bovine x hamster somatic cell hybrids, were all found to be located on chromosome 6. The locations of these genes in these two animal species are consistent with the positions in humans (4q13-->q21), and previous syntenic relationships among these three mammals.

Animals↗

The integration of child psychiatry into a psychiatry clerkship OSCE.

OBJECTIVE: To integrate child psychiatry into a psychiatry clerkship OBJECTIVE Structured Clinical Examination (OSCE). METHOD: Child psychiatry OSCE stations were designed to evaluate clerk' skills in the identification of 4 common conditions. Child psychiatrists wrote case scenarios and checklists and supported standardized patient (SP) training for the stations. A bank of 4 child psychiatry OSCE stations is now available for use in the psychiatry OSCE. Child psychiatry faculty have been trained as examiners for ongoing administration of his OSCE. RESULTS: This bank of child psychiatry OSCE stations has examined 402 clerks. Mean student scores for content were 68% to 86% and for process were 69% to 76%. Station reliability and examiner feedback were acceptable. CONCLUSIONS: Child psychiatry has been successfully integrated into a psychiatry clerkship OSCE. Although the commitment in terms of monetary and faculty costs has been considerable, the accompanying educational benefits of such integration warranted this expense.

Child↗

Four-hour voiding observation in young boys with posterior urethral valves.

PURPOSE: We evaluated 4-hour voiding observation as a method of basic assessment of bladder dysfunction in young boys with posterior urethral valves. MATERIALS AND METHODS: Voiding pattern, including number of voids, voided and residual urine volume, and bladder capacity, was determined noninvasively in 24 boys younger than 4 years with posterior urethral valves and compared to that of healthy age matched controls. Results were then compared to those of standard cystometry. RESULTS: The number of voids was higher, voided volume was smaller and residual urine volume was higher in the posterior urethral valve group. There was no difference in voiding pattern before and after removal of the anatomical obstruction. Voided and residual urine volume, and bladder capacity were higher on standard cystometry than on voiding observation. CONCLUSIONS: Four-hour voiding observation is an easy noninvasive method that focuses on emptying difficulties and clearly detects differences in voiding patterns between boys with posterior urethral valves and healthy, nontoilet trained children. We recommend the method as a complement to standard cystometry for the diagnosis and followup of bladder dysfunction in young boys with posterior urethral valves to identify the need for treatment.

Child, Preschool↗

Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.

The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs. The chromosome contains 853 genes encoding a basic set of proteins for DNA replication, transcription, translation, solute transport and energy metabolism, but, like Mycoplasma genitalium, it contains no genes for cellular biosynthetic reactions. Because B. burgdorferi and M. genitalium are distantly related eubacteria, we suggest that their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors. Of 430 genes on 11 plasmids, most have no known biological function; 39% of plasmid genes are paralogues that form 47 gene families. The biological significance of the multiple plasmid-encoded genes is not clear, although they may be involved in antigenic variation or immune evasion.

Biological Transport↗

Stress management and exercise training in cardiac patients with myocardial ischemia. Effects on prognosis and evaluation of mechanisms.

BACKGROUND: Previous studies have demonstrated that myocardial ischemia can be elicited by mental stress in the laboratory and during daily life and that ischemia induced by mental stress is associated with an increased risk for future cardiac events in patients with coronary artery disease. OBJECTIVES: To examine the extent to which ischemia induced by mental stress can be modified by exercise stress management, and to evaluate the impact of these interventions on clinical outcomes. METHODS: One hundred seven patients with coronary artery disease and ischemia documented during mental stress testing or ambulatory electrocardiographic monitoring were randomly assigned to a 4-month program of exercise or stress management training. Patients living at a distance from the facility formed a nonrandom, usual care comparison group. Myocardial ischemia was reassessed following treatment, and patients were contacted annually for as long as 5 years to document cardiac events, including death, nonfatal myocardial infarction, and cardiac revascularization procedures. RESULTS: Twenty-two patients (21%) experienced at least 1 cardiac event during a mean (+/- SD) follow-up period of 38 +/- 17 months. Stress management was associated with a relative risk of 0.26 compared with controls. The relative risk for the exercise group also was lower than that of controls, but the effect did not reach statistical significance. Stress management also was associated with reduced ischemia induced by mental stress and ambulatory ischemia. CONCLUSION: These data suggest that behavioral interventions offer additional benefit over and above usual medical care in cardiac patients with evidence of myocardial ischemia.

Adult↗

Managers' attitudes towards mechanical aids.

This article reports a study of the attitudes of NHS management and financial personnel to issues of moving and handling, in particular the use of mechanical aids. The study highlights some confusions about the responsibilities and roles of different personnel, and the authors make some recommendations to clarify these.

Attitude of Health Personnel↗

An objective structured clinical examination for evaluating psychiatric clinical clerks.

PURPOSE: To assess the feasibility, reliability, and validity of an objective structured clinical examination (OSCE) for psychiatric clinical clerks. METHOD: In 1995 two parallel forms of a ten-station OSCE (eight clinical stations, two writing stations) were developed at the University of Toronto Faculty of Medicine Each 12-minute performance-based clinical station was assessed by a faculty psychiatrist using both a checklist for each student's performance content and a global-rating scale of the performance process. The students' clinical-station scores were calculated as the average of their content and process scores (expressed as percentages). Examiners also recorded an overall judgment of each students' performance (pass, borderline, or fail) and wrote [in collaboration with the standardized patient (SP) at that station] comments on each student's performance. There were two criteria for a passing grade: a total mark of 60% or higher across all ten stations and a "pass" or "borderline" mark in at least five of the eight clinical stations. Each OSCE form was administered three times. RESULTS: The first form was used to examine 94 clerks, the second form to examine 98 clerks. The students' mean scores for the two forms were 70.47% (SD, 6.33%) and 67.66% (SD, 7.05%), respectively. In addition to the standard evaluation information collected on the students, several critical incidents occurred (e.g., a student's loss of control of emotions) that may identify potential problems in professional conduct. The direct cost for one administration of the examination was approximately Can$3,300: the largest portion of this was for the SPs' time spent in training and performing their roles. CONCLUSION: Preliminary evidence suggests that a psychiatry OSCE is feasible for assessing complex psychiatric skills. However, careful attention must be paid to SP training, examination monitoring, detection of critical incidents, and provision of feedback to students, faculty, and SPs. The university's previous system of oral examinations required approximately 600 faculty hours per year. The OSCE requires approximately 450 faculty hours, and the 150 hours saved almost cover the Can$20,000 that the examination costs each year. In all, the OSCE is an evaluation system that has demonstrable reliability and is more enjoyable for both the faculty and the students.

Clinical Clerkship↗

Work-related injuries in trade apprentices.

This study attempted to identify and describe all work-related injuries in a cohort of trade apprentices at the Canberra Institute of Technology over an approximate one-year period. In 997 persons followed for a total of 198,456 days of exposure there were 771 injuries of which 191 were classed as serious (defined as at least one day off work and/or received sutures and/or required hospital treatment). The most common circumstance of injury was a cut to the fingers or hand while using a sharp-edged, non-powered hand tool. At least 52 persons required hospital treatment and another 51 required suturing. Overall rates of injury were 222 (95 per cent confidence interval (CI) = 193 to 256) injuries per 1000 full time equivalents (FTEs) and 169 (95% CI = 147 to 193) injured persons per 1000 persons. Injury rates adjusted for stage (year of course) were significantly different between schools and were highest in the construction and engineering trades groups (chi 2(5) = 57.30, P < 0.001). There was a statistically significant trend of higher risk of injury with later stage after adjustment for school (chi 2(2) = 6.34, P = 0.042). This study has shown that trade apprentices are at high risk of significant work-related injury and provides important insights into the characteristics of work-related injuries in trade apprentices. These have significant implications for the safety expectations apprentices may bring to the workplace and for the appropriate targeting of occupational health and safety training of apprentices in the trade occupations.

Accidents, Occupational↗

An evaluation of mechanical aids used within the NHS.

This paper describes Phase III of the study of mechanical aids used within the NHS, the aim of which was to evaluate the acceptability and effectiveness of mechanical aids within the service. Phases I and II of the study consisted of interviewing nurses and clients concerning their attitudes towards mechanical aids and observing nurses in the clinical area using mechanical aids. Phase III consisted of an experiment being undertaken to compare the usability of a number of mechanical aids for controlled task in a laboratory environment. The aim of this was to compare a number of different mechanical aids currently available, for perceived safety, comfort, ease of use and manoeuvrability in ward simulated conditions.

Clinical Nursing Research↗

A study into clients' attitudes towards mechanical aids.

In the second article of three (the first appeared in last week's issue), the authors describe Phase II of the study "An Evaluation of Mechanical Aids used within the NHS', the aim of which was to evaluate the acceptability and effectiveness of mechanical aids. In this article clients' attitudes toward mechanical aid use is considered. This is supplemented by data obtained through observing nurses and clients using mechanical aids in the clinical area. It was found that, although mechanical aids were considered desirable and safe by most patients and their operation involved only moderate postural discomfort to the nurses operating them, the nurses still offered client discomfort or fear as a reason for not using the aids. The authors offer some recommendations to encourage increased use of mechanical aids in appropriate client care situations. The final article, describing Phase III of the study, will appear in next week's issue.

Attitude of Health Personnel↗

A study of nurses' attitudes towards mechanical aids.

Publication of the Manual Handling Operations Regulations (HSE 1992) focused attention on the use of mechanical aids for the purposes of moving and handling. However, nurses' reluctance to use this equipment has been widely documented. The reasons for this are complex and the aim of this study was to examine in depth the effectiveness and acceptability of mechanical aids to nurses and clients. This article reports on the part of the study which surveyed nurses' attitudes towards this equipment. The data were obtained by means of a semi-structured interview schedule. One hundred and eighty five nurses from a selection of specialties were interviewed. Common problems identified by the researchers were lack of proper training in mechanical aid use, mechanical aids and slings being unavailable or inaccessible, arbitrary use of mechanical aids and spatial constraints to mechanical aid use. Recommendations are made which aim to address the issues raised. Phases II and III of the study will appear in the next two issues.

Attitude of Health Personnel↗

Reliability of the Weak Opiate Withdrawal Scale for inter-city opiate users.

The reliability (Kuder-Richardson 20) of the 84-item Weak Opiate Withdrawal Scale was estimated for a sample of 70 inner-city men who used opiates and had passed through the acute withdrawal stage. Analysis suggested modification of the scale to exclude negatively worded as well as cognitively sophisticated items which elicit unreliable and paradoxical responses from this population.

Adult↗

Four-hour voiding observation in healthy infants.

PURPOSE: We present the 4-hour voiding observation as a method for basic assessment of bladder function in infants and nontoilet trained children. MATERIALS AND METHODS: Voiding pattern, including number of voidings, voided volume, bladder capacity and residual urine for 4 hours, was determined noninvasively in 43 healthy infants. RESULTS: The infants voided an average of 1 time per hour but with great variability. Bladder capacity increased with age according to the formula, 38 + 2.5 x age (months). Mean residual urine plus or minus standard deviation was 4.6 +/- 3.0 ml. In all infants residual volume was less than 5 ml. at least once during observation. CONCLUSIONS: The 4-hour voiding observation is an easy noninvasive method of characterizing the voiding pattern, focusing especially on emptying difficulties, in infants and nontoilet trained children.

Female↗

Should we do another test? Decision making in blood banking.

A decision model was developed to evaluate the costs and benefits of further reducing the risk of transfusion-transmitted disease. The model addresses recipient risk factors as well as operational considerations. Application of the model to prior risk reduction decisions documents its validity as a decision-making tool. Adoption of such a standardized decision-making approach would ensure recipient safety while controlling the costs of providing blood for transfusion.

Acquired Immunodeficiency Syndrome↗

Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Association and hemodynamic features.

BACKGROUND: The purpose of this study was to determine the correspondence of mental stress-induced ischemia in the laboratory with ambulatory ischemia and to assess the relationship between hemodynamic responses to mental stress and the occurrence of ischemia. Although exercise testing is usually used to elicit myocardial ischemia, ischemia during daily life usually occurs at relatively low heart rates and in the absence of strenuous physical exercise. Mental stress has been shown to trigger ischemic events in the laboratory at lower heart rates but at blood pressures comparable to exercise. We therefore compared the extent to which mental stress and exercise testing identify patients who develop ischemia out of hospital. METHODS AND RESULTS: One hundred thirty-two patients with documented coronary disease and recent evidence of exercise-induced myocardial ischemia underwent 48-hour ambulatory monitoring and radionuclide ventriculography during exercise and mental stress testing. Patients who displayed mental stress-induced ischemia in the laboratory were more likely to exhibit ischemia during daily life (P < .021). Furthermore, patients who exhibited ischemia during ambulatory monitoring displayed larger diastolic blood pressure (P < .006), heart rate (P < .039), and rate-pressure product responses (P < .018) during mental stress. CONCLUSIONS: Among patients with prior positive exercise stress tests, mental stress-induced ischemia, defined by new wall motion abnormalities, predicts daily ischemia independent of exercise-induced ischemia. Exaggerated hemodynamic responses during mental stress testing also identify individuals who are more likely to exhibit myocardial ischemia during daily life and mental stress.

Activities of Daily Living↗