Biomedical subjects

M Harju

Publications and source records attributed to M Harju.

At least 19 recordsLinked to original sources

PubMed1996

Postpartum recovery after severe pre-eclampsia and HELLP-syndrome.

Postpartum recovery was examined in 100 pregnancies complicated by severe pre-eclampsia, and in 15 pregnancies in which HELLP-syndrome as present. Albuminuria disappeared and diastolic blood pressure returned to normal (< 90 mmHg) in half of the cases within one week postpartum. Postpartum recovery in the cases with HELLP-syndrome did not differ from that seen in the pre-eclamptic patients. Thrombocytopenia showed spontaneous resolution within three days after delivery. In stepwise discriminant analysis, the incidence of IUGR predicted a slow postpartum recovery, but this did not apply to other factors. Such as diastolic blood pressure before delivery, duration of subjective symptoms, duration of pregnancy or severity of albuminuria. Elevated diastolic pressure and/or albuminuria were diagnosed two months postpartum in one third of the patients. If the development of eclampsia is prevented by correctly timing the induction of delivery, relatively good short-term postpartum recovery is probable after severe pre-eclampsia and HELLP-syndrome.

Adult↗

PubMed1996

Optic disc topography before and after trabeculectomy in advanced glaucoma.

BACKGROUND AND OBJECTIVE: To analyze changes in the optic disc topography after filtration surgery. PATIENTS AND METHODS: Laser scanning tomography was performed in 10 eyes of 9 patients (mean age 65.6 +/- 8.1 years; age range 55 to 75 years) after a mean follow-up of 3.7 months, and in 8 eyes of 7 patients (mean age 63.1 +/- 7.6 years; age range 55 to 75 years) after a mean follow-up of 13.1 months. RESULTS: Preoperatively, the mean intraocular pressure (IOP) was 24.4 +/- 6.9 mm Hg with maximal medication. Postoperatively at 3.7 months it was 11.0 +/- 2.2 mm Hg, and at l2.1 months it was l3.6 +/- 2.8 mm Hg. An initial reduction in IOP of more than 30 percent at 3.7 months was achieved without medication in all but 1 eye. After 12.1 months, an IOP reduction of more than 30 percent was achieved in 6 of 8 eyes (1 with medication), while 2 eyes had IOP reductions of less than 15 percent (< or = 3 mm Hg) despite medication. In the 6 eyes, the optic disc cup volume showed a decrease of more than 30 percent, while the 2 eyes without marked IOP reductions had slight increases in cup volume. Of the 2 eyes without marked decreases in cup size, 1 had normal-tension glaucoma and 1 experienced an increase in IOP of more than 25 mm Hg during the first postoperative week. CONCLUSION: The postoperative IOP should be kept low enough to permit reversal of optic disc changes.

Aged↗

PubMed1994

A randomized, prospective study on the use of sodium hyaluronate (Healon) in trabeculectomy.

The effect of injecting sodium hyaluronate (Healon) before fistulization in trabeculectomy was investigated in a prospective, randomized study of 107 consecutive eyes. Fifty-two eyes were operated on with the viscoelastic and 55 without. An early postoperative intraocular pressure (IOP) peak of 21 mm Hg or more occurred in 27% of the study eyes versus 17% of the control eyes, an insignificant difference. The mean peak IOPs of the study and the control eyes did not differ significantly (29.8 +/- 9.0 mm Hg versus 32.7 +/- 10.2 mm Hg), nor did the mean IOPs and the need for glaucoma medications 1 month after surgery. Shallow/flat anterior chamber and choroidal detachment were equally frequent in both groups, but hyphema occurred significantly more often in the study group (40%) than in the control group (18%).

Aged↗

PubMed1992

Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task.

The present study investigated the effects of dexmedetomidine (an alpha-2 adrenoceptor agonist), atipamezole (an alpha-2 adrenoceptor antagonist) and tacrine (an inhibitor of acetylcholinesterase) on the performance of adult and aged rats in a delayed non-matching to position task assessing spatial short-term memory. Most of the aged rats were impaired in the pretraining phases and in the acquisition of the non-delayed version of the task. After a substantial training period of the delayed version of the task, both adult and aged rats reached their asymptotic level of performance. Both adult and aged rats showed a decline in the percent correct responses at the longest delays in this task, and a delay independent decrease in the percent correct responses across the delays (0-30 s) was found in the group of aged rats (25-month-old) as compared to the adults (10-month-old). Dexmedetomidine (0.3, 1.0 or 3.0 micrograms/kg), atipamezole (0.03, 0.3 or 3.0 mg/kg) and tacrine (1.0 or 3.0 mg/kg) did not increase the percent correct responses in adult or aged rats. The highest doses of dexmedetomidine and tacrine decreased behavioural activity of rats during this short-term memory testing. Atipamezole (0.03 mg/kg) increased behavioural activity of rats. The results suggest that acute, systemic administrations of alpha-2 drugs or an anticholinesterase do not improve short-term memory in rats.

Adrenergic alpha-2 Receptor Agonists↗

PubMed1989

Occlusal anomalies in 45,X/46,XX- and 46,Xi(Xq)-women (Turner syndrome).

A total of 20 individuals with X-chromosome aberrations, 14 45,X/46,XX-women and six 46,Xi(Xq)-women, were examined for occlusal anomalies. The controls were first-degree woman relatives and population women. The results showed that the most common type of malocclusion in both study groups was lateral cross bite. Also distal molar occlusion, increased maxillary overjet and in 45,X/46,XX-women open bite was found. 45,X/46,XX-women's occlusion seems to be more affected than that of 46,Xi(Xq)-women. Compared to 45,X-women, the present study groups show milder expression of malocclusion. One might speculate that enamel genes of the X-chromosome are involved in occlusal development.

Adult↗

PubMed1986